The Cleveland Clinic

688 total trials 99 currently recruiting 437 completed

The Cleveland Clinic sponsors 688 registered US clinical trials on ClinicalTrials.gov, 99 of them currently recruiting, and 437 completed. 81 of these trials are in Phase 3-4 (later-stage) and 76 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atrial Fibrillation, with 9 trials.

Trial Pipeline

688 total, page 2 of 14

RECRUITING

Evaluation of Outcomes of the Triathlon Hinge Knee (THK) System

NCT06379321

RECRUITING NA

Engaging Patients in Prenatal Genetic Testing Decisions as a Pathway to Improve Obstetric Outcomes

NCT06382636

RECRUITING

Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor

NCT06293638

RECRUITING NA

Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes

NCT06298721

RECRUITING NA

Efficacy of A Novel RinSe Device to Reduce Oral Bacteria in Intubated IntEnsive CaRe Patients: a Pilot Study

NCT06193512

RECRUITING Early Phase 1

Rebuilding Inter-limb Transfer in Cervical SCI

NCT06440538

RECRUITING

Precise and Objective Identification of Bertolotti Syndrome Using Novel Kinematic Biomarkers

NCT06225583

RECRUITING NA

Preoperative Pelvic Floor Physical Therapy to Minimize Stress Urinary Incontinence After Holmium Laser Enucleation of the Prostate

NCT06179654

RECRUITING NA

Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue

NCT06789809

RECRUITING NA

Efficacy of Low-intensity Shockwave vs Radial Wave for Treatment of Erectile Dysfunction and Pelvic Pain

NCT05868668

RECRUITING

Phenotypic Classification of FMR With CMR

NCT05965258

RECRUITING NA

Randomized Controlled Trial of Miniaturized Percutaneous Nephrolithotomy With Vacuum-Assisted Access Sheaths Versus Conventional Sheaths for Treatment of Nephrolithiasis

NCT05993546

RECRUITING NA

Home Versus Office Removal of Percutaneous Nerve Evaluation (PNE) Lead

NCT05799313

RECRUITING NA

Molecular Mechanism of Exercise in Cirrhosis

NCT05982769

RECRUITING NA

Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients

NCT05725928

RECRUITING NA

Intraoperative Electrical Stimulation to Improve Nerve Grafting Outcome

NCT06335719

RECRUITING NA

Intracardiac Echocardiography Guided Watchman Device Implant

NCT06007872

RECRUITING

CV Imaging of Metabolic Interventions

NCT05650307

RECRUITING

Development of CIRC Technologies

NCT05654272

RECRUITING Early Phase 1

HA35 Moderate Alcoholic Hepatitis (AH) Study

NCT05018481

RECRUITING

Global Cardio Oncology Registry

NCT05598879

RECRUITING Early Phase 1

HA35 Acute Alcohol Study

NCT05025865

RECRUITING NA

HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis

NCT05166499

RECRUITING

Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)

NCT04869813

RECRUITING NA

Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19

NCT04858412

RECRUITING NA

Structural Modification In Supraglottic Airway Device

NCT04498598

RECRUITING NA

MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES)

NCT04578392

RECRUITING Phase 4

Dextenza in the Post-op Management of Vitreoretinal Surgeries

NCT04371445

RECRUITING

Normal Donor Blood Draws for Platelet Studies and Biomarker Evaluation (ND-PLT)

NCT05628974

RECRUITING

Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy

NCT04310241

RECRUITING

Vascular Lab Resource (VLR) Biorepository

NCT05628948

RECRUITING Phase 4

Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study

NCT04191681

RECRUITING

Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and Patients With Alcoholic Hepatitis

NCT04088370

RECRUITING NA

Late Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy

NCT04096014

RECRUITING

A Cardiac Disease Quality of Life Study

NCT04080492

RECRUITING

Comparative Imaging Assessment of Valvular Heart Disease

NCT04126018

RECRUITING NA

rTMS Plus CCFES-mediated Functional Task Practice for Severe Stroke

NCT03870672

RECRUITING

Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis

NCT03225677

RECRUITING

Comparison of ALD, NASH, and Healthy Control Patients

NCT03224949

RECRUITING NA

Can Prophylactic Foraminotomy Prevent C5 Palsy

NCT03023696

RECRUITING

Corneal Elastography and Patient Specific Modeling

NCT03030755

RECRUITING

Ethanol Induces Skeletal Muscle Autophagy

NCT03209791

RECRUITING NA

Gut Flora Metabolite Reduction After Dietary Intervention (GRADY)

NCT02016430

RECRUITING

DISCOVER Study: Microscope-integrated Intraoperative OCT Study

NCT02423213

RECRUITING NA

Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis

NCT03208868

RECRUITING

Analysis of Anterior Chamber Inflammation by Optical Coherence Tomography

NCT01746537

RECRUITING

Genetics of Uveitis

NCT02357238

RECRUITING

Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic

NCT00921986

RECRUITING

Mechanisms of Malnutrition in Cirrhosis With Portosystemic Shunting

NCT03121404

ACTIVE NOT RECRUITING NA

Neuromodulation With Percutaneous Electrical Nerve Field Stimulation

NCT07492108

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Phase Distribution

PhaseTrial count
Phase 1 38
Phase 2 38
Phase 3 22
Phase 4 59

What the Pipeline for The Cleveland Clinic Shows

According to the ClinicalTrials.gov registry, The Cleveland Clinic is linked to 688 US clinical trials across every stage of research activity. Of those, 99 studies are currently recruiting, about 14% of the sponsor's indexed portfolio, and 437 are already marked complete, representing roughly 64% of the total.

The phase mix for The Cleveland Clinic reports 81 late-stage studies (Phase 3 and Phase 4 combined) and 76 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for The Cleveland Clinic is Atrial Fibrillation with 9 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.