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NCT03888040 · ClinicalTrials.gov registry record · NA

Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and Women

A NA study of Aging, sponsored by Marquette University.

Recruiting
Registry status
NA
Development phase
120
Enrollment target
1
Study location

NCT03888040 is a NA study of Aging that is actively recruiting participants, run by Marquette University. The registered enrollment target is 120 participants, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT03888040, a NA study of Aging, is actively recruiting participants, sponsored by Marquette University.

RECRUITING
Registry status
NA
Development phase
120 participants
Enrollment target
1
Study location

Study Summary

The proposed studies will assess 1) the mechanisms for the age-related increase in fatigability during dynamic exercise (Aims 1 and 2) and 2) the effectiveness of high-velocity resistance training coupled with blood flow restriction (BFR) in improving muscle power output and fatigability in older adults (Aim 3). The first two aims are cross-sectional studies comparing young (18-35 years old) and older adults (≥60 yrs old) to test our central hypothesis that the greater accumulation of metabolites and increase in fatigability in older adults is due to either age-related impairments in skeletal muscle bioenergetics (Aim 1) and/or vascular dysfunction (Aim 2). These two aims will integrate techniques to assess whole-muscle bioenergetics (31P-MRS) and in vivo vascular function (near infrared spectroscopy; NIRS and doppler ultrasonography) with in vitro assessment of single fiber bioenergetics (epifluorescence microscopy) and vasoreactivity of isolated skeletal muscle arterioles (video microscopy). We will then determine whether bioenergetics, vascular function and fatigability are altered in older men and women in response to 8 weeks of resistance exercise training of the lower limb both with and without blood flow restriction (Aim 3).

Conditions Studied

Aging

Interventions

  • OTHER Exercise

Study Locations (1)

Wisconsin

  • Marquette University - Milwaukee

Trial Details

FieldValue
Enrollment Target 120 participants
Start Date 2020-09-01
Est. Completion 2025-08-31
Phase NA

Sponsor

Marquette University

27 total trials

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What the Registry Record Tells You About NCT03888040

The ClinicalTrials.gov registry entry for NCT03888040 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (95% lower). The listed sponsor is Marquette University, which has 27 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Aging appearing as the primary indexed condition, and to 1 intervention - of which Exercise is the first listed.

NCT03888040 reports 1 study location spanning 1 distinct geographic area - top geographies include Wisconsin.

Frequently Asked Questions

What is clinical trial NCT03888040 about?

NCT03888040 is a clinical study titled "Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and Women". The proposed studies will assess 1) the mechanisms for the age-related increase in fatigability during dynamic exercise (Aims 1 and 2) and 2) the effectiveness of high-velocity resistance training coupled with blood flow restriction (BFR) in improving muscle power output and fatigability in older ad...

What is the current status of trial NCT03888040?

This trial is currently recruiting. It is a NA study. The enrollment target is 120 participants. The study started on 2020-09-01. Estimated completion is 2025-08-31.

What conditions does trial NCT03888040 study?

This clinical trial studies the following conditions: Aging.

What interventions are being tested in trial NCT03888040?

The interventions under investigation include: Exercise (OTHER).

Who is sponsoring clinical trial NCT03888040?

This trial is sponsored by Marquette University, which has 27 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT03888040 being conducted?

This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.