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NCT04748861 · ClinicalTrials.gov registry record · NA
CYCLE-AD (CYcling to Cease or Limit the Effects of Alzheimer's Disease)
A NA study of High Intensity Exercise and Normal Cognition, sponsored by The Cleveland Clinic.
- Active
- Registry status
- NA
- Development phase
- 150
- Enrollment target
- 1
- Study location
NCT04748861: Active NA study of High Intensity Exercise and Normal Cognition, sponsored by The Cleveland Clinic.
NCT04748861 is a NA study of High Intensity Exercise and Normal Cognition that is active but no longer recruiting, run by The Cleveland Clinic. The registered enrollment target is 150 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04748861, a NA study of High Intensity Exercise and Normal Cognition, is active but no longer recruiting, sponsored by The Cleveland Clinic.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
The overall goal of the CYCLE-AD trial is to determine the role of long-term, high intensity exercise in slowing or delaying the onset of cognitive and AD-related brain changes in e4 carriers. Successful translation and demonstration of the effectiveness of a scalable home-based exercise intervention capable of slowing or delaying disease onset will transform AD treatment, improve patient outcomes and quality of life, and reduce health care costs.
Primary Outcome
Determine the effects of an IC intervention on cognitive functioning
Conditions Studied
Interventions
- OTHER Indoor Cycling (IC)
Study Locations (1)
Ohio
- Cleveland Clinic - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2021-10-20 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
What the registry record for NCT04748861 still lists
NCT04748861 is an interventional study that assigns participants to a tested intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (89% lower).
The record links to 3 conditions, with High Intensity Exercise appearing as the primary indexed condition, and to 1 intervention - of which Indoor Cycling (IC) is the first listed.
NCT04748861 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT04748861 about?
NCT04748861 is a clinical study titled "CYCLE-AD (CYcling to Cease or Limit the Effects of Alzheimer's Disease)". The overall goal of the CYCLE-AD trial is to determine the role of long-term, high intensity exercise in slowing or delaying the onset of cognitive and AD-related brain changes in e4 carriers. Successful translation and demonstration of the effectiveness of a scalable home-based exercise interventio...
What is the current status of trial NCT04748861?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 150 participants. The study started on 2021-10-20. Estimated completion is 2026-12-31.
What conditions does trial NCT04748861 study?
This clinical trial studies the following conditions: High Intensity Exercise, Normal Cognition, Exercise Intervention.
What interventions are being tested in trial NCT04748861?
The interventions under investigation include: Indoor Cycling (IC) (OTHER).
Who is sponsoring clinical trial NCT04748861?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04748861 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04748861's enrollment target sits among peer trials
150 661st of 2000 higher than 1,299 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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