The Cleveland Clinic

688 total trials 99 currently recruiting 437 completed

The Cleveland Clinic sponsors 688 registered US clinical trials on ClinicalTrials.gov, 99 of them currently recruiting, and 437 completed. 81 of these trials are in Phase 3-4 (later-stage) and 76 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atrial Fibrillation, with 9 trials.

Trial Pipeline

688 total, page 3 of 14

ACTIVE NOT RECRUITING

Continuous Glucose Monitoring in Polycystic Ovarian Syndrome

NCT07392476

ACTIVE NOT RECRUITING Phase 4

Sequential or CombinaTion Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial)

NCT06854614

ACTIVE NOT RECRUITING

Shifting Options Study

NCT07225595

ACTIVE NOT RECRUITING Early Phase 1

Comparison of Angiotensin II to Standard Dose Vasopressors on Change in Arterial Elastance

NCT07568275

ACTIVE NOT RECRUITING NA

Physiological Effects Ketone Ester in Heart

NCT05924802

ACTIVE NOT RECRUITING

Microbial Metabolites and Outcomes of Pregnancy Study

NCT06362356

ACTIVE NOT RECRUITING NA

3D Holographic Guidance, Navigation, and Control for Endovascular Aortic Repair

NCT06008613

ACTIVE NOT RECRUITING

Abdominal Wall Tension in Patients Undergoing Ventral Hernia Repair Without Component Separation

NCT06051578

ACTIVE NOT RECRUITING NA

VIRtual Versus UsuAL In-office Care for Multiple Sclerosis (VIRTUAL-MS)

NCT05660187

ACTIVE NOT RECRUITING

Glycemic Control, Type II Diabetes, Parathyroidectomy

NCT05761743

ACTIVE NOT RECRUITING

The Use of Genex in the Management of Early-Stage Osteonecrosis of the Femoral Head

NCT05706909

ACTIVE NOT RECRUITING NA

Reducing Antimicrobial Overuse Through Targeted Therapy for Patients With Community-Acquired Pneumonia

NCT05568654

ACTIVE NOT RECRUITING NA

Impact of Surgical Coaching on Resident ObGyn Laparoscopic Skills

NCT05911165

ACTIVE NOT RECRUITING NA

Randomized Controlled Trial of Digital Twin Precision Treatment: A Novel Whole Body Digital Twin Enabled Precision Treatment for Type 2 Diabetes

NCT05181449

ACTIVE NOT RECRUITING

Variation in Humeral Head Bone Marrow Characteristics With Rotator Cuff Repair Healing

NCT05106088

ACTIVE NOT RECRUITING NA

CYCLE-AD (CYcling to Cease or Limit the Effects of Alzheimer's Disease)

NCT04748861

ACTIVE NOT RECRUITING NA

Low Tidal Volume Ventilation With Hyperoxia Avoidance During Cardiopulmonary Bypass (The FOCUS Trial)

NCT04978636

ACTIVE NOT RECRUITING NA

A Comparison of ACL Repair With BEAR Device vs. Autograft Patellar Tendon ACL Reconstruction

NCT03776162

ACTIVE NOT RECRUITING Phase 4

Corticosteroid Meniscectomy Randomized Trial

NCT04641351

ACTIVE NOT RECRUITING NA

Operating Room Air Filtration/Sterilization

NCT04610294

ACTIVE NOT RECRUITING NA

Virtual and Video Counseling Versus In-Office Counseling for Laparoscopic Hysterectomy

NCT05086406

ACTIVE NOT RECRUITING

Volatile Organic Compounds (VOCs) in Active Inflammatory Bowel Disease

NCT04827368

ACTIVE NOT RECRUITING NA

Consumption of Oral Artificial Sweeteners on Platelet Aggregation and Polyol Excretion

NCT04731363

ACTIVE NOT RECRUITING NA

Analysis of MicroBial Metabolites After Eating Refined Food

NCT04308473

ACTIVE NOT RECRUITING

RHYTHMIA vs CARTO in Redo Ablation Procedures for Atrial Fibrillation

NCT04835844

ACTIVE NOT RECRUITING

CASE 1320: RAI Uptake and Serum Prolactin in Thyroid Cancer

NCT04495985

ACTIVE NOT RECRUITING

Central Vein Sign: a Diagnostic Biomarker in Multiple Sclerosis

NCT04495556

ACTIVE NOT RECRUITING NA

Oral Sodium to Preserve Renal EfficiencY in Acute Heart Failure

NCT04334668

ACTIVE NOT RECRUITING NA

Implementation of a Clinical Tool to Improve Waitlist Mortality in Patients With Cystic Fibrosis

NCT04687475

ACTIVE NOT RECRUITING Early Phase 1

Preoperative Tamsulosin to Prevent Postoperative Urinary Retention After Surgery For Pelvic Floor Disorders

NCT04232683

ACTIVE NOT RECRUITING Phase 3

Perioperative Lidocaine and Ketamine in Abdominal Surgery

NCT04084548

ACTIVE NOT RECRUITING

Imaging Quantification of Inflammation (IQI)

NCT04704609

ACTIVE NOT RECRUITING Phase 4

Determining the Effectiveness of earLy Intensive Versus Escalation Approaches for RRMS

NCT03535298

ACTIVE NOT RECRUITING NA

Pulmonary Arterial Hypertension Improvement With Nutrition and Exercise (PHINE)

NCT03288025

ACTIVE NOT RECRUITING

Quantitative MRI for Non-invasive Assessment of Severity of Alcoholic Liver Disease (ALD)

NCT03113929

ACTIVE NOT RECRUITING

Pulmonary Vascular Disease Phenomics Program PVDOMICS

NCT02980887

ACTIVE NOT RECRUITING

Rotator Cuff Failure With Continuity

NCT02716441

ACTIVE NOT RECRUITING NA

Uterine Transplantation for the Treatment of Uterine Factor Infertility

NCT02573415

ACTIVE NOT RECRUITING

Airway Redox and Gender Determinants in Severe Asthma

NCT01759186

ACTIVE NOT RECRUITING Early Phase 1

CARNIVAL Study: Gut Flora Dependent Metabolism of Dietary CARNItine and Phosphatidylcholine and cardioVAscuLar Disease

NCT01731236

ACTIVE NOT RECRUITING

Cleveland Heart and Metabolic Prevention Study

NCT03012022

ACTIVE NOT RECRUITING

Identification of Genetic, Biochemical and Hormonal Factors Contributing to Atrial Fibrillation

NCT00599118

NOT YET RECRUITING NA

Shape-sensing Versus Electromagnetic Robotic Bronchoscopy for Evaluation of PulmoNary LEsions

NCT07411989

NOT YET RECRUITING NA

Youth Suicide Prevention: CAMS-BI vs. Safety Planning in a Randomized Trial

NCT07628192

NOT YET RECRUITING

Imaging in Semaglutide Study

NCT07695454

NOT YET RECRUITING NA

Clinical Decision Support Tool for the Treatment of Uncontrolled Hypertension

NCT07218198

NOT YET RECRUITING Early Phase 1

Self-Start Triage Model for Post-Botox® Lower Urinary Tract Symptoms

NCT07648290

NOT YET RECRUITING NA

Neural Correlates of Suicidal Behavior in Youth

NCT07568054

NOT YET RECRUITING Phase 3

Bone Marrow Aspirate Concentrate Versus Triamcinolone Injection For Hip Osteoarthritis

NCT04990128

TERMINATED

Vasopressin Hemodynamic Response as a Septic Shock Subphenotype Indicator

NCT06426407

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Phase Distribution

PhaseTrial count
Phase 1 38
Phase 2 38
Phase 3 22
Phase 4 59

What the Pipeline for The Cleveland Clinic Shows

According to the ClinicalTrials.gov registry, The Cleveland Clinic is linked to 688 US clinical trials across every stage of research activity. Of those, 99 studies are currently recruiting, about 14% of the sponsor's indexed portfolio, and 437 are already marked complete, representing roughly 64% of the total.

The phase mix for The Cleveland Clinic reports 81 late-stage studies (Phase 3 and Phase 4 combined) and 76 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for The Cleveland Clinic is Atrial Fibrillation with 9 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.