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Reducing Antimicrobial Overuse Through Targeted Therapy for Patients With Community-Acquired Pneumonia
NCT05568654 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to reduce the exposure of broad-spectrum antimicrobials by optimizing the rapid detection of CAP pathogens and improving rates of de-escalation following negative cultures. To accomplish this, we will perform a 3-year, pragmatic, multicenter 2 X 2 factorial cluster randomized controlled trial with four arms: a) rapid diagnostic testing b) pharmacist-led de-escalation c) rapid diagnostic testing + pharmacist-led de-escalation and d) usual care
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Rapid Diagnostic Testing
- OTHER Pharmacist-led de-escalation
Study Locations (12)
Ohio
- Akron General Hospital — Akron
- Avon Hospital — Avon
- Lutheran Hospital — Cleveland
- Cleveland Clinic Main Campus — Cleveland
- Euclid Hospital — Euclid
- Fairview Hospital — Fairview Park
- Marymount Hospital — Garfield Heights
- Hillcrest Hospital — Mayfield Heights
- Medina Hospital — Medina
- South Pointe Hospital — Warrensville Heights
Florida
- Indian River Hospital — Vero Beach
- Weston Hospital/Cleveland Clinic Florida — Weston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12,500 participants |
| Start Date | 2022-11-01 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05568654
The ClinicalTrials.gov registry entry for NCT05568654 describes a study currently listed as active not recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 12,500 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is The Cleveland Clinic, which has 607 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Antimicrobial Stewardship appearing as the primary indexed condition, and to 2 interventions — of which Rapid Diagnostic Testing is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05568654 reports 12 study locations spanning 2 distinct geographic areas — top geographies include Ohio, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05568654 about?
NCT05568654 is a clinical study titled "Reducing Antimicrobial Overuse Through Targeted Therapy for Patients With Community-Acquired Pneumonia". The purpose of this study is to reduce the exposure of broad-spectrum antimicrobials by optimizing the rapid detection of CAP pathogens and improving rates of de-escalation following negative cultures. To accomplish this, we will perform a 3-year, pragmatic, multicenter 2 X 2 factorial cluster rando...
What is the current status of trial NCT05568654?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 12,500 participants. The study started on 2022-11-01. Estimated completion is 2026-06-30.
What conditions does trial NCT05568654 study?
This clinical trial studies the following conditions: Antimicrobial Stewardship, Community-Acquired Pneumonia, Point-of-Care Testing. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05568654?
The interventions under investigation include: Rapid Diagnostic Testing (DIAGNOSTIC_TEST), Pharmacist-led de-escalation (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05568654?
This trial is sponsored by The Cleveland Clinic, which has 607 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05568654 being conducted?
This trial has 12 study locations across Florida, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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