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Targeting Aging With a Ketone Ester for Function in Frailty
NCT06645847 · View on ClinicalTrials.gov ↗
Study Summary
This study aims to find out if a food supplement that contains a naturally occurring substance, ketones, can help to improve strength and general wellness in adults at, or over the age of 65 years who are experiencing a slight decline in their physical function. Participation will involve a screening visit and 4 additional study visits over the course of 20 weeks. After being assessed for eligibility, study participants will be sorted into two groups at random and consume either a ketone or placebo supplement at home every day for 20 weeks. Both study products can cause gastro-intestinal side effects in some individuals. At all study visits, subjects will provide blood samples. At three study visits, subjects will be asked to complete physical performance tests, provide blood, stool and urine samples. They will also complete questionnaires during three study visits to assess physical function, markers of inflammation, and other aspects of general well-being. The study enrolls at three sites across the United States, in California (Buck Institute), Ohio (Ohio State University), and Connecticut (University of Connecticut). The study is coordinated by the San Francisco Coordinating Center (California Pacific Medical Center).
Conditions Studied
Interventions
- OTHER Ketone ester
- OTHER Placebo Comparator: Non-ketone placebo
Study Locations (3)
California
- Buck Institute for Research on Aging — Novato
Connecticut
- UConn Health — Farmington
Ohio
- Ohio State University — Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2025-02-05 |
| Est. Completion | 2028-04-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06645847
The ClinicalTrials.gov registry entry for NCT06645847 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Buck Institute for Research on Aging, which has 5 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Aging appearing as the primary indexed condition, and to 2 interventions — of which Ketone ester is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06645847 reports 3 study locations spanning 3 distinct geographic areas — top geographies include California, Connecticut, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06645847 about?
NCT06645847 is a clinical study titled "Targeting Aging With a Ketone Ester for Function in Frailty". This study aims to find out if a food supplement that contains a naturally occurring substance, ketones, can help to improve strength and general wellness in adults at, or over the age of 65 years who are experiencing a slight decline in their physical function. Participation will involve a screeni...
What is the current status of trial NCT06645847?
This trial is currently recruiting. It is a NA study. The enrollment target is 180 participants. The study started on 2025-02-05. Estimated completion is 2028-04-01.
What conditions does trial NCT06645847 study?
This clinical trial studies the following conditions: Aging, Frail Elderly, Immune Function, Muscle Function. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06645847?
The interventions under investigation include: Ketone ester (OTHER), Placebo Comparator: Non-ketone placebo (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06645847?
This trial is sponsored by Buck Institute for Research on Aging, which has 5 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06645847 being conducted?
This trial has 3 study locations across California, Connecticut, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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