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ClinicalTrials.gov 120 recruiting now official registry

Multiple Sclerosis clinical trials

120 of 317 indexed Multiple Sclerosis trials are currently recruiting.

317 US clinical trials · 120 currently recruiting

Multiple Sclerosis is the subject of 317 registered US clinical trials on ClinicalTrials.gov, 120 of them currently open to new participants. 41 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Biogen, running 13 of these trials.

The research picture

Multiple Sclerosis has 317 registered US clinical trials, 120 of them open to new participants right now, about 38% of the total.

120
recruiting participants now
38%
of trials open to enrollment
41
in Phase 3–4 (later-stage)
13
top sponsor: Biogen
Phase 141Phase 233Phase 324Phase 417

Active & Recent Trials

317 total, page 1 of 7

RECRUITING 50,000 participants

NARCOMS Registry: A Multiple Sclerosis Registry

University of Texas Southwestern Medical Center

NCT01018537

RECRUITING 20,000 participants

IConquerMS™ - a Patient-Powered Research Network for Multiple Sclerosis

Accelerated Cure Project for Multiple Sclerosis

NCT02486562

RECRUITING 10,000 participants

Longitudinal Cognitive Assessment by BoCA

Alzheimer's Light

NCT04114994

RECRUITING 7,500 participants

Prospective Investigation of Multiple Sclerosis in the Three Rivers Region

University of Pittsburgh

NCT02994121

RECRUITING NA 5,000 participants

Clinical Applications of Advanced Ophthalmic Imaging

University of Miami

NCT03135327

RECRUITING 5,000 participants

Genes and Environment in Multiple Sclerosis

Columbia University

NCT01353547

RECRUITING 3,750 participants

Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00001248

RECRUITING 2,400 participants

Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00794352

RECRUITING 2,000 participants

Multiple Sclerosis Implementation Network (Registry)

The University of Texas Health Science Center, Houston

NCT07415824

RECRUITING 2,000 participants

Retinal Imaging in Neurodegenerative Disease

Duke University

NCT03233646

RECRUITING NA 2,000 participants

Confirmatory Trial for Alleviating Fatigue in Multiple Sclerosis

Accelerated Cure Project for Multiple Sclerosis

NCT06441617

RECRUITING Phase 3 1,600 participants

Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis

Sanofi

NCT06141473

RECRUITING 1,182 participants

A Study on the Safety of Ozanimod Exposure in Pregnant Women and Their Offspring

Bristol-Myers Squibb

NCT05170126

RECRUITING 1,178 participants

A Study to Learn More About The Safety of Diroximel Fumarate (VUMERITY®) in Participants Who Took it During Pregnancy And About the Health of Their Babies

Biogen

NCT05688436

RECRUITING 1,000 participants

Identifying and Characterizing Preclinical MS

Yale University

NCT05787795

RECRUITING 1,000 participants

Complementary and Alternative Care in Multiple Sclerosis

Bastyr University

NCT01703429

RECRUITING 1,000 participants

MS-ResearchBiomarkerS

Cedars-Sinai Medical Center

NCT05204459

RECRUITING 908 participants

Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)

Biogen

NCT05658497

RECRUITING Phase 3 900 participants

Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis

Sanofi

NCT06141486

RECRUITING 867 participants

Post-Authorization Safety Study for Assessment of Pregnancy Outcomes in Patients Treated With Mayzent

Novartis Pharmaceuticals

NCT04933552

RECRUITING 800 participants

Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

Beth Israel Deaconess Medical Center

NCT04603196

RECRUITING 728 participants

A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)

TG Therapeutics

NCT06433765

RECRUITING 725 participants

Kesimpta (Ofatumumab) Pregnancy Registry

Novartis Pharmaceuticals

NCT05634967

RECRUITING 500 participants

A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

TG Therapeutics

NCT06433752

RECRUITING NA 400 participants

Autoimmune Intervention Mastery Course Study

Terry L. Wahls

NCT05057676

RECRUITING 386 participants

Care in Multiple Sclerosis (MS)

NYU Langone Health

NCT07011914

RECRUITING Phase 1 300 participants

Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer

National Cancer Institute (NCI)

NCT03816345

RECRUITING 300 participants

"Selfie" Videos: A Novel, Patient-centered, Comprehensive Approach to Measuring Function in MS

University of California, San Francisco

NCT07222618

RECRUITING 300 participants

A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease

TScan Therapeutics

NCT06587828

RECRUITING NA 280 participants

Internet-Delivered Lifestyle Physical Activity Intervention for Cognitive Processing Speed in Multiple Sclerosis

University of Illinois at Chicago

NCT04518657

RECRUITING Phase 1 250 participants

Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT03109288

RECRUITING Phase 1 250 participants

PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases

Brigham and Women's Hospital

NCT02649985

RECRUITING 250 participants

Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA)

University of California, San Francisco

NCT06940323

RECRUITING 250 participants

Pathological Basis of MRI Signal Changes in Multiple Sclerosis

National Institute of Neurological Disorders and Stroke (NINDS)

NCT02659956

RECRUITING Phase 2 200 participants

A Study of LY3541860 in Adult Participants With Relapsing Multiple Sclerosis

Eli Lilly and Company

NCT06220669

RECRUITING NA 200 participants

Remote Therapeutic Monitoring Exercise Tracking

Shirley Ryan AbilityLab

NCT06306768

RECRUITING Phase 2 182 participants

A Study to Assess Bioequivalence of Two Subcutaneous (SC) Formulations of Ocrelizumab in Participants With Multiple Sclerosis (MS)

Hoffmann-La Roche

NCT07074886

RECRUITING Phase 2 180 participants

A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years

ModernaTX

NCT06735248

RECRUITING Phase 2 170 participants

Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosis (MS)

NYU Langone Health

NCT06901687

RECRUITING Phase 2 166 participants

Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype

Tiffany J. Braley, MD, MS

NCT05269628

RECRUITING 160 participants

AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis

University of Alabama at Birmingham

NCT04721717

RECRUITING Phase 3 160 participants

Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis

Sanofi

NCT07325292

RECRUITING NA 150 participants

High-Intensity, Dynamic-stability Gait Training in People With Multiple Sclerosis

Marquette University

NCT05735691

RECRUITING NA 147 participants

Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases

Mayo Clinic

NCT06788886

RECRUITING NA 146 participants

Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis

University of Illinois at Chicago

NCT05051618

RECRUITING NA 138 participants

Incremental Vestibulo-ocular Reflex Adaptation as a Novel Treatment for Dizziness in People With Multiple Sclerosis

Emory University

NCT06495138

RECRUITING Phase 1 129 participants

A Study to Investigate the Safety, Tolerability, and Processing by the Body of Intravenous and Subcutaneous RO7121932 Administration in Participants With Multiple Sclerosis

Hoffmann-La Roche

NCT05704361

RECRUITING NA 126 participants

Prepare the Mind: Can Coaching in Goal-directed Behaviour Increase the Success of Cognitive Rehabilitation in People With MS?

Universiteit Leiden

NCT07225868

RECRUITING NA 125 participants

HOBSCOTCH-MS-Efficacy Trial

Dartmouth-Hitchcock Medical Center

NCT06951919

RECRUITING Phase 4 123 participants

Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis

National Institute of Allergy and Infectious Diseases (NIAID)

NCT05285891

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Phase Distribution

PhaseTrial count
Phase 1 41
Phase 2 33
Phase 3 24
Phase 4 17

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Multiple Sclerosis Trial Landscape

317 indexed Multiple Sclerosis studies · 120 recruiting (38%).

Phase mix: 41 late (III/IV) vs 74 early (I/II).

Top sponsor: Biogen (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Multiple Sclerosis?

PlainTrial tracks 317 US clinical trials for Multiple Sclerosis, of which 120 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Multiple Sclerosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.