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ClinicalTrials.gov 16 recruiting now early-phase tilt

Sarcopenia: early-phase trial registry

16 of 42 indexed Sarcopenia trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #347 of 28,707 conditions by registered trial count.

42 US clinical trials · 16 currently recruiting · #347 of 28,707 conditions by registered trial count

Sarcopenia: 42 US clinical trials tracked, 16 recruiting.

Sarcopenia is the subject of 42 registered US clinical trials on ClinicalTrials.gov, 16 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Tufts University, running 3 of these trials.

Enrollment posture brief

Registry condition sarcopenia

OPEN 16 | RECR 38% | LATE 1 | EARLY 6 | RANK #347 | SPON 3

Nearest open-share peer: Behavior, Health (38% recruiting · 21 trials)

Gestational Diabetes64.3%Essential Tremor57.1%Epithelial Ovarian Cancer42.9%Sarcopenia (this)38%Dry Eye21.4%
Open-enrollment share among volume-matched conditions near Sarcopenia

Sarcopenia lists 16 open slots (38% of 42 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Sarcopenia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Sarcopenia recruits in line with its size-band peers.

    16 of 42 indexed trials (38.1%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Sarcopenia trials is spread across many organizations.

    Tufts University accounts for 3 of 42 trials (7.1%). 32 distinct sponsors appear on at least one study for this condition label.

  3. Most Sarcopenia trials plan to enrol fewer than 100 people.

    Median target enrolment is 60 among the 42 trials that report a genuine target (sentinel values excluded). 30 of those (71.4%) plan for fewer than 100 participants.

  4. Sarcopenia research is mostly interventional.

    31 interventional and 11 observational studies make up this index (73.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 12Phase 24Phase 41

Open and recent trials

42 total, page 1 of 1

RECRUITING 300 participants

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

Wake Forest University Health Sciences

NCT03998202

RECRUITING 250 participants

Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty

University of California, Los Angeles

NCT04717869

RECRUITING NA 250 participants

Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)

Florida Institute for Human and Machine Cognition

NCT06507189

RECRUITING NA 144 participants

Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans

VA Office of Research and Development

NCT04691986

RECRUITING 100 participants

Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

Bettina Mittendorfer

NCT07083557

RECRUITING 100 participants

Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery

University of North Carolina, Chapel Hill

NCT06988176

RECRUITING NA 100 participants

Adverse Outcomes and Mortality in Liver Transplant

Mayo Clinic

NCT05477277

RECRUITING NA 80 participants

Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD

The Cleveland Clinic

NCT07059637

RECRUITING 70 participants

Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)

The Cleveland Clinic

NCT04869813

RECRUITING NA 66 participants

The Foods & Oil to Repair, Correct and Enhance Strength (FORCES) Study

Ohio State University

NCT06361511

RECRUITING NA 60 participants

The Influence of Movement Velocity Biofeedback on Muscle Activation and Self Perception in Older Adults With Sarcopenia

Creighton University

NCT06853275

RECRUITING NA 50 participants

Project Gnosis: the Neurophysical and Psychosocial Health Outcomes of Tai Chi for Older Adults with Cognitive Concerns or Mild Cognitive Impairment

Ohio University

NCT06828926

RECRUITING NA 36 participants

Strength Training and Resveratrol

Texas Tech University

NCT06585865

RECRUITING NA 24 participants

C-Protein in Fatigue and Aging

University of Oregon

NCT05926219

RECRUITING NA 20 participants

Exercise and Nutritional Prehabilitation for Head and Neck Cancer Patients

University of California, Davis

NCT06722508

RECRUITING NA 12 participants

Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults

University of Missouri-Columbia

NCT06689618

ACTIVE NOT RECRUITING NA 200 participants

Muscle Insulin Resistance in Aging (Mirage)

AdventHealth Translational Research Institute

NCT02230839

ACTIVE NOT RECRUITING 75 participants

Electrical Stimulation of Human Myocytes in Microgravity

AdventHealth Translational Research Institute

NCT03665051

ACTIVE NOT RECRUITING NA 60 participants

Assessing The Effects of Exercise, Protein, and Electric Stimulation On Intensive Care Unit Patients Outcomes

University of Maryland, Baltimore

NCT02509520

ACTIVE NOT RECRUITING Phase 4 20 participants

Muscle Impact of Treating Osteoporosis

Nami Safai Haeri

NCT05666310

COMPLETED NA 200 participants

Improving Frailty With a Rigorous Ambulation Intervention in Lung Transplant Patients

The Cleveland Clinic

NCT03636412

COMPLETED NA 150 participants

Efficacy of Nutritional Supplementation on Physical-activity Mediated Changes in Physical Functioning Older Adults at Risk for Mobility Disability (The VIVE2 Study)

Tufts University

NCT01542892

COMPLETED 112 participants

Improving Muscle Assessment in Older Adults - The "Can We Build a Better Mouse Trap?" Study

University of Wisconsin, Madison

NCT02295241

COMPLETED Phase 2 108 participants

HORMA: Hormonal Regulators of Muscle and Metabolism in Aging

National Institute on Aging (NIA)

NCT00183040

COMPLETED 96 participants

Evaluation of the Reproducibility of Jumping Mechanography

University of Wisconsin, Madison

NCT01164670

COMPLETED NA 77 participants

Fish Oil and Muscle Function

Washington University School of Medicine

NCT01308957

COMPLETED NA 70 participants

The Urinary Incontinence Treatment Study

Wake Forest University Health Sciences

NCT03057834

COMPLETED 63 participants

Skeletal Muscle Apoptosis and Physical Performance; Oxidative RNA/DNA Damage and Repair in Aged Human Muscle

University of Florida

NCT01644279

COMPLETED NA 56 participants

Culinary Medicine to Enhance Protein Intake on Muscle Quality in Older Adults

Texas Tech University

NCT05593978

COMPLETED NA 46 participants

The Effect of the DASH Diet Containing Meat on Muscle and Metabolic Health in Older Adults

South Dakota State University

NCT04127240

COMPLETED NA 41 participants

Clinical Trial of Astaxanthin Formulation With Exercise in Sarcopenia Elderly

Astavita

NCT03368872

COMPLETED Phase 2 40 participants

Evaluation of Efficacy, Tolerability, and Pharmacokinetics of MYMD1 for Chronic Inflammation and Sarcopenia/Frailty

TNF Pharmaceuticals

NCT05283486

COMPLETED NA 40 participants

IMPACT: Inactivity Monitoring and Physical Activity Controlled Trial

The University of Texas Medical Branch, Galveston

NCT01869348

COMPLETED Phase 2 34 participants

Biological Effects of Weight Loss In Older, Obese Women

University of Florida

NCT01032733

COMPLETED 29 participants

Role of the Gut Microbiome on Lean Mass and Physical Function in Older Adults

Tufts University

NCT02811445

COMPLETED NA 24 participants

A Pilot Study of the Impact of Vitamin D3 on Muscle Performance in Elderly Women

Tufts University

NCT00986596

COMPLETED Phase 1 23 participants

The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity

Sara Espinoza

NCT03119610

COMPLETED NA 20 participants

Effects of Multicomponent Training in Older Adults

Geisinger Clinic

NCT06094413

COMPLETED NA 15 participants

The Influence of Daily Grapes Intake on Sarcopenia in Postmenopausal Women

University of California, Davis

NCT05863507

COMPLETED Phase 1 13 participants

Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals

Indiana University

NCT03595774

COMPLETED 12 participants

PET/CT of Skeletal Muscle Amino Acid Kinetics

University of California, San Francisco

NCT01698424

COMPLETED Phase 2 11 participants

Trial of Oral Glutamine on Mitochondrial Function in CKD

University of Washington

NCT02838979

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 4
Phase 4 1

Named interventions

Most-linked intervention names on Sarcopenia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Placebo Dietary supplement
3 trials
Placebo Other
2 trials
Multicomponent Training Intervention Behavioral
1 trials
Ambulation Other
1 trials
Second Intervention (14 days) Dietary supplement
1 trials
Washout (3 weeks) Other
1 trials
First Intervention (14 days) Dietary supplement
1 trials
DASH diet containing daily intakes of red meat Other
1 trials

US sites by state

Facility locations filed on Sarcopenia trials. A trial with sites in several states counts in each.

Florida 6 trials
Ohio 5 trials
Missouri 5 trials
Texas 4 trials
Massachusetts 4 trials
California 4 trials
Wisconsin 2 trials
Washington 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Sarcopenia page

42 registered trials, 16 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Sarcopenia condition card totals 42 registered trials; most-linked intervention Placebo; top US site state Florida. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.