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NCT04731363 · ClinicalTrials.gov registry record · NA
Consumption of Oral Artificial Sweeteners on Platelet Aggregation and Polyol Excretion
A NA study of Cardiovascular Risk Factor, sponsored by The Cleveland Clinic.
- Active
- Registry status
- NA
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT04731363 is a NA study of Cardiovascular Risk Factor that is active but no longer recruiting, run by The Cleveland Clinic. The registered enrollment target is 50 participants, below the 3,066-participant average among 31 other Cardiovascular Risk Factor trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04731363, a NA study of Cardiovascular Risk Factor, is active but no longer recruiting, sponsored by The Cleveland Clinic.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
The principal goal for the study is to examine whether ingestion of a beverage containing artificial sweeteners alters in vitro platelet aggregation. Because of the increasing number of cardiometabolic diseases, such as diabetes mellitus, in the population, the use of artificial sweeteners to replace free sugars has been gaining popularity. Two popular artificial sweeteners are erythritol and xylitol. Erythritol and xylitol are both naturally occurring polyols found in fruits and vegetables. They are potent artificial sweeteners with a higher sweetening intensity and lower calorie content than table sugar. Previous research has shown that the higher levels of sugar alcohols, like those used as artificial sweeteners, in the blood are related to a higher risk of cardiovascular complications, like heart attacks and strokes, and death. This may be because higher levels of sugar alcohols in one's blood may increase the activity of platelets, which would then increase the risk of heart attack and stroke. The investigators therefore want to find if consuming a single beverage that contains an artificial sweetener can raise the levels of sugar alcohols in the blood and if it can alter platelet function or aggregation.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT xylitol, 30g
- DIETARY_SUPPLEMENT erythritol, 30g
- DIETARY_SUPPLEMENT xylitol, 5g
- DIETARY_SUPPLEMENT glucose, 30g
Study Locations (1)
Ohio
- Cleveland Clinic - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2021-03-10 |
| Est. Completion | 2025-12 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04731363
The ClinicalTrials.gov registry entry for NCT04731363 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 3,066-participant average among 31 other Cardiovascular Risk Factor trials with a reported enrollment target (98% lower). The listed sponsor is The Cleveland Clinic, which has 688 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Cardiovascular Risk Factor appearing as the primary indexed condition, and to 4 interventions - of which xylitol, 30g is the first listed.
NCT04731363 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.
Frequently Asked Questions
What is clinical trial NCT04731363 about?
NCT04731363 is a clinical study titled "Consumption of Oral Artificial Sweeteners on Platelet Aggregation and Polyol Excretion". The principal goal for the study is to examine whether ingestion of a beverage containing artificial sweeteners alters in vitro platelet aggregation. Because of the increasing number of cardiometabolic diseases, such as diabetes mellitus, in the population, the use of artificial sweeteners to repla...
What is the current status of trial NCT04731363?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 50 participants. The study started on 2021-03-10. Estimated completion is 2025-12.
What conditions does trial NCT04731363 study?
This clinical trial studies the following conditions: Cardiovascular Risk Factor.
What interventions are being tested in trial NCT04731363?
The interventions under investigation include: xylitol, 30g (DIETARY_SUPPLEMENT), erythritol, 30g (DIETARY_SUPPLEMENT), xylitol, 5g (DIETARY_SUPPLEMENT), glucose, 30g (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT04731363?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04731363 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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