Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT06814938 · ClinicalTrials.gov registry record · Phase 4

A Study of a Novel Precision Medicine Approach For Obesity

A Phase 4 study of Obesity, sponsored by Mayo Clinic.

Recruiting
Registry status
Phase 4
Development phase
135
Enrollment target
2
Study locations

NCT06814938: Recruiting Phase 4 study of Obesity, sponsored by Mayo Clinic.

NCT06814938 is a Phase 4 study of Obesity that is actively recruiting participants, run by Mayo Clinic. The registered enrollment target is 135 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (84% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT06814938, a Phase 4 study of Obesity, is actively recruiting participants, sponsored by Mayo Clinic.

RECRUITING
Registry status
Phase 4
Development phase
135 participants
Enrollment target
2
Study locations

Study Summary

This study is being done to assess the efficacy of a saliva- based biomarker to predict response to semaglutide for the treatment of obesity.

Primary Outcome

Percent change in body weight in biomarker positive participants vs. biomarker negative participants taking semaglutide vs placebo.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Semaglutide

Study Locations (2)

Florida

  • Mayo Clinic in Florida - Jacksonville

Minnesota

  • Mayo Clinic in Rochester - Rochester

Trial Details

FieldValue
Enrollment Target 135 participants
Start Date 2025-02-21
Est. Completion 2028-11
Phase Phase 4
Mayo Clinic

2,844 total trials

What NCT06814938 shows while recruiting

NCT06814938 is an interventional study that assigns participants to a tested intervention. The registered 135 participants enrollment target is mid-sized for trials with a published cap, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (84% lower).

The record links to 1 condition, with Obesity appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT06814938 reports a single indexed study location in Florida, Minnesota.

Frequently Asked Questions

What is clinical trial NCT06814938 about?

NCT06814938 is a clinical study titled "A Study of a Novel Precision Medicine Approach For Obesity". This study is being done to assess the efficacy of a saliva- based biomarker to predict response to semaglutide for the treatment of obesity.

What is the current status of trial NCT06814938?

This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 135 participants. The study started on 2025-02-21. Estimated completion is 2028-11.

What conditions does trial NCT06814938 study?

This clinical trial studies the following conditions: Obesity.

What interventions are being tested in trial NCT06814938?

The interventions under investigation include: Placebo (DRUG), Semaglutide (DRUG).

Who is sponsoring clinical trial NCT06814938?

This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06814938 being conducted?

This trial has 2 study locations across Florida, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Similar trials for Obesity

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT06814938's enrollment target sits among peer trials

135 414th of 1053 higher than 640 of 1,053 other Obesity trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT00870129 · 135 participants · NA

    Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors

  • NCT03666000 · 135 participants · Phase 1

    Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)

  • NCT04891510 · 135 participants · NA

    A Comparative Analysis of REVOLVE, LipoGrafter, and Viality in Autologous Fat Grafting During Breast Surgery

  • NCT05121051 · 135 participants · Phase 2

    Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers

Similar registry start date

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

  • NCT07125183 · started 2026-12 · Phase 2

    Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

  • NCT07292298 · started 2026-11 · Phase 2

    Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

  • NCT04263285 · started 2026-10 · NA

    Treatment of Depression Post-SCI

Source: ClinicalTrials.gov NCT06814938, the US trial registry maintained by the National Library of Medicine. NCT06814938 (mid enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.