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NCT07315204 · ClinicalTrials.gov registry record
Viability Assessment Using FMN Measured in Perfusate and Bile During Normothermic Machine Perfusion
A clinical trial of Liver Transplant Disorder, sponsored by The Cleveland Clinic.
- Recruiting
- Registry status
- 850
- Enrollment target
- 1
- Study location
NCT07315204: Recruiting study of Liver Transplant Disorder, sponsored by The Cleveland Clinic.
NCT07315204 is a study of Liver Transplant Disorder that is actively recruiting participants, run by The Cleveland Clinic. The registered enrollment target is 850 participants, above the 28-participant average among 3 other Liver Transplant Disorder trials with a reported enrollment target (2936% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07315204, a study of Liver Transplant Disorder, is actively recruiting participants, sponsored by The Cleveland Clinic.
- RECRUITING
- Registry status
- 850 participants
- Enrollment target
- 1
- Study location
Study Summary
Discarded perfusate samples will be collected from donors after circulatory death (DCD) or donors after brain death (DBD) organs during the machine perfusion period prior to transplantation by the study team. FMN will be measured as is standard of care for all machine perfusion liver transplant cases at Cleveland Clinic. Participating centers will be provided with sample collection and shipping instructions to ensure sample preservation in accordance with IATA guidelines. Samples from outside sites will not be stored for future research and will be discarded once analysis is completed. After the collection of the samples from machine perfusion, the transplant procedure will continue according to standard process.
Primary Outcome
Graft functionality measured by perfusate FMN, bile FMN, and perfusate + bile FMN. Graft viability measured by primary non-function (PNF). Non-anastomotic stricture (NAS), other graft related loss - death censored.
Conditions Studied
Study Locations (1)
Ohio
- Cleveland Clinic Foundation - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 850 participants |
| Start Date | 2025-12-29 |
| Est. Completion | 2028-12-31 |
What NCT07315204 shows while recruiting
NCT07315204 is an observational study that tracks outcomes without assigning an intervention. The registered 850 participants enrollment target is mid-sized for trials with a published cap, above the 28-participant average among 3 other Liver Transplant Disorder trials with a reported enrollment target (2936% higher).
The record links to 1 condition, with Liver Transplant Disorder appearing as the primary indexed condition, and to 0 interventions.
NCT07315204 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT07315204 about?
NCT07315204 is a clinical study titled "Viability Assessment Using FMN Measured in Perfusate and Bile During Normothermic Machine Perfusion". Discarded perfusate samples will be collected from donors after circulatory death (DCD) or donors after brain death (DBD) organs during the machine perfusion period prior to transplantation by the study team. FMN will be measured as is standard of care for all machine perfusion liver transplant case...
What is the current status of trial NCT07315204?
This trial is currently recruiting. The enrollment target is 850 participants. The study started on 2025-12-29. Estimated completion is 2028-12-31.
What conditions does trial NCT07315204 study?
This clinical trial studies the following conditions: Liver Transplant Disorder.
Who is sponsoring clinical trial NCT07315204?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07315204 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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