Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06495710 · ClinicalTrials.gov registry record · NA
Arterial Stiffness and Blood Pressure
A NA study of Hypertension and Aging, sponsored by VA Office of Research and Development.
- Recruiting
- Registry status
- NA
- Development phase
- 228
- Enrollment target
- 3
- Study locations
NCT06495710: Recruiting NA study of Hypertension and Aging, sponsored by VA Office of Research and Development.
NCT06495710 is a NA study of Hypertension and Aging that is actively recruiting participants, run by VA Office of Research and Development. The registered enrollment target is 228 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (93% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06495710, a NA study of Hypertension and Aging, is actively recruiting participants, sponsored by VA Office of Research and Development.
- RECRUITING
- Registry status
- NA
- Development phase
- 228 participants
- Enrollment target
- 3
- Study locations
Study Summary
Hypertension is a common and treatable disorder that remains the leading preventable cause of heart disease. Blood pressure treatment relies mainly on upper arm blood pressure readings and ignores blood vessel physiology and underlying individual genetic information. Older Veterans with hypertension are less likely to be treated to goal blood pressure because there are conflicting recommendations for what constitutes "optimal" in older adults. The investigators have developed a novel way to non-invasively assess the components of blood vessel stiffness that is related to blood pressure (load-dependent stiffness). This project will generate new knowledge about how different blood pressure treatment goals (intensive vs standard) impact different components of arterial stiffness and if these differences can be explained through genetic analysis. Results from this project will offer the VA an updated blueprint for personalizing blood pressure care in older adults, ultimately improving cardiovascular health.
Primary Outcome
Load dependent stiffening is measured with ultrasound and tonometry and is the stiffness component due to elevated blood pressure increasing collagen fiber loading without an intrinsic change to the artery wall. The primary outcomes of load-dependent stiffness will be assessed at baseline and after 3, 6 and 12 months of guideline-based antihypertensive therapy.
Conditions Studied
Interventions
- OTHER Blood pressure treatment algorithm
Study Locations (3)
Alabama
- Birmingham VA Medical Center, Birmingham, AL - Birmingham
Tennessee
- Tennessee Valley Healthcare System Nashville Campus, Nashville, TN - Nashville
Wisconsin
- William S. Middleton Memorial Veterans Hospital, Madison, WI - Madison
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 228 participants |
| Start Date | 2025-05-01 |
| Est. Completion | 2028-12-31 |
| Phase | NA |
What NCT06495710 shows while recruiting
NCT06495710 is an interventional study that assigns participants to a tested intervention. The registered 228 participants enrollment target is mid-sized for trials with a published cap, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (93% lower).
The record links to 3 conditions, with Hypertension appearing as the primary indexed condition, and to 1 intervention - of which Blood pressure treatment algorithm is the first listed.
NCT06495710 reports a single indexed study location in Alabama, Tennessee, Wisconsin.
Frequently Asked Questions
What is clinical trial NCT06495710 about?
NCT06495710 is a clinical study titled "Arterial Stiffness and Blood Pressure". Hypertension is a common and treatable disorder that remains the leading preventable cause of heart disease. Blood pressure treatment relies mainly on upper arm blood pressure readings and ignores blood vessel physiology and underlying individual genetic information. Older Veterans with hypertension...
What is the current status of trial NCT06495710?
This trial is currently recruiting. It is a NA study. The enrollment target is 228 participants. The study started on 2025-05-01. Estimated completion is 2028-12-31.
What conditions does trial NCT06495710 study?
This clinical trial studies the following conditions: Hypertension, Aging, Vascular Stiffness.
What interventions are being tested in trial NCT06495710?
The interventions under investigation include: Blood pressure treatment algorithm (OTHER).
Who is sponsoring clinical trial NCT06495710?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06495710 being conducted?
This trial has 3 study locations across Alabama, Tennessee, Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06495710's enrollment target sits among peer trials
228 203rd of 470 higher than 268 of 470 other Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Ketone Ester And Salt (KEAS) in Older Adults
RECRUITING · NA
-
How a Mediterranean Diet With Potatoes Impacts Heart and Metabolic Health in Adults With Pre-Diabetes
RECRUITING · NA
-
Conical Forearm and Cylindrical Upper Arm Non-Invasive Blood Pressure (NIBP) Measurements in Pregnant Patients
RECRUITING · NA
-
Comparing Healthcare Visit Recording and Open Notes to Improve Chronic iLlness Care Experience in Older Adults
RECRUITING · NA
-
Early Time-Restricted Eating in Older Adults With Hypertension
RECRUITING · NA
-
Targeting Metabolic Syndrome From the Emergency Department Through Mixed-Methods: Pilot Trial
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT05107908 · 228 participants · NA
Neuronal and Behavioral Effects of an Implicit Priming Approach to Improve Eating Behaviors in Obesity
- NCT05547698 · 228 participants · NA
A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation
- NCT05630963 · 228 participants
Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression
- NCT06073665 · 228 participants · Phase 4
Dosing of LT4 in Older Individuals
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI