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NCT01759186 · ClinicalTrials.gov registry record
Airway Redox and Gender Determinants in Severe Asthma
A clinical trial of Asthma, sponsored by The Cleveland Clinic.
- Active
- Registry status
- 300
- Enrollment target
- 4
- Study locations
NCT01759186: Active study of Asthma, sponsored by The Cleveland Clinic.
NCT01759186 is a study of Asthma that is active but no longer recruiting, run by The Cleveland Clinic. The registered enrollment target is 300 participants, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (81% lower). The trial reports 4 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01759186, a study of Asthma, is active but no longer recruiting, sponsored by The Cleveland Clinic.
- ACTIVE NOT RECRUITING
- Registry status
- 300 participants
- Enrollment target
- 4
- Study locations
Study Summary
The investigators will study the biologic and chemical differences that cause the greater incidence, and severity of asthma in women as compared to men. Severe asthma affects boys more than girls, while severe asthma in adults is predominantly a disease of women. The investigators aim to identify the processes that occur in the body that are behind the onset of severe asthma in young women during the teenage years, and the resolution of severe asthma in boys. To further evaluate gender influences on asthma, asthmatic women at different stages of their menstrual cycle (period) will be also studied. The investigators aim to use biomarkers to develop testing procedures that will identify different types or characteristics of asthma in men and women; and to follow patients over time to uncover relevant clinical outcomes of biomarkers. The investigators anticipate that they will 1) develop clinically relevant tests to identify unique types or characteristics of asthma and severe asthma; 2) determine outcomes over time of biochemically-defined types of asthma; and 3) identify the reasons for why adult women are affected more than men with severe asthma.
Primary Outcome
To determine if asthma severity is worsened in females with changes in estradiol that occur during puberty as measured by asthma control tests and lung functions
Conditions Studied
Study Locations (4)
Ohio
- Rainbow Babies and Children's Hospital - Cleveland
- Cleveland Clinic - Cleveland
Virginia
- University of Virginia - Charlottesville
- Virginia Commonwealth University - Richmond
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2012-12 |
| Est. Completion | 2027-08 |
What the registry record for NCT01759186 still lists
NCT01759186 is an observational study that tracks outcomes without assigning an intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (81% lower).
The record links to 1 condition, with Asthma appearing as the primary indexed condition, and to 0 interventions.
NCT01759186 reports a single indexed study location in Ohio, Virginia.
Frequently Asked Questions
What is clinical trial NCT01759186 about?
NCT01759186 is a clinical study titled "Airway Redox and Gender Determinants in Severe Asthma". The investigators will study the biologic and chemical differences that cause the greater incidence, and severity of asthma in women as compared to men. Severe asthma affects boys more than girls, while severe asthma in adults is predominantly a disease of women. The investigators aim to identify th...
What is the current status of trial NCT01759186?
This trial is currently active not recruiting. The enrollment target is 300 participants. The study started on 2012-12. Estimated completion is 2027-08.
What conditions does trial NCT01759186 study?
This clinical trial studies the following conditions: Asthma.
Who is sponsoring clinical trial NCT01759186?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01759186 being conducted?
This trial has 4 study locations across Ohio, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Asthma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01759186's enrollment target sits among peer trials
300 125th of 374 higher than 247 of 374 other Asthma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Asthma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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