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NCT06912984 · ClinicalTrials.gov registry record · NA
Heterogeneity of Vascular Adaptations to Exercise With Aging in Women and Men
A NA study of Aging and Physical Activity, sponsored by University of Colorado, Denver.
- Recruiting
- Registry status
- NA
- Development phase
- 242
- Enrollment target
- 1
- Study location
NCT06912984: Recruiting NA study of Aging and Physical Activity, sponsored by University of Colorado, Denver.
NCT06912984 is a NA study of Aging and Physical Activity that is actively recruiting participants, run by University of Colorado, Denver. The registered enrollment target is 242 participants, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06912984, a NA study of Aging and Physical Activity, is actively recruiting participants, sponsored by University of Colorado, Denver.
- RECRUITING
- Registry status
- NA
- Development phase
- 242 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of the proposed study is to understand the reasons for the variability in aerobic exercise (AE) training benefits on the vasculature in middle-age and older (MA/O) adults, including differences between men and women. To achieve this goal, a mechanistic randomized controlled (RCT) will be conducted, in which adults are randomized to 12-weeks intervention of AE or no-exercise Control. Our overall hypothesis is that the exercise response variation in vascular benefits is related to age and sex differences in the biological changes underlying vascular aging and/or the molecular transducers (i.e., circulating molecules) that communicate and coordinate the effects of AE on the vasculature in the periphery and brain. Because this is a mechanistic trial, the overall goal is not a single health-related outcome. Rather, the goal is to advance our understanding of the molecular signals and pathways underlying the systemic and local effects of AE on vascular health that may explain the variability in AE responses with age and sex. This knowledge will allow for the development of personalized age- and sex-specific AE recommendations, and/or provide insights into molecular targets that can be manipulated to enhance and/or mimic exercise in non-responders or in persons unable to exercise.
Primary Outcome
Changes in brachial artery flow-mediated dilation calculated as %
Conditions Studied
Interventions
- BEHAVIORAL Aerobic Exercise Training
Study Locations (1)
Colorado
- University of Colorado Anschutz Medical Center, Clinical Translational Research Center and Exercise Research Laboratory - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 242 participants |
| Start Date | 2025-05-28 |
| Est. Completion | 2029-07-31 |
| Phase | NA |
What NCT06912984 shows while recruiting
NCT06912984 is an interventional study that assigns participants to a tested intervention. The registered 242 participants enrollment target is mid-sized for trials with a published cap, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (89% lower).
The record links to 3 conditions, with Aging appearing as the primary indexed condition, and to 1 intervention - of which Aerobic Exercise Training is the first listed.
NCT06912984 reports a single indexed study location in Colorado.
Frequently Asked Questions
What is clinical trial NCT06912984 about?
NCT06912984 is a clinical study titled "Heterogeneity of Vascular Adaptations to Exercise With Aging in Women and Men". The goal of the proposed study is to understand the reasons for the variability in aerobic exercise (AE) training benefits on the vasculature in middle-age and older (MA/O) adults, including differences between men and women. To achieve this goal, a mechanistic randomized controlled (RCT) will be co...
What is the current status of trial NCT06912984?
This trial is currently recruiting. It is a NA study. The enrollment target is 242 participants. The study started on 2025-05-28. Estimated completion is 2029-07-31.
What conditions does trial NCT06912984 study?
This clinical trial studies the following conditions: Aging, Physical Activity, Vascular Health.
What interventions are being tested in trial NCT06912984?
The interventions under investigation include: Aerobic Exercise Training (BEHAVIORAL).
Who is sponsoring clinical trial NCT06912984?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06912984 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06912984's enrollment target sits among peer trials
242 41st of 262 higher than 222 of 262 other Aging trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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