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Heart Failure: full-pipeline trial registry
164 of 399 indexed Heart Failure trials are currently recruiting.
Corpus placement: #13 of 28,707 conditions by registered trial count.
399 US clinical trials · 164 currently recruiting · #13 of 28,707 conditions by registered trial count
Heart Failure: 399 US clinical trials tracked, 164 recruiting.
Heart Failure is the subject of 399 registered US clinical trials on ClinicalTrials.gov, 164 of them currently open to new participants. 47 are in Phase 3-4 (later-stage) and 63 in Phase 1-2 (earlier-stage). The most active sponsor is Abbott Medical Devices, running 15 of these trials.
Enrollment posture brief
Registry condition heart-failure
OPEN 164 | RECR 41% | LATE 47 | EARLY 63 | RANK #13 | SPON 15
Volume-matched condition peers
Nearest open-share peer: Erectile Dysfunction (41% recruiting · 34 trials)
Heart Failure lists 164 open slots (41% of 399 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Heart Failure on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Heart Failure is recruiting above its size-band peers.
164 of 399 indexed trials (41.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Heart Failure trials is spread across many organizations.
Abbott Medical Devices accounts for 15 of 399 trials (3.8%). 195 distinct sponsors appear on at least one study for this condition label.
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Typical Heart Failure enrolment sits around 128 participants.
Median target enrolment is 128 among the 398 trials that report a genuine target (sentinel values excluded). 177 of those (44.5%) plan for fewer than 100 participants.
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Heart Failure research is mostly interventional.
297 interventional and 102 observational studies make up this index (74.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
399 total, page 1 of 8
Get With The Guidelines-Heart Failure Registry
American Heart Association
NCT02693509
Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System
Yale University
NCT04237701
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
Medtronic
NCT00271180
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
AstraZeneca
NCT06677060
Cardiovascular Health Improvement Project
University of Michigan
NCT02306200
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Boehringer Ingelheim
NCT06424288
A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
Novo Nordisk A/S
NCT05636176
CCM OPEN HF Registry
Impulse Dynamics
NCT07112924
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Colorado Prevention Center
NCT06008197
Cardiovascular Multimodality Imaging Study
Montefiore Medical Center
NCT06610019
PRagmatic Trial Of Messaging to Providers About Treatment of Heart Failure at Inova
Inova Health Care Services
NCT05433220
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Duke University
NCT04278404
Study of the Progression of Chronic Cardiovascular Conditions
Prolaio
NCT07420907
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
Boehringer Ingelheim
NCT06935370
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
Brigham and Women's Hospital
NCT01258231
Tailored Electronic Intervention to Improve Therapy in a Diverse Cohort of Patients With Heart Failure
Emory University
NCT06847438
Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"
NHS Greater Glasgow and Clyde
NCT05919342
Home Hospital for Suddenly Ill Adults
Brigham and Women's Hospital
NCT03524222
A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients with Heart Failure Who Are Intolerant or Not Eligible for Treatment with Steroidal Mineralocorticoid Receptor Antagonists
Colorado Prevention Center
NCT06033950
Real World Effectiveness of the Cordella Pulmonary Artery Sensor System in Patients With Chronic Heart Heart Failure
Endotronix
NCT06783335
Left vs Left Randomized Clinical Trial
Baylor College of Medicine
NCT05650658
HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry
University of Kansas Medical Center
NCT06425848
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
Cytokinetics
NCT06736574
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
Endotronix
NCT05934487
Implantable Cardioverter Defibrillator (ICD Registry)
American College of Cardiology
NCT01999140
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
Peerbridge Health
NCT06699056
A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients with Heart Failure (CONFIRMATION-HF)
Colorado Prevention Center
NCT06024746
UIC Multi-Ethnic DCM Registry
University of Illinois at Chicago
NCT07145138
The HEARTFELT Study
Heartfelt Technologies
NCT06222099
Assessment of CCM in HF With Higher Ejection Fraction
Impulse Dynamics
NCT05064709
Feasibility and Efficacy Study of the CardioPulmonary Management (CPM) System in Patients With Chronic Heart Failure
Analog Device
NCT05650541
Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF)
Weill Medical College of Cornell University
NCT06118983
CardioMEMS HF System Coverage with Evidence Development Study
Abbott Medical Devices
NCT06779552
HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets
Northwestern University
NCT05873634
Early Assessment and Initiation of GuideLine-Directed Evidence-Based Management-HF
The Cleveland Clinic
NCT06849752
Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues
Arunark Kolipaka
NCT01757730
Care Coordination to Assess Improvement in Outcomes in Hospital Readmissions
Aventyn
NCT04905160
Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II
AliveCor
NCT06271577
Development of CIRC Technologies
The Cleveland Clinic
NCT05654272
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
Abbott Medical Devices
NCT06526195
Contrast Echocardiography During Exercise to Assess Pulmonary Blood Volume
Mayo Clinic
NCT06195059
Using Ultromics EchoGo HFpEF Algorithm to Identify and Treat High Heart Failure Risk in Patients With Type 2 Diabetes
University of Texas Southwestern Medical Center
NCT06593314
Care Transitions App for Patients With Multiple Chronic Conditions
Brigham and Women's Hospital
NCT06051058
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
BrioHealth Solutions
NCT06310031
A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation
Novo Nordisk A/S
NCT06200207
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
Pfizer
NCT06991257
Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF
Massachusetts General Hospital
NCT05577819
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure
UConn Health
NCT00762008
Integration of Telemedicine and Home-Based Cardiac Rehabilitation: Feasibility, Efficacy, and Adherence
ROM Technologies
NCT05972070
AN International, Observational, Blinded Study TO Assess THE Performance OF THE Cordio Hearo System
Cordio Medical
NCT06378632
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 28 |
| Phase 2 | 35 |
| Phase 3 | 24 |
| Phase 4 | 23 |
Top Sponsors
Named interventions
Most-linked intervention names on Heart Failure records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Heart Failure trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Heart Failure page
399 registered trials, 164 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 164 Heart Failure trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Abbott Medical Devices sponsors the most Heart Failure trials on record, review their full trial history before evaluating a specific study. See Abbott Medical Devices's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Heart Failure condition card totals 399 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.