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NCT04911491 · ClinicalTrials.gov registry record · NA
Inspiratory Muscle Strength Training in Chronic Kidney Disease
A NA study of Hypertension and Aging, sponsored by University of Colorado, Denver.
- Recruiting
- Registry status
- NA
- Development phase
- 108
- Enrollment target
- 1
- Study location
NCT04911491: Recruiting NA study of Hypertension and Aging, sponsored by University of Colorado, Denver.
NCT04911491 is a NA study of Hypertension and Aging that is actively recruiting participants, run by University of Colorado, Denver. The registered enrollment target is 108 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04911491, a NA study of Hypertension and Aging, is actively recruiting participants, sponsored by University of Colorado, Denver.
- RECRUITING
- Registry status
- NA
- Development phase
- 108 participants
- Enrollment target
- 1
- Study location
Study Summary
More than 80% of individuals with chronic kidney disease have concomitant hypertension and the majority fail to achieve blood pressure control \<130/80 mmHg, leading to high risk of cardiovascular diseases and end-stage kidney disease. A stepwise combination of lifestyle modifications and drug therapy is recommended to lower blood pressure; however, adherence to time-intensive lifestyle interventions such as aerobic exercise in patients with chronic kidney disease is poor. This clinical trial seeks to establish the efficacy of high-resistance inspiratory muscle strength training, a novel time-efficient lifestyle intervention, for lowering systolic blood pressure and improving endothelial function in midlife and older adults with moderate-to-severe chronic kidney disease and inadequately controlled hypertension, and to use innovate translational assessments to understand the mechanisms involved.
Primary Outcome
Casual (resting) measures of systolic blood pressure (mmHg) will be measured in triplicate over the brachial artery of the non-dominant arm after 5 minutes of quiet rest, with 1 minute of recovery between each measure, using an automated oscillometric sphygmomanometer.
Conditions Studied
Interventions
- DEVICE Sham Training
- DEVICE IMST
Study Locations (1)
Colorado
- University of Colorado - Anschutz Medical Campus - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 108 participants |
| Start Date | 2022-03-01 |
| Est. Completion | 2026-07-01 |
| Phase | NA |
What NCT04911491 shows while recruiting
NCT04911491 is an interventional study that assigns participants to a tested intervention. The registered 108 participants enrollment target is mid-sized for trials with a published cap, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (97% lower).
The record links to 4 conditions, with Hypertension appearing as the primary indexed condition, and to 2 interventions - of which Sham Training is the first listed.
NCT04911491 reports a single indexed study location in Colorado.
Frequently Asked Questions
What is clinical trial NCT04911491 about?
NCT04911491 is a clinical study titled "Inspiratory Muscle Strength Training in Chronic Kidney Disease". More than 80% of individuals with chronic kidney disease have concomitant hypertension and the majority fail to achieve blood pressure control \<130/80 mmHg, leading to high risk of cardiovascular diseases and end-stage kidney disease. A stepwise combination of lifestyle modifications and drug thera...
What is the current status of trial NCT04911491?
This trial is currently recruiting. It is a NA study. The enrollment target is 108 participants. The study started on 2022-03-01. Estimated completion is 2026-07-01.
What conditions does trial NCT04911491 study?
This clinical trial studies the following conditions: Hypertension, Aging, Blood Pressure, Chronic Kidney Diseases.
What interventions are being tested in trial NCT04911491?
The interventions under investigation include: Sham Training (DEVICE), IMST (DEVICE).
Who is sponsoring clinical trial NCT04911491?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04911491 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04911491's enrollment target sits among peer trials
108 285th of 470 higher than 184 of 470 other Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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