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A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
NCT06672939 · View on ClinicalTrials.gov ↗
Study Summary
The main purpose of this study, performed under Master Protocol J4M-MC-PWMP, is to evaluate the efficacy, safety, and pharmacokinetics of orforglipron once daily oral versus Placebo in adolescent participants with obesity, or overweight with related comorbidities. Participation in the study will last about 18 months.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Orforglipron
Study Locations (20)
Other
- Shamir Medical Center — Beer Jacob
- Shaare Zedek Medical Center — Jerusalem
- Sheba Medical Center — Ramat Gan
- Azienda Ospedaliero Universitaria Meyer — Florence
- Azienda Ospedaliero Universitaria Maggiore della Carità — Novara
Texas
- Dynamed Clinical Research, LP d/b/a DM Clinical Research — Houston
- La Providence Pediatrics Clinic - Chemidox Clinical Trials — Houston
- Martin Diagnostic Clinic — Tomball
Connecticut
- Yale School of Medicine - Yale Diabetes Center (YDC)) Trials — New Haven
- Stamford Therapeutics Consortium — Stamford
California
- Carey Chronis MD Pediatric, Infant and Adolescent Medicine — Ventura
Georgia
- Children's Healthcare of Atlanta - Center for Advanced Pediatrics — Atlanta
Illinois
- Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago
Louisiana
- Velocity Clinical Research — Lafayette
Mississippi
- MedPharmics, LLC — Gulfport
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 125 participants |
| Start Date | 2024-11-18 |
| Est. Completion | 2027-03 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06672939
The ClinicalTrials.gov registry entry for NCT06672939 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 125 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06672939 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Other, Texas, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06672939 about?
NCT06672939 is a clinical study titled "A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities". The main purpose of this study, performed under Master Protocol J4M-MC-PWMP, is to evaluate the efficacy, safety, and pharmacokinetics of orforglipron once daily oral versus Placebo in adolescent participants with obesity, or overweight with related comorbidities. Participation in the study will las...
What is the current status of trial NCT06672939?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 125 participants. The study started on 2024-11-18. Estimated completion is 2027-03.
What conditions does trial NCT06672939 study?
This clinical trial studies the following conditions: Obesity, Overweight. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06672939?
The interventions under investigation include: Placebo (DRUG), Orforglipron (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06672939?
This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06672939 being conducted?
This trial has 20 study locations across California, Connecticut, Georgia, Illinois, Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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