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NCT03888040 · ClinicalTrials.gov registry record · NA
Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and Women
A NA study of Aging, sponsored by Marquette University.
- Recruiting
- Registry status
- NA
- Development phase
- 120
- Enrollment target
- 1
- Study location
NCT03888040: Recruiting NA study of Aging, sponsored by Marquette University.
NCT03888040 is a NA study of Aging that is actively recruiting participants, run by Marquette University. The registered enrollment target is 120 participants, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03888040, a NA study of Aging, is actively recruiting participants, sponsored by Marquette University.
- RECRUITING
- Registry status
- NA
- Development phase
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
The proposed studies will assess 1) the mechanisms for the age-related increase in fatigability during dynamic exercise (Aims 1 and 2) and 2) the effectiveness of high-velocity resistance training coupled with blood flow restriction (BFR) in improving muscle power output and fatigability in older adults (Aim 3). The first two aims are cross-sectional studies comparing young (18-35 years old) and older adults (≥60 yrs old) to test our central hypothesis that the greater accumulation of metabolites and increase in fatigability in older adults is due to either age-related impairments in skeletal muscle bioenergetics (Aim 1) and/or vascular dysfunction (Aim 2). These two aims will integrate techniques to assess whole-muscle bioenergetics (31P-MRS) and in vivo vascular function (near infrared spectroscopy; NIRS and doppler ultrasonography) with in vitro assessment of single fiber bioenergetics (epifluorescence microscopy) and vasoreactivity of isolated skeletal muscle arterioles (video microscopy). We will then determine whether bioenergetics, vascular function and fatigability are altered in older men and women in response to 8 weeks of resistance exercise training of the lower limb both with and without blood flow restriction (Aim 3).
Conditions Studied
Interventions
- OTHER Exercise
Study Locations (1)
Wisconsin
- Marquette University - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2020-09-01 |
| Est. Completion | 2025-08-31 |
| Phase | NA |
What NCT03888040 shows while recruiting
NCT03888040 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Aging appearing as the primary indexed condition, and to 1 intervention - of which Exercise is the first listed.
NCT03888040 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT03888040 about?
NCT03888040 is a clinical study titled "Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and Women". The proposed studies will assess 1) the mechanisms for the age-related increase in fatigability during dynamic exercise (Aims 1 and 2) and 2) the effectiveness of high-velocity resistance training coupled with blood flow restriction (BFR) in improving muscle power output and fatigability in older ad...
What is the current status of trial NCT03888040?
This trial is currently recruiting. It is a NA study. The enrollment target is 120 participants. The study started on 2020-09-01. Estimated completion is 2025-08-31.
What conditions does trial NCT03888040 study?
This clinical trial studies the following conditions: Aging.
What interventions are being tested in trial NCT03888040?
The interventions under investigation include: Exercise (OTHER).
Who is sponsoring clinical trial NCT03888040?
This trial is sponsored by Marquette University, which has 27 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03888040 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Aging
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03888040's enrollment target sits among peer trials
120 70th of 262 higher than 188 of 262 other Aging trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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