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Multiple Sclerosis clinical trials
120 of 317 indexed Multiple Sclerosis trials are currently recruiting.
317 US clinical trials · 120 currently recruiting
Multiple Sclerosis is the subject of 317 registered US clinical trials on ClinicalTrials.gov, 120 of them currently open to new participants. 41 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Biogen, running 13 of these trials.
The research picture
Multiple Sclerosis has 317 registered US clinical trials, 120 of them open to new participants right now, about 38% of the total.
- 120
- recruiting participants now
- 38%
- of trials open to enrollment
- 41
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Biogen
Active & Recent Trials
317 total, page 1 of 7
NARCOMS Registry: A Multiple Sclerosis Registry
University of Texas Southwestern Medical Center
NCT01018537
IConquerMS™ - a Patient-Powered Research Network for Multiple Sclerosis
Accelerated Cure Project for Multiple Sclerosis
NCT02486562
Longitudinal Cognitive Assessment by BoCA
Alzheimer's Light
NCT04114994
Prospective Investigation of Multiple Sclerosis in the Three Rivers Region
University of Pittsburgh
NCT02994121
Clinical Applications of Advanced Ophthalmic Imaging
University of Miami
NCT03135327
Genes and Environment in Multiple Sclerosis
Columbia University
NCT01353547
Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00001248
Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00794352
Multiple Sclerosis Implementation Network (Registry)
The University of Texas Health Science Center, Houston
NCT07415824
Retinal Imaging in Neurodegenerative Disease
Duke University
NCT03233646
Confirmatory Trial for Alleviating Fatigue in Multiple Sclerosis
Accelerated Cure Project for Multiple Sclerosis
NCT06441617
Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis
Sanofi
NCT06141473
A Study on the Safety of Ozanimod Exposure in Pregnant Women and Their Offspring
Bristol-Myers Squibb
NCT05170126
A Study to Learn More About The Safety of Diroximel Fumarate (VUMERITY®) in Participants Who Took it During Pregnancy And About the Health of Their Babies
Biogen
NCT05688436
Identifying and Characterizing Preclinical MS
Yale University
NCT05787795
Complementary and Alternative Care in Multiple Sclerosis
Bastyr University
NCT01703429
MS-ResearchBiomarkerS
Cedars-Sinai Medical Center
NCT05204459
Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
Biogen
NCT05658497
Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis
Sanofi
NCT06141486
Post-Authorization Safety Study for Assessment of Pregnancy Outcomes in Patients Treated With Mayzent
Novartis Pharmaceuticals
NCT04933552
Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis
Beth Israel Deaconess Medical Center
NCT04603196
A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)
TG Therapeutics
NCT06433765
Kesimpta (Ofatumumab) Pregnancy Registry
Novartis Pharmaceuticals
NCT05634967
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
TG Therapeutics
NCT06433752
Autoimmune Intervention Mastery Course Study
Terry L. Wahls
NCT05057676
Care in Multiple Sclerosis (MS)
NYU Langone Health
NCT07011914
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer
National Cancer Institute (NCI)
NCT03816345
"Selfie" Videos: A Novel, Patient-centered, Comprehensive Approach to Measuring Function in MS
University of California, San Francisco
NCT07222618
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
TScan Therapeutics
NCT06587828
Internet-Delivered Lifestyle Physical Activity Intervention for Cognitive Processing Speed in Multiple Sclerosis
University of Illinois at Chicago
NCT04518657
Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03109288
PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases
Brigham and Women's Hospital
NCT02649985
Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA)
University of California, San Francisco
NCT06940323
Pathological Basis of MRI Signal Changes in Multiple Sclerosis
National Institute of Neurological Disorders and Stroke (NINDS)
NCT02659956
A Study of LY3541860 in Adult Participants With Relapsing Multiple Sclerosis
Eli Lilly and Company
NCT06220669
Remote Therapeutic Monitoring Exercise Tracking
Shirley Ryan AbilityLab
NCT06306768
A Study to Assess Bioequivalence of Two Subcutaneous (SC) Formulations of Ocrelizumab in Participants With Multiple Sclerosis (MS)
Hoffmann-La Roche
NCT07074886
A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years
ModernaTX
NCT06735248
Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosis (MS)
NYU Langone Health
NCT06901687
Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype
Tiffany J. Braley, MD, MS
NCT05269628
AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis
University of Alabama at Birmingham
NCT04721717
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
Sanofi
NCT07325292
High-Intensity, Dynamic-stability Gait Training in People With Multiple Sclerosis
Marquette University
NCT05735691
Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases
Mayo Clinic
NCT06788886
Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis
University of Illinois at Chicago
NCT05051618
Incremental Vestibulo-ocular Reflex Adaptation as a Novel Treatment for Dizziness in People With Multiple Sclerosis
Emory University
NCT06495138
A Study to Investigate the Safety, Tolerability, and Processing by the Body of Intravenous and Subcutaneous RO7121932 Administration in Participants With Multiple Sclerosis
Hoffmann-La Roche
NCT05704361
Prepare the Mind: Can Coaching in Goal-directed Behaviour Increase the Success of Cognitive Rehabilitation in People With MS?
Universiteit Leiden
NCT07225868
HOBSCOTCH-MS-Efficacy Trial
Dartmouth-Hitchcock Medical Center
NCT06951919
Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05285891
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 33 |
| Phase 3 | 24 |
| Phase 4 | 17 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Multiple Sclerosis Trial Landscape
317 indexed Multiple Sclerosis studies · 120 recruiting (38%).
Phase mix: 41 late (III/IV) vs 74 early (I/II).
Top sponsor: Biogen (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Multiple Sclerosis?
PlainTrial tracks 317 US clinical trials for Multiple Sclerosis, of which 120 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Multiple Sclerosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.