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NCT05574634 · ClinicalTrials.gov registry record · NA
The Role of the Locus Coeruleus in Age-related Distractibility
A NA study of Alzheimer Disease and Aging, sponsored by Virginia Polytechnic Institute and State University.
- Recruiting
- Registry status
- NA
- Development phase
- 200
- Enrollment target
- 1
- Study location
NCT05574634: Recruiting NA study of Alzheimer Disease and Aging, sponsored by Virginia Polytechnic Institute and State University.
NCT05574634 is a NA study of Alzheimer Disease and Aging that is actively recruiting participants, run by Virginia Polytechnic Institute and State University. The registered enrollment target is 200 participants, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05574634, a NA study of Alzheimer Disease and Aging, is actively recruiting participants, sponsored by Virginia Polytechnic Institute and State University.
- RECRUITING
- Registry status
- NA
- Development phase
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these declines are still largely unclear. The objective of this proposal is to investigate neural mechanisms of age-related attentional distractibility, focusing on the neural circuit initiated from the locus coeruleus (LC). In the current proposal, the investigators will test the hypothesis that the neural disconnectivity of LC with the salience network (SN) drives failures of ignoring distractors in older adults. The investigators will examine how LC-SN connectivity is associated with selective attention performance, and how improved LC-SN connectivity through a cognitive training program may lead to improved attentional performance.
Primary Outcome
During this task, participants will be presented to with target place stimuli overlaid on nonexpressive faces) and be asked to identify categories of place images ('building' to 'house') selectively as soon as possible while ignoring overlapped faces. The investigators will also include place only images to measure participants' baseline neural activation when there is no distractor. Each image condition will be presented in a mixed event related design that includes 15 blocks for each condition
Conditions Studied
Interventions
- BEHAVIORAL Tablet based adaptive multimodal attention practice program
- BEHAVIORAL Tablet based adaptive criterion task practice program
Study Locations (1)
Virginia
- Virginia Polytechnic Institute and State University - Blacksburg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2023-04-11 |
| Est. Completion | 2027-06-30 |
| Phase | NA |
What NCT05574634 shows while recruiting
NCT05574634 is an interventional study that assigns participants to a tested intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (93% lower).
The record links to 2 conditions, with Alzheimer Disease appearing as the primary indexed condition, and to 2 interventions - of which Tablet based adaptive multimodal attention practice program is the first listed.
NCT05574634 reports a single indexed study location in Virginia.
Frequently Asked Questions
What is clinical trial NCT05574634 about?
NCT05574634 is a clinical study titled "The Role of the Locus Coeruleus in Age-related Distractibility". A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these declin...
What is the current status of trial NCT05574634?
This trial is currently recruiting. It is a NA study. The enrollment target is 200 participants. The study started on 2023-04-11. Estimated completion is 2027-06-30.
What conditions does trial NCT05574634 study?
This clinical trial studies the following conditions: Alzheimer Disease, Aging.
What interventions are being tested in trial NCT05574634?
The interventions under investigation include: Tablet based adaptive multimodal attention practice program (BEHAVIORAL), Tablet based adaptive criterion task practice program (BEHAVIORAL).
Who is sponsoring clinical trial NCT05574634?
This trial is sponsored by Virginia Polytechnic Institute and State University, which has 104 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05574634 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05574634's enrollment target sits among peer trials
200 105th of 306 higher than 196 of 306 other Alzheimer Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alzheimer Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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