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NCT06780241 · ClinicalTrials.gov registry record
Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease
A clinical trial of Aortic Stenosis and Mitral Regurgitation, sponsored by The Cleveland Clinic.
- Recruiting
- Registry status
- 200
- Enrollment target
- 1
- Study location
NCT06780241: Recruiting study of Aortic Stenosis and Mitral Regurgitation, sponsored by The Cleveland Clinic.
NCT06780241 is a study of Aortic Stenosis and Mitral Regurgitation that is actively recruiting participants, run by The Cleveland Clinic. The registered enrollment target is 200 participants, below the 1,355-participant average among 26 other Aortic Stenosis trials with a reported enrollment target (85% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06780241, a study of Aortic Stenosis and Mitral Regurgitation, is actively recruiting participants, sponsored by The Cleveland Clinic.
- RECRUITING
- Registry status
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
This project aims to validate sex-specific biologic signatures associated with aortic valve disease developed in a large multicenter CMR registry, using unsupervised phenomapping. The aim to use standard and advanced CMR techniques (MRF, DTI, chemical exchange transfer, and radiomics analysis) is to determine advanced CMR predictors of reverse remodeling following aortic valve surgery and develop sex-specific thresholds for risk. Infrastructure developed by this study will enable development of an innovative, scalable, sex-specific precision medicine cardiovascular imaging pipeline to determine overall risk and treatment response.
Primary Outcome
Significant change in LV remodeling will be defined as a change in EF by 10 units (reverse remodeling is defined at least 10 unit decrease) or change in LV end-diastolic/systolic volume by 10% (Reverse remodeling is defined as at least decrease in LV end-diastolic/systolic volume by 10%
Conditions Studied
Interventions
- DIAGNOSTIC_TEST CMR
- OTHER Quality of Life Questionnaire
Study Locations (1)
Ohio
- Cleveland Clinic - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2024-12-10 |
| Est. Completion | 2030-12-31 |
What NCT06780241 shows while recruiting
NCT06780241 is an observational study that tracks outcomes without assigning an intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, below the 1,355-participant average among 26 other Aortic Stenosis trials with a reported enrollment target (85% lower).
The record links to 3 conditions, with Aortic Stenosis appearing as the primary indexed condition, and to 2 interventions - of which CMR is the first listed.
NCT06780241 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT06780241 about?
NCT06780241 is a clinical study titled "Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease". This project aims to validate sex-specific biologic signatures associated with aortic valve disease developed in a large multicenter CMR registry, using unsupervised phenomapping. The aim to use standard and advanced CMR techniques (MRF, DTI, chemical exchange transfer, and radiomics analysis) is t...
What is the current status of trial NCT06780241?
This trial is currently recruiting. The enrollment target is 200 participants. The study started on 2024-12-10. Estimated completion is 2030-12-31.
What conditions does trial NCT06780241 study?
This clinical trial studies the following conditions: Aortic Stenosis, Mitral Regurgitation, Aortic Regurgitation.
What interventions are being tested in trial NCT06780241?
The interventions under investigation include: CMR (DIAGNOSTIC_TEST), Quality of Life Questionnaire (OTHER).
Who is sponsoring clinical trial NCT06780241?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06780241 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Aortic Stenosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06780241's enrollment target sits among peer trials
200 15th of 26 higher than 10 of 26 other Aortic Stenosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aortic Stenosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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