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NCT07568054 · ClinicalTrials.gov registry record · NA
Neural Correlates of Suicidal Behavior in Youth
A NA study, sponsored by The Cleveland Clinic.
- Not yet
- Registry status
- NA
- Development phase
- 60
- Enrollment target
NCT07568054: Clinical Trial NA study, sponsored by The Cleveland Clinic.
NCT07568054 is a NA study that has not yet begun recruiting, run by The Cleveland Clinic. The registered enrollment target is 60 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07568054, a NA study, has not yet begun recruiting, sponsored by The Cleveland Clinic.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
Study Summary
This study, titled "Neural Correlates of Suicidal Behavior in Youth: a Pre and Post CAMS Therapy Neuroimaging Study," aims to better understand the brain mechanisms underlying suicidal thoughts and behaviors in adolescents and young adults (ages 14-24). Suicide is a leading cause of death in this population, and current clinical approaches often fail to accurately predict or prevent suicidal behavior. This study seeks to identify objective neurobiological markers associated with suicide risk and treatment response. Participants will be divided into three groups: (1) high-risk individuals recently hospitalized following a suicide attempt, (2) medium-risk individuals with chronic suicidal ideation but no attempts, and (3) low-risk healthy controls. All participants will undergo advanced neuroimaging, including magnetoencephalography (MEG) and magnetic resonance imaging (MRI), along with comprehensive psychiatric assessments. The study focuses on brain regions and networks implicated in suicidality, including the anterior cingulate cortex and salience network, as well as neurochemical markers such as glutamate. It also examines electrophysiological activity and functional connectivity patterns associated with suicidal thoughts and behaviors. High-risk participants will receive an evidence-based psychotherapy called the Collaborative Assessment and Management of Suicidality (CAMS). This therapeutic approach emphasizes collaboration between patient and clinician to identify and address the underlying drivers of suicidal thoughts, with a focus on increasing hope and reducing psychological distress. Neuroimaging and clinical assessments will be repeated after completion of CAMS to evaluate treatment-related changes. The study's primary goals are to: * Identify neural and electrophysiological correlates of suicide risk. * Distinguish biological differences between individuals with suicidal ideation and those who have attempted suicide. * Determine how CAMS therapy affe
Primary Outcome
To investigate the effect of changes in Suicide Status Form (SSF) scores (low severity 1-5 high severity) as a result of CAMS therapy on Glx levels.
Interventions
- BEHAVIORAL CAMS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-06-30 |
| Est. Completion | 2031-10-01 |
| Phase | NA |
What is known before NCT07568054 opens enrollment
NCT07568054 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which CAMS is the first listed.
NCT07568054 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07568054 about?
NCT07568054 is a clinical study titled "Neural Correlates of Suicidal Behavior in Youth". This study, titled "Neural Correlates of Suicidal Behavior in Youth: a Pre and Post CAMS Therapy Neuroimaging Study," aims to better understand the brain mechanisms underlying suicidal thoughts and behaviors in adolescents and young adults (ages 14-24). Suicide is a leading cause of death in this po...
What is the current status of trial NCT07568054?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2026-06-30. Estimated completion is 2031-10-01.
What interventions are being tested in trial NCT07568054?
The interventions under investigation include: CAMS (BEHAVIORAL).
Who is sponsoring clinical trial NCT07568054?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07568054's enrollment target sits among peer trials
60 1164th of 2000 higher than 745 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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