Dana-Farber Cancer Institute
Trial Pipeline
Pre-NEOSHIFT-RCC: Neoadjuvant HIF-Inhibitor Immunotherapy in RCC
NCT07397611
Individualizing Approaches to Surveillance Mammography in Older Breast Cancer Survivors - The I-MAMMO Study
NCT07123649
Feasibility Testing of a Tai Chi Program for Chemotherapy-Induced Peripheral Neuropathy Treatment (TCT)
NCT06807294
ACT Lung Health Intervention: Phase Two
NCT06945120
Cryocompression for CIPN
NCT07064798
HEME Home Transfusion Program
NCT06487247
Exercise and Nutrition for Older Cancer Survivors and Their Support Person: The Vitality Study
NCT06623097
Sleep Treatment Education Program for Cancer Survivors: STEP-Together
NCT06736548
Interrupting Sedentary Time to Improve Cardiometabolic Health and Toxicity in Patients With Lymphoma Receiving Chemotherapy: The iSTAND Trial
NCT06923397
BOLSTER: Learning New Skills to Thrive
NCT06936878
Resource Intervention to Support Equity (RISE) in High-Risk Neuroblastoma
NCT06831552
Proof-of-Concept Testing of the Cardiovascular Health Equity Through Food (CHEF) Intervention in Childhood Cancer Survivors
NCT06609473
EQUAL: EGFR ctDNA QUantative Assessment for Lung Cancer Screening in Asian and Latinx Populations
NCT06716580
Tools for Reducing Inequity in Acute Leukemia (TRIAL): Beta Testing
NCT06907797
Evaluation of Multi-Cancer Early Detection Testing in a High-Risk Military Population: The Sentinel Study
NCT06523868
Integrating Pain-CBT Into an mHealth Analgesic Support Intervention for Patients With Chronic Pain From Advanced Cancers
NCT06722014
REVITALIZE: RCT to Reduce Fatigue in Adults With Ovarian Cancer on PARP Inhibitors
NCT06710548
Dance Study for Post-surgical Pain in Breast Cancer Survivors
NCT06758102
Pilot Randomized Controlled Trial of a Collaborative Agenda-setting Intervention (CASI) for Patients With Ovarian Cancer
NCT06543537
Belzutifan in Recurrent Clear Cell Carcinoma of Gynecologic Origin
NCT06677190
The Impact of PReOPerative Exercise and NutritionaL Optimization on Perioperative Outcomes for Patients Undergoing Treatment for Rectal Cancer: The PROPEL Trial
NCT06565052
Driving Inclusivity, Validity, and Equity in Research Through Strategic Engagement (DIVERSE)
NCT06469307
A Phase 0 Window of Opportunity Trial of Intratumoral Seasonal Influenza Immunization in Cutaneous Squamous Cell Carcinoma (CSCC) Patients Awaiting Curative Excision
NCT06664151
Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL
NCT06475235
Intraperitoneal Cytokine-Induced Memory Like (CIML) Natural Killer (NK) Cells in Recurrent Ovarian Cancer
NCT06321484
Evaluation of Multi-Cancer Early Detection Testing in a High-Risk Population: The INFORM Study
NCT06450171
ALPINE: Maintenance Letrozole/Abemaciclib
NCT06366347
The COMPASSION Study
NCT06507930
Memory-like Natural Killer (NK) Cell Therapy in Patients With Renal Cell Carcinoma or Urothelial Carcinoma
NCT06318871
Phase Ib Study of Axatilimab in Combination With Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-negative Breast Cancer
NCT06488378
The SAPPHO Study: Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer
NCT06439693
Developing Restful Environments and Management Strategies for Pediatric Stem Cell Transplant Patients
NCT06468618
Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE Trial
NCT06202183
High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients: The DUO Trial
NCT06298734
BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP)
NCT05922761
LuCarbo - a Study of 177Lu-PSMA-617 Plus Carboplatin in Metastatic Castrate-resistant Prostate Cancer
NCT06303713
PediRISE Feasibility
NCT06283251
Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)
NCT06322888
Management of Cisplatin-Ineligible Patients With Metastatic Bladder Cancer and The Role of Geriatric Assessments
NCT06138561
CIML NK Cells With Venetoclax for AML
NCT06152809
RecoverPC: Relugolix vs GnRH Agonist in Quality of Life
NCT05765500
Preliminary Efficacy of Different Exercise Training During Immunotherapy in Patients With Lung Cancer: The ENHANCE Trial
NCT06026111
Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation
NCT06138587
CV CARE: CardioVascular Care in PC Patients
NCT06202820
Debunking the Frailty-sarcopenIa-ADT Axis in mEtastatic Prostate canceR With multiComponent Exercise: The FIERCE Trial
NCT06040125
High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumors: A Pilot Feasibility Study
NCT05740839
Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals
NCT06122896
Promoting Resilience in Early Survivorship Among Adolescents and Young Adults With Cancer
NCT06038318
A Novel Imaging Protocol in Use to Identify Lymph Nodes and Organs of Interest
NCT05899361
Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation
NCT05706766
Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCC
NCT05726370
Pirtobrutinib and Venetoclax in Waldenström Macroglobulinemia
NCT05734495
Enhancing Information Management for Young Adults After Genetic Cancer Risk Testing
NCT05759143
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
NCT05463796
TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients
NCT05535192
A Novel Intervention for Patients With Cancer
NCT05643027
Patient-Centered Surgical Prehabilitation
NCT05715684
Investigating Hereditary Risk In Thoracic Cancers (INHERIT)
NCT05587439
Biology of Young Lung Cancer Study: The YOUNG LUNG Study
NCT05265429
Resistance Exercise Combined With Protein Supplementation in People With Pancreatic Cancer: The RE-BUILD Trial
NCT05356117
Exercise to Enhance Cardiovascular Health Among Black Prostate Cancer Patients With Androgen Deprivation Therapy
NCT05327465
Video Education With Result Dependent dIsclosure
NCT05225428
Intraoral Photobiomodulation Therapy to Prevent Oral Mucositis in Patients Undergoing Hematopoietic Cell Transplantation
NCT05335434
Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial
NCT05236062
Exercise as a Preventive Agent to Combat Immobility in Patients With Ovarian or Endometrial Cancers Receiving Chemotherapy
NCT04997096
Zanubrutinib and Venetoclax in CLL (ZANU-VEN)
NCT05168930
UPLYFT For Lymphoma Survivors
NCT05080166
Resilience and Equity in Aging, Cancer, and Health (REACH)
NCT04674267
NeoVax + CDX-301 and Nivolumab or Pembrolizumab in Melanoma
NCT04930783
Stereotactic Body Radiotherapy (SBRT) for Early Treatment of Oligometastatic Adenoid Cystic Carcinoma: The SOLAR Trial
NCT04883671
Scalp Cooling in MBC
NCT04986579
Geriatric Thoracic Surgery Ambulation Challenge
NCT04630496
A Personalized Neoantigen Cancer Vaccine in Treatment Naïve, Asymptomatic Patients With IGHV Unmutated CLL.
NCT03219450
Concurrent Laparoscopic Hysterectomy and Weight Loss Surgery in Obese Patients With Endometrial Carcinoma or Endometrial Intraepithelial Neoplasia
NCT04839614
Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy
NCT04724499
ATEMPT 2.0: Adjuvant T-DM1 vs TH
NCT04893109
Protocol For Genomically Profiling, Collecting, Archiving And Distributing Blood And Bone Marrow Specimens From Children And Young Adults With Hematologic Malignancy
NCT04968834
Refining Local-Regional Therapy for IBC
NCT04636710
Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer
NCT04789486
Sacituzumab Govitecan Plus EV in Metastatic UC
NCT04724018
IS-free Treg HaploHCT
NCT04678401
A Single Arm Phase II Study of ADjuvant Endocrine Therapy, Pertuzumab, and Trastuzumab for Patients With Anatomic Stage I Hormone Receptor-positive, HER2-positive Breast Cancer
NCT04569747
Post-op T-DM1 in HER-2+ Salivary Gland Carcinomas
NCT04620187
Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress
NCT04541654
Pembrolizumab, Ibrutinib and Rituximab in PCNSL
NCT04421560
Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC
NCT04468061
Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)
NCT04434040
Serial MRI Scans During Radiation Therapy
NCT04188535
A Pilot of a Microdevice For In Situ Candidate Drug Screening in Cutaneous Lesions of T-Cell Lymphoma
NCT04045470
Stereotactic Magnetic Resonance Guided Radiation Therapy
NCT04115254
A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation
NCT04024761
Study of De_Intensified Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma
NCT03875716
RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer
NCT03675893
Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)
NCT03689595
Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers
NCT03683680
Osimertinib In EGFR Mutant Lung Cancer
NCT03586453
Liquid Biopsy in Ewing Sarcoma and Osteosarcoma as a Prognostic And Response Diagnostic: LEOPARD
NCT06068075
Study of the CDK4/6 Inhibitor Abemaciclib in Solid Tumors Harboring Genetic Alterations in Genes Encoding D-Type Cyclins or Amplification of CDK4 or CDK6
NCT03310879
Venetoclax and Chemotherapy as Frontline Therapy in Older Patients and Patients With Relapsed/Refractory ALL
NCT03319901
SL-401 in Combination With Azacitidine or Azacitidine/Venetoclax in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
NCT03113643
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 133 |
| Phase 2 | 196 |
| Phase 3 | 3 |
Therapeutic Areas
What the Pipeline for Dana-Farber Cancer Institute Shows
According to the ClinicalTrials.gov registry, Dana-Farber Cancer Institute is linked to 819 US clinical trials across every stage of research activity. Of those, 588 studies are currently recruiting — about 72% of the sponsor's indexed portfolio — and 115 are already marked complete, representing roughly 14% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
The phase mix for Dana-Farber Cancer Institute reports 3 late-stage studies (Phase 3 and Phase 4 combined) and 329 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
The top therapeutic focus area indexed for Dana-Farber Cancer Institute is Breast Cancer with 53 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology — how this data is sourced, computed, and verified.