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NCT05597124 · ClinicalTrials.gov registry record · Phase 2
Exercise to Improve Brain Health in Older African Americans
A Phase 2 study of Alzheimer Disease and Aging, sponsored by Rutgers, The State University of New Jersey.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 280
- Enrollment target
- 1
- Study location
NCT05597124: Recruiting Phase 2 study of Alzheimer Disease and Aging, sponsored by Rutgers, The State University of New Jersey.
NCT05597124 is a Phase 2 study of Alzheimer Disease and Aging that is actively recruiting participants, run by Rutgers, The State University of New Jersey. The registered enrollment target is 280 participants, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05597124, a Phase 2 study of Alzheimer Disease and Aging, is actively recruiting participants, sponsored by Rutgers, The State University of New Jersey.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 280 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans. Specifically, the main question\[s\] it aims to answer are: * What is the effect of a Cardio-Dance Fitness (CDF) vs. a Strength, Flexibility, and Balance (SFB) intervention on a cognitive marker of Alzheimer's risk, generalization? * What is the effect of the CDF vs. SFB intervention on a fMRI biomarker of Alzheimer's, neural flexibility, and do improvements in neural flexibility mediate improvements in generalization? * Do ABCA7 genotypic variations moderate the efficacy of the CDF vs. SFB intervention for reducing Alzheimer's risk? Participants will undergo-- at baseline and post-test-- health assessments, cognitive tests, and structural and functional magnetic resonance imaging (fMRI), and a blood-draw to assess Alzheimer's risk biomarker levels.
Primary Outcome
The Concurrent Discrimination and Transfer Task (a task that indexes generalization, the ability to apply past learning to novel task demands) will be administered at baseline, and then following the intervention (6-months). The main outcome from this task is the number transfer errors. A higher score indicates worse generalization.
Conditions Studied
Interventions
- BEHAVIORAL Cardio-Dance Fitness
- BEHAVIORAL Strength, Flexibility & Balance
Study Locations (1)
New Jersey
- Rutgers, The State University of New Jersey - Newark campus - Newark
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 280 participants |
| Start Date | 2023-04-20 |
| Est. Completion | 2027-08-31 |
| Phase | Phase 2 |
What NCT05597124 shows while recruiting
NCT05597124 is an interventional study that assigns participants to a tested intervention. The registered 280 participants enrollment target is mid-sized for trials with a published cap, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (90% lower).
The record links to 4 conditions, with Alzheimer Disease appearing as the primary indexed condition, and to 2 interventions - of which Cardio-Dance Fitness is the first listed.
NCT05597124 reports a single indexed study location in New Jersey.
Frequently Asked Questions
What is clinical trial NCT05597124 about?
NCT05597124 is a clinical study titled "Exercise to Improve Brain Health in Older African Americans". The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans. Specifically, the main question\[s\] it aims to answer are: * What is the effect of a Cardio-Dance Fitness (CDF) vs. a Strength, Flexibility, and B...
What is the current status of trial NCT05597124?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 280 participants. The study started on 2023-04-20. Estimated completion is 2027-08-31.
What conditions does trial NCT05597124 study?
This clinical trial studies the following conditions: Alzheimer Disease, Aging, Cognitive Change, Healthy Aging.
What interventions are being tested in trial NCT05597124?
The interventions under investigation include: Cardio-Dance Fitness (BEHAVIORAL), Strength, Flexibility & Balance (BEHAVIORAL).
Who is sponsoring clinical trial NCT05597124?
This trial is sponsored by Rutgers, The State University of New Jersey, which has 413 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05597124 being conducted?
This trial has 1 study location across New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alzheimer Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05597124's enrollment target sits among peer trials
280 85th of 306 higher than 222 of 306 other Alzheimer Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alzheimer Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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