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2026 data Public-data reference. official source

Metastatic Pancreatic Adenocarcinoma

Open-data reference.

38 US clinical trials · 11 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 614 participants

A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer

Astellas Pharma Global Development

NCT07409272

RECRUITING Phase 3 480 participants

Glufosfamide Versus 5-FU in Second Line Metastatic Pancreatic Cancer

Eleison Pharmaceuticals

NCT01954992

RECRUITING NA 136 participants

Telehealth Self-Management Coaching Sessions to Improve Quality of Life in Pancreatic Cancer Survivors and Their Family Care Givers

City of Hope Medical Center

NCT06524973

RECRUITING Phase 3 94 participants

Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations

SWOG Cancer Research Network

NCT06998940

RECRUITING Phase 2 67 participants

Biologically Optimized Infusion Schedule of Gemcitabine and Nab-Paclitaxel for the Treatment of Metastatic Pancreatic Cancer

Anne Noonan

NCT04115163

RECRUITING Phase 2 52 participants

Evaluating NALIRIFOX vs Modified Gemcitabine, Nab-Paclitaxel and Cisplatin in Patients With Locally Advanced and Metastatic Pancreatic Adenocarcinoma

Medical University of South Carolina

NCT07076212

RECRUITING Phase 1 52 participants

TR-002 for the Treatment of Advanced, Unresectable or Metastatic Solid Tumors and Unresectable or Metastatic, Refractory Pancreatic Adenocarcinoma

University of California, Davis

NCT07189195

RECRUITING Phase 2 43 participants

BMS-986340 in Combination With Nivolumab, Gemcitabine and Nab-paclitaxel for the Treatment of Metastatic and Recurrent Pancreatic Adenocarcinoma

Mayo Clinic

NCT07226856

RECRUITING Phase 2 30 participants

Gemcitabine, Nab-paclitaxel Plus the TheraBionic P1 (an Amplitude-Modulated Radiofrequency Electromagnetic Fields) Device to Treat Metastatic Pancreatic Cancer

Barbara Ann Karmanos Cancer Institute

NCT06576115

RECRUITING Phase 1 28 participants

iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation

M.D. Anderson Cancer Center

NCT03608631

RECRUITING Phase 2 25 participants

Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advanced or Metastatic Pancreatic Cancer

Mayo Clinic

NCT06381154

ACTIVE NOT RECRUITING Phase 2 393 participants

A Study of Zolbetuximab (IMAB362) in Adults With Pancreatic Cancer

Astellas Pharma Global Development

NCT03816163

ACTIVE NOT RECRUITING Phase 2 176 participants

Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread

ECOG-ACRIN Cancer Research Group

NCT04233866

ACTIVE NOT RECRUITING Phase 2 123 participants

FOLFIRI or Modified FOLFIRI and Veliparib as Second Line Therapy in Treating Patients With Metastatic Pancreatic Cancer

National Cancer Institute (NCI)

NCT02890355

ACTIVE NOT RECRUITING Phase 2 122 participants

A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors

National Cancer Institute (NCI)

NCT02498613

ACTIVE NOT RECRUITING Phase 2 88 participants

Gemcitabine Hydrochloride and Cisplatin With or Without Veliparib or Veliparib Alone in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer

National Cancer Institute (NCI)

NCT01585805

ACTIVE NOT RECRUITING Phase 2 88 participants

Testing the Addition of Pembrolizumab, an Immunotherapy Cancer Drug to Olaparib Alone as Therapy for Patients With Pancreatic Cancer That Has Spread With Inherited BRCA Mutations

National Cancer Institute (NCI)

NCT04548752

ACTIVE NOT RECRUITING Phase 1 70 participants

A Study of Ivaltinostat Plus Capecitabine or Capecitabine in Metastatic Pancreatic Adenocarcinoma

CG Pharmaceuticals

NCT05249101

ACTIVE NOT RECRUITING Phase 1 64 participants

TAS102 in Combination With NAL-IRI in Advanced GI Cancers

Emory University

NCT03368963

ACTIVE NOT RECRUITING Phase 1 61 participants

Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors

University of Southern California

NCT02495896

ACTIVE NOT RECRUITING Phase 1 55 participants

Guadecitabine and Durvalumab in Treating Patients With Advanced Liver, Pancreatic, Bile Duct, or Gallbladder Cancer

University of Southern California

NCT03257761

ACTIVE NOT RECRUITING Phase 1 48 participants

Trial of Immunotherapy With Avelumab and Pepinemab As Second Line For Patients With Metastatic Pancreatic Adenocarcinoma

Vaccinex

NCT05102721

ACTIVE NOT RECRUITING Phase 1 44 participants

LEE011 Plus Everolimus in Patients With Metastatic Pancreatic Adenocarcinoma Refractory to Chemotherapy

Georgetown University

NCT02985125

ACTIVE NOT RECRUITING Phase 1 39 participants

Binimetinib and Hydroxychloroquine in Treating Patients With KRAS Mutant Metastatic Pancreatic Cancer

M.D. Anderson Cancer Center

NCT04132505

ACTIVE NOT RECRUITING Phase 1 28 participants

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer

National Cancer Institute (NCI)

NCT04514497

ACTIVE NOT RECRUITING Phase 1 22 participants

BATs Treatment for Pancreatic Cancer, Phase Ib/II

University of Virginia

NCT03269526

ACTIVE NOT RECRUITING Phase 1 19 participants

Gemcitabine Hydrochloride, Dasatinib, and Erlotinib Hydrochloride in Treating Patients With Pancreatic Cancer That Is Metastatic or Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT01660971

ACTIVE NOT RECRUITING Phase 1 18 participants

Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer

Academic and Community Cancer Research United

NCT03337087

ACTIVE NOT RECRUITING Phase 1 17 participants

Pancrelipase in People With Pancreatic Ductal Adenocarcinoma (PDAC)

Memorial Sloan Kettering Cancer Center

NCT05642962

ACTIVE NOT RECRUITING Phase 1 15 participants

Calaspargase Pegol-Mnkl and Cobimetinib for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer

OHSU Knight Cancer Institute

NCT05034627

ACTIVE NOT RECRUITING Phase 1 14 participants

Testing the Addition of an Anti-cancer Drug, Elimusertib (BAY 1895344) ATR Inhibitor, to the Chemotherapy Treatment (Gemcitabine) for Advanced Pancreatic and Ovarian Cancer, and Advanced Solid Tumors

National Cancer Institute (NCI)

NCT04616534

ACTIVE NOT RECRUITING Phase 1 12 participants

A Study of Zolbetuximab With Chemotherapy in Adults With Pancreatic Cancer

Astellas Pharma Global Development

NCT06396091

COMPLETED Phase 2 83 participants

FOLFIRINOX Followed by Ipilimumab With Pancreatic Tumor Vaccine in Treatment of Metastatic Pancreatic Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT01896869

COMPLETED Phase 2 41 participants

Epacadostat, Pembrolizumab, and CRS-207, With or Without CY/GVAX Pancreas in Patients With Metastatic Pancreas Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03006302

COMPLETED NA 39 participants

Medical Food for the Dietary Management of Advanced/Metastatic Pancreatic Cancer

Faeth Therapeutics

NCT05078775

COMPLETED Phase 2 19 participants

Study to Evaluate Efficacy of CO-1.01 as Second Line Therapy for Gemcitabine-Refractory Stage IV Pancreatic Adenocarcinoma

Clovis Oncology

NCT01233375

COMPLETED Phase 2 10 participants

Paricalcitol and Hydroxychloroquine in Combination With Gemcitabine and Nab-Paclitaxel for Advanced Pancreatic Cancer

Emory University

NCT04524702

COMPLETED Phase 1 2 participants

BATS With in Combination With Low Dose IL-1 and GM-CSF for Advanced Pancreatic Cancer

Barbara Ann Karmanos Cancer Institute

NCT02620865

Phase Distribution

PhaseTrial count
Early Phase 1 18
Phase 2 15
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Pancreatic Adenocarcinoma Trial Landscape

ClinicalTrials.gov lists 38 US studies indexed under Metastatic Pancreatic Adenocarcinoma, and 11 of those are currently open to recruitment — roughly 29% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Metastatic Pancreatic Adenocarcinoma shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 33 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Metastatic Pancreatic Adenocarcinoma is led by National Cancer Institute (NCI) with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 38 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Pancreatic Adenocarcinoma?

PlainTrial tracks 38 US clinical trials for Metastatic Pancreatic Adenocarcinoma, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Pancreatic Adenocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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