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NCT05568654 · ClinicalTrials.gov registry record · NA

Reducing Antimicrobial Overuse Through Targeted Therapy for Patients With Community-Acquired Pneumonia

A NA study of Community-acquired Pneumonia and Antimicrobial Stewardship, sponsored by The Cleveland Clinic.

Active
Registry status
NA
Development phase
12,500
Enrollment target
12
Study locations

NCT05568654 is a NA study of Community-acquired Pneumonia and Antimicrobial Stewardship that is active but no longer recruiting, run by The Cleveland Clinic. The registered enrollment target is 12,500 participants, below the 107,732-participant average among 9 other Community-acquired Pneumonia trials with a reported enrollment target (88% lower). The trial reports 12 study locations across 2 states.

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The verdict

NCT05568654, a NA study of Community-acquired Pneumonia and Antimicrobial Stewardship, is active but no longer recruiting, sponsored by The Cleveland Clinic.

ACTIVE NOT RECRUITING
Registry status
NA
Development phase
12,500 participants
Enrollment target
12
Study locations

Study Summary

The purpose of this study is to reduce the exposure of broad-spectrum antimicrobials by optimizing the rapid detection of CAP pathogens and improving rates of de-escalation following negative cultures. To accomplish this, we will perform a 3-year, pragmatic, multicenter 2 X 2 factorial cluster randomized controlled trial with four arms: a) rapid diagnostic testing b) pharmacist-led de-escalation c) rapid diagnostic testing + pharmacist-led de-escalation and d) usual care

Conditions Studied

Community-acquired Pneumonia Antimicrobial Stewardship Point-of-Care Testing

Interventions

  • DIAGNOSTIC_TEST Rapid Diagnostic Testing
  • OTHER Pharmacist-led de-escalation

Study Locations (12)

Ohio

  • Akron General Hospital - Akron
  • Avon Hospital - Avon
  • Lutheran Hospital - Cleveland
  • Cleveland Clinic Main Campus - Cleveland
  • Euclid Hospital - Euclid
  • Fairview Hospital - Fairview Park
  • Marymount Hospital - Garfield Heights
  • Hillcrest Hospital - Mayfield Heights
  • Medina Hospital - Medina
  • South Pointe Hospital - Warrensville Heights

Florida

  • Indian River Hospital - Vero Beach
  • Weston Hospital/Cleveland Clinic Florida - Weston

Trial Details

FieldValue
Enrollment Target 12,500 participants
Start Date 2022-11-01
Est. Completion 2026-06-30
Phase NA

Sponsor

The Cleveland Clinic

688 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05568654

The ClinicalTrials.gov registry entry for NCT05568654 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 12,500 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 107,732-participant average among 9 other Community-acquired Pneumonia trials with a reported enrollment target (88% lower). The listed sponsor is The Cleveland Clinic, which has 688 total studies on file at ClinicalTrials.gov.

The record links to 3 conditions, with Community-acquired Pneumonia appearing as the primary indexed condition, and to 2 interventions - of which Rapid Diagnostic Testing is the first listed.

NCT05568654 reports 12 study locations spanning 2 distinct geographic areas - top geographies include Ohio, Florida.

Frequently Asked Questions

What is clinical trial NCT05568654 about?

NCT05568654 is a clinical study titled "Reducing Antimicrobial Overuse Through Targeted Therapy for Patients With Community-Acquired Pneumonia". The purpose of this study is to reduce the exposure of broad-spectrum antimicrobials by optimizing the rapid detection of CAP pathogens and improving rates of de-escalation following negative cultures. To accomplish this, we will perform a 3-year, pragmatic, multicenter 2 X 2 factorial cluster rando...

What is the current status of trial NCT05568654?

This trial is currently active not recruiting. It is a NA study. The enrollment target is 12,500 participants. The study started on 2022-11-01. Estimated completion is 2026-06-30.

What conditions does trial NCT05568654 study?

This clinical trial studies the following conditions: Community-acquired Pneumonia, Antimicrobial Stewardship, Point-of-Care Testing.

What interventions are being tested in trial NCT05568654?

The interventions under investigation include: Rapid Diagnostic Testing (DIAGNOSTIC_TEST), Pharmacist-led de-escalation (OTHER).

Who is sponsoring clinical trial NCT05568654?

This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05568654 being conducted?

This trial has 12 study locations across Florida, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.