National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

375 total trials 276 currently recruiting 93 completed

Trial Pipeline

RECRUITING

Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study

NCT06730113

RECRUITING Phase 2

VIR-2218 and Peginterferon Alfa-2a for Chronic Hepatitis B

NCT06092333

RECRUITING Phase 2

Desmopressin Stimulation Test Performance in ACTH-Dependent Cushing Syndrome

NCT06635629

RECRUITING NA

Pilot Study of Isocaloric Time Restricted Eating on Ketone Metabolism and Immunoregulation

NCT06169137

RECRUITING NA

Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change

NCT06325722

RECRUITING NA

Variability In Mixed Meal Tests: Fixed Versus Adjusted to Energy Needs Caloric Dose

NCT06223555

RECRUITING NA

Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate

NCT06044935

RECRUITING

Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD)

NCT05996536

RECRUITING Phase 2

Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States

NCT05832229

RECRUITING NA

The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure

NCT05545306

RECRUITING

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach

NCT04685200

RECRUITING Phase 2

Study of Growth Hormone Inhibition Using Pegvisomant in Severe Insulin Resistance

NCT05470504

RECRUITING

A Natural History Study of Metabolic Sizing in Health and Disease

NCT05398783

RECRUITING

Natural History of Pregnancy and Pregnancy Outcomes in Metreleptin-Treated vs Untreated Subjects With Lipodystrophy

NCT05419037

RECRUITING

Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment

NCT05213598

RECRUITING

Early Tracking of Childhood Health Determinants (ETCHED) Study

NCT03481829

RECRUITING Phase 1

Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake

NCT04799301

RECRUITING Phase 2

TReatment for ImmUne Mediated PathopHysiology

NCT04862221

RECRUITING

Evaluation of Patients With Gastrointestinal Disease

NCT05041374

RECRUITING

Natural History Study of Parathyroid Disorders

NCT04969926

RECRUITING Phase 2

The Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid Cancer

NCT04927416

RECRUITING Phase 2

The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer

NCT03841617

RECRUITING Phase 2

Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)

NCT03884075

RECRUITING

Study of Endocrine-Related Conditions and Physiology

NCT03867448

RECRUITING

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

NCT03374215

RECRUITING Phase 1

The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta3-Adrenergic Receptor Agonists

NCT03049462

RECRUITING

Evaluation of Adults With Endocrine and Metabolic-Related Conditions

NCT02830308

RECRUITING

Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and Its Role in Metabolism

NCT02692885

RECRUITING

Natural History of Noncirrhotic Portal Hypertension

NCT02417740

RECRUITING Phase 2

Prospective Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Ectopic Cushing Syndrome

NCT02019706

RECRUITING NA

New Heart Imaging Techniques to Evaluate Possible Heart Disease

NCT01399385

RECRUITING Phase 2

Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

NCT00977977

RECRUITING

Clinical and Genetic Studies in Familial Non-medullary Thyroid Cancer

NCT01109420

RECRUITING Phase 2

Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment

NCT00739362

RECRUITING

Natural History of Familial Carcinoid Tumor

NCT00646022

RECRUITING

Blood Sampling for Research Related to Sickle Cell Disease

NCT00542230

RECRUITING

Physical and Behavioral Traits of Overweight and Obese Adults

NCT00428987

RECRUITING

Urinary Vitamin C Loss in Diabetic Subjects

NCT00071526

RECRUITING

Family Investigation of Nephropathy and Diabetes (F.I.N.D.)

NCT00342927

RECRUITING

Diabetes and Heart Disease Risk in Blacks

NCT00001853

RECRUITING

Immune System Related Kidney Disease

NCT00001979

RECRUITING

Evaluation of Patients With Liver Disease

NCT00001971

RECRUITING

Diagnosing and Treating Low Blood Sugar Levels

NCT00001276

RECRUITING

Studies on Tumors of the Thyroid

NCT00001160

RECRUITING

Natural History of Thyroid Function Disorders

NCT00001159

RECRUITING

Genetic Studies of Insulin and Diabetes

NCT00001987

ACTIVE NOT RECRUITING Phase 2

Rituximab-pvvr and Abatacept vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes

NCT03929601

ACTIVE NOT RECRUITING Phase 2

Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)

NCT05743244

ACTIVE NOT RECRUITING Phase 4

People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents

NCT03520660

ACTIVE NOT RECRUITING Phase 2

Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy

NCT02262806

ACTIVE NOT RECRUITING Phase 3

Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy

NCT02262832

ACTIVE NOT RECRUITING Phase 2

Effect of Metreleptin Therapy in the Treatment of Severe Insulin Resistance

NCT00085982

COMPLETED

Study to Determine the Response to COVID-19 Vaccination and Prevalence of COVID-19 in Subjects With Chronic Liver Disease

NCT05669677

COMPLETED Phase 1

Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes

NCT02107976

COMPLETED Phase 1

Title: Therapeutic Targets in African-American Youth With Type 2 Diabetes

NCT02960659

COMPLETED

Longitudinal Assessment of Transient Elastography in Cystic Fibrosis

NCT03001388

COMPLETED Phase 2

Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extension

NCT02639286

COMPLETED

Dynamic Post-Prandial Metabolism in Patients With Non-Alcoholic Fatty Liver Disease

NCT02520609

COMPLETED

Quantifying the Persistence of Metabolic Adaptation and Weight Regain Following Extreme Weight Loss

NCT02544009

COMPLETED

Deciphering the Mechanisms Involved in Microbial Translocation Across the Spectrum of HCV Associated Liver Fibrosis

NCT02400216

COMPLETED

Palmitate Breath Test to Assess Fatty Acid Oxidation in Non Alcoholic Fatty Liver Disease (NAFLD)

NCT02363309

COMPLETED Phase 2

Add-on Peginterferon Following Nucleos(t)Ide Analogue Treatment

NCT02364336

COMPLETED

Comparing Pain in Patients Undergoing Percutaneous Versus Transjugular Techniques of Liver Biopsy

NCT02311348

COMPLETED Phase 1

Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women

NCT00862433

COMPLETED Phase 2

Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate

NCT01950520

COMPLETED

Evaluation of Sickle Cell Liver Disease

NCT01950429

COMPLETED

Identifying Risk for Diabetes and Heart Disease in Women

NCT01809288

COMPLETED NA

Predicting Adherence to a Heart-Healthy Diet in Lean and Obese Individuals

NCT01862796

COMPLETED Phase 2

New Treatment Response in People With and Without Cirrhosis From Chronic Hepatitis C

NCT01888900

COMPLETED Phase 3

Lifestyle Interventions for Expectant Mothers (LIFE-Moms Phoenix) - Phoenix

NCT01812694

COMPLETED

Evaluation of People With Gastrointestinal Disease

NCT01639924

COMPLETED Phase 2

The Farnesoid X Receptor (FXR) Ligand Obeticholic Acid in NASH Treatment Trial(FLINT)

NCT01265498

COMPLETED

TODAY2 Phase 1 Immediate Post-Intervention Observational Follow-up Study

NCT01364350

COMPLETED Phase 2

Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men

NCT01294319

COMPLETED Phase 1

Developing Biomarkers of Dietary Intake

NCT01237093

COMPLETED Phase 2

Teplizumab for Prevention of Type 1 Diabetes In Relatives "At-Risk"

NCT01030861

COMPLETED Phase 1

Quitting Caffeine for Better Glucose Metabolism

NCT01030796

COMPLETED Phase 2

Reduced Carbohydrate Versus Fat in Obese Subjects

NCT00846040

COMPLETED Phase 1

Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals

NCT00813228

COMPLETED

Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3

NCT00812149

COMPLETED Phase 1

Viral Kinetics and Liver Gene Expression in Response to Ribavirin and Peginterferon Therapy of Chronic Hepatitis C

NCT00718172

COMPLETED Early Phase 1

Antioxidant Treatment of Type 2 Diabetes

NCT00609102

COMPLETED

Intraperative Assessment of Renal Perfusion Using Infrared Imaging

NCT00595179

COMPLETED Phase 2

African American Study of Kidney Disease and Hypertension ABPM Pilot Study

NCT00582777

COMPLETED NA

Addressing Emotional and Cognitive Factors in Behavioral Weight Loss Treatment

NCT00533052

COMPLETED

The Stress-Hormone System in Alcohol-Dependent Subjects

NCT00536146

COMPLETED

Effect of Diet on Vascular Disease in Pre-Menopausal Women

NCT00484861

COMPLETED Phase 3

Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR)

NCT00405704

COMPLETED Phase 2

Botulinum Toxin Injection for the Management of BPH

NCT00451191

COMPLETED NA

Nutritional Intervention to Prevent Diabetes

NCT00333554

COMPLETED Phase 2

Polyunsaturated Fatty Acids (PUFA) in Diabetic Fatty Liver

NCT00323414

COMPLETED Phase 3

Efficacy & Safety Study of Pregabalin to Treat Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)

NCT00371033

COMPLETED Phase 2

Treatment of Uterine Fibroids With the Selective Progesterone Receptor Modulator CDB-2914

NCT00290251

COMPLETED Phase 3

Treatment of Nonalcoholic Fatty Liver Disease in Children (TONIC)

NCT00063635

COMPLETED Phase 2

Iron Depletion Therapy for Type 2 DM and NAFLD

NCT00230087

COMPLETED Phase 2

Effect of Omega-3 PUFA Supplementation in NAFLD Patients

NCT00230113

COMPLETED

Mechanisms of Diabetes Control After Weight Loss Surgery

NCT00571220

COMPLETED Phase 3

Efficacy of Amitriptyline for Painful Bladder Syndrome (PBS)

NCT00124306

COMPLETED NA

Development of Limited Contact CBT Treatment for IBS

NCT00248586

COMPLETED NA

Exercise and Pioglitazone for HIV-Metabolic Syndromes

NCT00639457

Phase Distribution

PhaseTrial count
Phase 1 14
Phase 2 65
Phase 3 13
Phase 4 6

What the Pipeline for National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Shows

According to the ClinicalTrials.gov registry, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is linked to 375 US clinical trials across every stage of research activity. Of those, 276 studies are currently recruiting — about 74% of the sponsor's indexed portfolio — and 93 are already marked complete, representing roughly 25% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

The phase mix for National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) reports 19 late-stage studies (Phase 3 and Phase 4 combined) and 79 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

The top therapeutic focus area indexed for National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is Obesity with 25 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial