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NCT05653258 · ClinicalTrials.gov registry record · Phase 2
Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects
A Phase 2 study of Obesity and Healthy Lifestyle, sponsored by Cedars-Sinai Medical Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 160
- Enrollment target
- 1
- Study location
NCT05653258: Recruiting Phase 2 study of Obesity and Healthy Lifestyle, sponsored by Cedars-Sinai Medical Center.
NCT05653258 is a Phase 2 study of Obesity and Healthy Lifestyle that is actively recruiting participants, run by Cedars-Sinai Medical Center. The registered enrollment target is 160 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (80% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05653258, a Phase 2 study of Obesity and Healthy Lifestyle, is actively recruiting participants, sponsored by Cedars-Sinai Medical Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 160 participants
- Enrollment target
- 1
- Study location
Study Summary
All participants will undergo baseline biopsies of subcutaneous abdominal adipose tissue for cellular/molecular profiling via snRNA-seq and metabolic/physiological assessments (insulin sensitivity, glucose tolerance, and β-cell function). Older obese participants will be randomized into three arms: lifestyle intervention (n=24), senolytics (n=24), or placebo (n=24).
Primary Outcome
Change in skeletal muscle insulin sensitivity
Conditions Studied
Interventions
- DRUG Placebo
- OTHER Lifestyle Intervention
- DRUG Dasatinib 100 MG
- DRUG Quercetin 1000mg
- PROCEDURE Abdominal adipose tissue biopsy
Study Locations (1)
California
- Cedars Sinai Medical Center - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 160 participants |
| Start Date | 2023-10-17 |
| Est. Completion | 2028-02-01 |
| Phase | Phase 2 |
What NCT05653258 shows while recruiting
NCT05653258 is an interventional study that assigns participants to a tested intervention. The registered 160 participants enrollment target is mid-sized for trials with a published cap, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (80% lower).
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 5 interventions - of which Placebo is the first listed.
NCT05653258 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05653258 about?
NCT05653258 is a clinical study titled "Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects". All participants will undergo baseline biopsies of subcutaneous abdominal adipose tissue for cellular/molecular profiling via snRNA-seq and metabolic/physiological assessments (insulin sensitivity, glucose tolerance, and β-cell function). Older obese participants will be randomized into three arms: ...
What is the current status of trial NCT05653258?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 160 participants. The study started on 2023-10-17. Estimated completion is 2028-02-01.
What conditions does trial NCT05653258 study?
This clinical trial studies the following conditions: Obesity, Healthy Lifestyle.
What interventions are being tested in trial NCT05653258?
The interventions under investigation include: Placebo (DRUG), Lifestyle Intervention (OTHER), Dasatinib 100 MG (DRUG), Quercetin 1000mg (DRUG), Abdominal adipose tissue biopsy (PROCEDURE).
Who is sponsoring clinical trial NCT05653258?
This trial is sponsored by Cedars-Sinai Medical Center, which has 339 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05653258 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obesity
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05653258's enrollment target sits among peer trials
160 359th of 1053 higher than 691 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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