The Cleveland Clinic
The Cleveland Clinic sponsors 688 registered US clinical trials on ClinicalTrials.gov, 99 of them currently recruiting, and 437 completed. 81 of these trials are in Phase 3-4 (later-stage) and 76 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atrial Fibrillation, with 9 trials.
Trial Pipeline
688 total, page 2 of 14
Evaluation of Outcomes of the Triathlon Hinge Knee (THK) System
NCT06379321
Engaging Patients in Prenatal Genetic Testing Decisions as a Pathway to Improve Obstetric Outcomes
NCT06382636
Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor
NCT06293638
Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes
NCT06298721
Efficacy of A Novel RinSe Device to Reduce Oral Bacteria in Intubated IntEnsive CaRe Patients: a Pilot Study
NCT06193512
Rebuilding Inter-limb Transfer in Cervical SCI
NCT06440538
Precise and Objective Identification of Bertolotti Syndrome Using Novel Kinematic Biomarkers
NCT06225583
Preoperative Pelvic Floor Physical Therapy to Minimize Stress Urinary Incontinence After Holmium Laser Enucleation of the Prostate
NCT06179654
Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue
NCT06789809
Efficacy of Low-intensity Shockwave vs Radial Wave for Treatment of Erectile Dysfunction and Pelvic Pain
NCT05868668
Phenotypic Classification of FMR With CMR
NCT05965258
Randomized Controlled Trial of Miniaturized Percutaneous Nephrolithotomy With Vacuum-Assisted Access Sheaths Versus Conventional Sheaths for Treatment of Nephrolithiasis
NCT05993546
Home Versus Office Removal of Percutaneous Nerve Evaluation (PNE) Lead
NCT05799313
Molecular Mechanism of Exercise in Cirrhosis
NCT05982769
Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients
NCT05725928
Intraoperative Electrical Stimulation to Improve Nerve Grafting Outcome
NCT06335719
Intracardiac Echocardiography Guided Watchman Device Implant
NCT06007872
CV Imaging of Metabolic Interventions
NCT05650307
Development of CIRC Technologies
NCT05654272
HA35 Moderate Alcoholic Hepatitis (AH) Study
NCT05018481
Global Cardio Oncology Registry
NCT05598879
HA35 Acute Alcohol Study
NCT05025865
HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis
NCT05166499
Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)
NCT04869813
Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19
NCT04858412
Structural Modification In Supraglottic Airway Device
NCT04498598
MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES)
NCT04578392
Dextenza in the Post-op Management of Vitreoretinal Surgeries
NCT04371445
Normal Donor Blood Draws for Platelet Studies and Biomarker Evaluation (ND-PLT)
NCT05628974
Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy
NCT04310241
Vascular Lab Resource (VLR) Biorepository
NCT05628948
Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study
NCT04191681
Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and Patients With Alcoholic Hepatitis
NCT04088370
Late Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy
NCT04096014
A Cardiac Disease Quality of Life Study
NCT04080492
Comparative Imaging Assessment of Valvular Heart Disease
NCT04126018
rTMS Plus CCFES-mediated Functional Task Practice for Severe Stroke
NCT03870672
Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis
NCT03225677
Comparison of ALD, NASH, and Healthy Control Patients
NCT03224949
Can Prophylactic Foraminotomy Prevent C5 Palsy
NCT03023696
Corneal Elastography and Patient Specific Modeling
NCT03030755
Ethanol Induces Skeletal Muscle Autophagy
NCT03209791
Gut Flora Metabolite Reduction After Dietary Intervention (GRADY)
NCT02016430
DISCOVER Study: Microscope-integrated Intraoperative OCT Study
NCT02423213
Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis
NCT03208868
Analysis of Anterior Chamber Inflammation by Optical Coherence Tomography
NCT01746537
Genetics of Uveitis
NCT02357238
Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic
NCT00921986
Mechanisms of Malnutrition in Cirrhosis With Portosystemic Shunting
NCT03121404
Neuromodulation With Percutaneous Electrical Nerve Field Stimulation
NCT07492108
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 38 |
| Phase 2 | 38 |
| Phase 3 | 22 |
| Phase 4 | 59 |
Therapeutic Areas
What the Pipeline for The Cleveland Clinic Shows
According to the ClinicalTrials.gov registry, The Cleveland Clinic is linked to 688 US clinical trials across every stage of research activity. Of those, 99 studies are currently recruiting, about 14% of the sponsor's indexed portfolio, and 437 are already marked complete, representing roughly 64% of the total.
The phase mix for The Cleveland Clinic reports 81 late-stage studies (Phase 3 and Phase 4 combined) and 76 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for The Cleveland Clinic is Atrial Fibrillation with 9 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.