Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04334668 · ClinicalTrials.gov registry record · NA
Oral Sodium to Preserve Renal EfficiencY in Acute Heart Failure
A NA study of Volume Overload, sponsored by The Cleveland Clinic.
- Active
- Registry status
- NA
- Development phase
- 67
- Enrollment target
- 1
- Study location
NCT04334668: Active NA study of Volume Overload, sponsored by The Cleveland Clinic.
NCT04334668 is a NA study of Volume Overload that is active but no longer recruiting, run by The Cleveland Clinic. The registered enrollment target is 67 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04334668, a NA study of Volume Overload, is active but no longer recruiting, sponsored by The Cleveland Clinic.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 67 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators are proposing a prospective, randomized, double blinded, placebo-controlled single center study evaluating the role of co-administration of oral sodium chloride (NaCl) with intravenous diuretics in patients hospitalized with acute decompensated heart failure. The investigators are approaching this study with the hypothesis that the use of oral sodium chloride leads to improved effective diuresis (as measured by weight loss) and renal function as compared to placebo in patients hospitalized with acute decompensated heart failure undergoing aggressive intravenous diuretic therapy.
Primary Outcome
Measured in kilograms
Conditions Studied
Interventions
- OTHER Placebo
- DIETARY_SUPPLEMENT Oral Sodium Chloride
Study Locations (1)
Ohio
- Cleveland Clinic - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 67 participants |
| Start Date | 2020-05-20 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
What the registry record for NCT04334668 still lists
NCT04334668 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 67 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Volume Overload appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT04334668 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT04334668 about?
NCT04334668 is a clinical study titled "Oral Sodium to Preserve Renal EfficiencY in Acute Heart Failure". The investigators are proposing a prospective, randomized, double blinded, placebo-controlled single center study evaluating the role of co-administration of oral sodium chloride (NaCl) with intravenous diuretics in patients hospitalized with acute decompensated heart failure. The investigators are ...
What is the current status of trial NCT04334668?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 67 participants. The study started on 2020-05-20. Estimated completion is 2026-12-31.
What conditions does trial NCT04334668 study?
This clinical trial studies the following conditions: Volume Overload.
What interventions are being tested in trial NCT04334668?
The interventions under investigation include: Placebo (OTHER), Oral Sodium Chloride (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT04334668?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04334668 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Volume Overload
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04334668's enrollment target sits among peer trials
67 1139th of 2000 higher than 862 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03213002 · 67 participants · Phase 1
Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM
- NCT04115163 · 67 participants · Phase 2
Biologically Optimized Infusion Schedule of Gemcitabine and Nab-Paclitaxel for the Treatment of Metastatic Pancreatic Cancer
- NCT04315324 · 67 participants · Phase 1
Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)
- NCT04532424 · 67 participants · NA
Transcranial Magnetic Stimulation for Restricted and Repetitive Behavior in ASD
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI