National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Trial Pipeline
Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study
NCT06730113
VIR-2218 and Peginterferon Alfa-2a for Chronic Hepatitis B
NCT06092333
Desmopressin Stimulation Test Performance in ACTH-Dependent Cushing Syndrome
NCT06635629
Pilot Study of Isocaloric Time Restricted Eating on Ketone Metabolism and Immunoregulation
NCT06169137
Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change
NCT06325722
Variability In Mixed Meal Tests: Fixed Versus Adjusted to Energy Needs Caloric Dose
NCT06223555
Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate
NCT06044935
Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD)
NCT05996536
Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States
NCT05832229
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
NCT05545306
Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach
NCT04685200
Study of Growth Hormone Inhibition Using Pegvisomant in Severe Insulin Resistance
NCT05470504
A Natural History Study of Metabolic Sizing in Health and Disease
NCT05398783
Natural History of Pregnancy and Pregnancy Outcomes in Metreleptin-Treated vs Untreated Subjects With Lipodystrophy
NCT05419037
Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment
NCT05213598
Early Tracking of Childhood Health Determinants (ETCHED) Study
NCT03481829
Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake
NCT04799301
TReatment for ImmUne Mediated PathopHysiology
NCT04862221
Evaluation of Patients With Gastrointestinal Disease
NCT05041374
Natural History Study of Parathyroid Disorders
NCT04969926
The Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid Cancer
NCT04927416
The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer
NCT03841617
Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)
NCT03884075
Study of Endocrine-Related Conditions and Physiology
NCT03867448
Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks
NCT03374215
The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta3-Adrenergic Receptor Agonists
NCT03049462
Evaluation of Adults With Endocrine and Metabolic-Related Conditions
NCT02830308
Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and Its Role in Metabolism
NCT02692885
Natural History of Noncirrhotic Portal Hypertension
NCT02417740
Prospective Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Ectopic Cushing Syndrome
NCT02019706
New Heart Imaging Techniques to Evaluate Possible Heart Disease
NCT01399385
Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy
NCT00977977
Clinical and Genetic Studies in Familial Non-medullary Thyroid Cancer
NCT01109420
Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment
NCT00739362
Natural History of Familial Carcinoid Tumor
NCT00646022
Blood Sampling for Research Related to Sickle Cell Disease
NCT00542230
Physical and Behavioral Traits of Overweight and Obese Adults
NCT00428987
Urinary Vitamin C Loss in Diabetic Subjects
NCT00071526
Family Investigation of Nephropathy and Diabetes (F.I.N.D.)
NCT00342927
Diabetes and Heart Disease Risk in Blacks
NCT00001853
Immune System Related Kidney Disease
NCT00001979
Evaluation of Patients With Liver Disease
NCT00001971
Diagnosing and Treating Low Blood Sugar Levels
NCT00001276
Studies on Tumors of the Thyroid
NCT00001160
Natural History of Thyroid Function Disorders
NCT00001159
Genetic Studies of Insulin and Diabetes
NCT00001987
Rituximab-pvvr and Abatacept vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes
NCT03929601
Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)
NCT05743244
People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents
NCT03520660
Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy
NCT02262806
Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy
NCT02262832
Effect of Metreleptin Therapy in the Treatment of Severe Insulin Resistance
NCT00085982
Study to Determine the Response to COVID-19 Vaccination and Prevalence of COVID-19 in Subjects With Chronic Liver Disease
NCT05669677
Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes
NCT02107976
Title: Therapeutic Targets in African-American Youth With Type 2 Diabetes
NCT02960659
Longitudinal Assessment of Transient Elastography in Cystic Fibrosis
NCT03001388
Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extension
NCT02639286
Dynamic Post-Prandial Metabolism in Patients With Non-Alcoholic Fatty Liver Disease
NCT02520609
Quantifying the Persistence of Metabolic Adaptation and Weight Regain Following Extreme Weight Loss
NCT02544009
Deciphering the Mechanisms Involved in Microbial Translocation Across the Spectrum of HCV Associated Liver Fibrosis
NCT02400216
Palmitate Breath Test to Assess Fatty Acid Oxidation in Non Alcoholic Fatty Liver Disease (NAFLD)
NCT02363309
Add-on Peginterferon Following Nucleos(t)Ide Analogue Treatment
NCT02364336
Comparing Pain in Patients Undergoing Percutaneous Versus Transjugular Techniques of Liver Biopsy
NCT02311348
Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women
NCT00862433
Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate
NCT01950520
Evaluation of Sickle Cell Liver Disease
NCT01950429
Identifying Risk for Diabetes and Heart Disease in Women
NCT01809288
Predicting Adherence to a Heart-Healthy Diet in Lean and Obese Individuals
NCT01862796
New Treatment Response in People With and Without Cirrhosis From Chronic Hepatitis C
NCT01888900
Lifestyle Interventions for Expectant Mothers (LIFE-Moms Phoenix) - Phoenix
NCT01812694
Evaluation of People With Gastrointestinal Disease
NCT01639924
The Farnesoid X Receptor (FXR) Ligand Obeticholic Acid in NASH Treatment Trial(FLINT)
NCT01265498
TODAY2 Phase 1 Immediate Post-Intervention Observational Follow-up Study
NCT01364350
Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men
NCT01294319
Developing Biomarkers of Dietary Intake
NCT01237093
Teplizumab for Prevention of Type 1 Diabetes In Relatives "At-Risk"
NCT01030861
Quitting Caffeine for Better Glucose Metabolism
NCT01030796
Reduced Carbohydrate Versus Fat in Obese Subjects
NCT00846040
Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals
NCT00813228
Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3
NCT00812149
Viral Kinetics and Liver Gene Expression in Response to Ribavirin and Peginterferon Therapy of Chronic Hepatitis C
NCT00718172
Antioxidant Treatment of Type 2 Diabetes
NCT00609102
Intraperative Assessment of Renal Perfusion Using Infrared Imaging
NCT00595179
African American Study of Kidney Disease and Hypertension ABPM Pilot Study
NCT00582777
Addressing Emotional and Cognitive Factors in Behavioral Weight Loss Treatment
NCT00533052
The Stress-Hormone System in Alcohol-Dependent Subjects
NCT00536146
Effect of Diet on Vascular Disease in Pre-Menopausal Women
NCT00484861
Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR)
NCT00405704
Botulinum Toxin Injection for the Management of BPH
NCT00451191
Nutritional Intervention to Prevent Diabetes
NCT00333554
Polyunsaturated Fatty Acids (PUFA) in Diabetic Fatty Liver
NCT00323414
Efficacy & Safety Study of Pregabalin to Treat Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
NCT00371033
Treatment of Uterine Fibroids With the Selective Progesterone Receptor Modulator CDB-2914
NCT00290251
Treatment of Nonalcoholic Fatty Liver Disease in Children (TONIC)
NCT00063635
Iron Depletion Therapy for Type 2 DM and NAFLD
NCT00230087
Effect of Omega-3 PUFA Supplementation in NAFLD Patients
NCT00230113
Mechanisms of Diabetes Control After Weight Loss Surgery
NCT00571220
Efficacy of Amitriptyline for Painful Bladder Syndrome (PBS)
NCT00124306
Development of Limited Contact CBT Treatment for IBS
NCT00248586
Exercise and Pioglitazone for HIV-Metabolic Syndromes
NCT00639457
What the Pipeline for National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Shows
According to the ClinicalTrials.gov registry, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is linked to 375 US clinical trials across every stage of research activity. Of those, 276 studies are currently recruiting — about 74% of the sponsor's indexed portfolio — and 93 are already marked complete, representing roughly 25% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
The phase mix for National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) reports 19 late-stage studies (Phase 3 and Phase 4 combined) and 79 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
The top therapeutic focus area indexed for National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is Obesity with 25 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology — how this data is sourced, computed, and verified.