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NCT05653258 · ClinicalTrials.gov registry record · Phase 2
Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects
A Phase 2 study of Obesity and Healthy Lifestyle, sponsored by Cedars-Sinai Medical Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 160
- Enrollment target
- 1
- Study location
NCT05653258 is a Phase 2 study of Obesity and Healthy Lifestyle that is actively recruiting participants, run by Cedars-Sinai Medical Center. The registered enrollment target is 160 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (80% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05653258, a Phase 2 study of Obesity and Healthy Lifestyle, is actively recruiting participants, sponsored by Cedars-Sinai Medical Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 160 participants
- Enrollment target
- 1
- Study location
Study Summary
All participants will undergo baseline biopsies of subcutaneous abdominal adipose tissue for cellular/molecular profiling via snRNA-seq and metabolic/physiological assessments (insulin sensitivity, glucose tolerance, and β-cell function). Older obese participants will be randomized into three arms: lifestyle intervention (n=24), senolytics (n=24), or placebo (n=24).
Conditions Studied
Interventions
- DRUG Placebo
- OTHER Lifestyle Intervention
- DRUG Dasatinib 100 MG
- DRUG Quercetin 1000mg
- PROCEDURE Abdominal adipose tissue biopsy
Study Locations (1)
California
- Cedars Sinai Medical Center - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 160 participants |
| Start Date | 2023-10-17 |
| Est. Completion | 2028-02-01 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05653258
The ClinicalTrials.gov registry entry for NCT05653258 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 160 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (80% lower). The listed sponsor is Cedars-Sinai Medical Center, which has 339 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 5 interventions - of which Placebo is the first listed.
NCT05653258 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT05653258 about?
NCT05653258 is a clinical study titled "Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects". All participants will undergo baseline biopsies of subcutaneous abdominal adipose tissue for cellular/molecular profiling via snRNA-seq and metabolic/physiological assessments (insulin sensitivity, glucose tolerance, and β-cell function). Older obese participants will be randomized into three arms: ...
What is the current status of trial NCT05653258?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 160 participants. The study started on 2023-10-17. Estimated completion is 2028-02-01.
What conditions does trial NCT05653258 study?
This clinical trial studies the following conditions: Obesity, Healthy Lifestyle.
What interventions are being tested in trial NCT05653258?
The interventions under investigation include: Placebo (DRUG), Lifestyle Intervention (OTHER), Dasatinib 100 MG (DRUG), Quercetin 1000mg (DRUG), Abdominal adipose tissue biopsy (PROCEDURE).
Who is sponsoring clinical trial NCT05653258?
This trial is sponsored by Cedars-Sinai Medical Center, which has 339 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05653258 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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