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NCT05568654 · ClinicalTrials.gov registry record · NA
Reducing Antimicrobial Overuse Through Targeted Therapy for Patients With Community-Acquired Pneumonia
A NA study of Community-acquired Pneumonia and Antimicrobial Stewardship, sponsored by The Cleveland Clinic.
- Active
- Registry status
- NA
- Development phase
- 12,500
- Enrollment target
- 12
- Study locations
NCT05568654: Active NA study of Community-acquired Pneumonia and Antimicrobial Stewardship, sponsored by The Cleveland Clinic.
NCT05568654 is a NA study of Community-acquired Pneumonia and Antimicrobial Stewardship that is active but no longer recruiting, run by The Cleveland Clinic. The registered enrollment target is 12,500 participants, below the 107,732-participant average among 9 other Community-acquired Pneumonia trials with a reported enrollment target (88% lower). The trial reports 12 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05568654, a NA study of Community-acquired Pneumonia and Antimicrobial Stewardship, is active but no longer recruiting, sponsored by The Cleveland Clinic.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 12,500 participants
- Enrollment target
- 12
- Study locations
Study Summary
The purpose of this study is to reduce the exposure of broad-spectrum antimicrobials by optimizing the rapid detection of CAP pathogens and improving rates of de-escalation following negative cultures. To accomplish this, we will perform a 3-year, pragmatic, multicenter 2 X 2 factorial cluster randomized controlled trial with four arms: a) rapid diagnostic testing b) pharmacist-led de-escalation c) rapid diagnostic testing + pharmacist-led de-escalation and d) usual care
Primary Outcome
duration of exposure to broad-spectrum antimicrobial therapy defined by the number of days of antibiotic therapy in the first 21 days of admission as per National Healthcare Safety Network (NHSN) guidelines
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Rapid Diagnostic Testing
- OTHER Pharmacist-led de-escalation
Study Locations (12)
Ohio
- Akron General Hospital - Akron
- Avon Hospital - Avon
- Lutheran Hospital - Cleveland
- Cleveland Clinic Main Campus - Cleveland
- Euclid Hospital - Euclid
- Fairview Hospital - Fairview Park
- Marymount Hospital - Garfield Heights
- Hillcrest Hospital - Mayfield Heights
- Medina Hospital - Medina
- South Pointe Hospital - Warrensville Heights
Florida
- Indian River Hospital - Vero Beach
- Weston Hospital/Cleveland Clinic Florida - Weston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12,500 participants |
| Start Date | 2022-11-01 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
What the registry record for NCT05568654 still lists
NCT05568654 is an interventional study that assigns participants to a tested intervention. Its 12,500 participants enrollment target places it among the larger protocols in the corpus, below the 107,732-participant average among 9 other Community-acquired Pneumonia trials with a reported enrollment target (88% lower).
The record links to 3 conditions, with Community-acquired Pneumonia appearing as the primary indexed condition, and to 2 interventions - of which Rapid Diagnostic Testing is the first listed.
NCT05568654 lists 12 locations in 2 states (Ohio, Florida).
Frequently Asked Questions
What is clinical trial NCT05568654 about?
NCT05568654 is a clinical study titled "Reducing Antimicrobial Overuse Through Targeted Therapy for Patients With Community-Acquired Pneumonia". The purpose of this study is to reduce the exposure of broad-spectrum antimicrobials by optimizing the rapid detection of CAP pathogens and improving rates of de-escalation following negative cultures. To accomplish this, we will perform a 3-year, pragmatic, multicenter 2 X 2 factorial cluster rando...
What is the current status of trial NCT05568654?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 12,500 participants. The study started on 2022-11-01. Estimated completion is 2026-06-30.
What conditions does trial NCT05568654 study?
This clinical trial studies the following conditions: Community-acquired Pneumonia, Antimicrobial Stewardship, Point-of-Care Testing.
What interventions are being tested in trial NCT05568654?
The interventions under investigation include: Rapid Diagnostic Testing (DIAGNOSTIC_TEST), Pharmacist-led de-escalation (OTHER).
Who is sponsoring clinical trial NCT05568654?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05568654 being conducted?
This trial has 12 study locations across Florida, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05568654's enrollment target sits among peer trials
12,500 2nd of 9 the highest of 9 other Community-acquired Pneumonia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Community-acquired Pneumonia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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