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NCT06780241 · ClinicalTrials.gov registry record

Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

A clinical trial of Aortic Stenosis and Mitral Regurgitation, sponsored by The Cleveland Clinic.

Recruiting
Registry status
200
Enrollment target
1
Study location

NCT06780241 is a study of Aortic Stenosis and Mitral Regurgitation that is actively recruiting participants, run by The Cleveland Clinic. The registered enrollment target is 200 participants, below the 1,355-participant average among 26 other Aortic Stenosis trials with a reported enrollment target (85% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06780241, a study of Aortic Stenosis and Mitral Regurgitation, is actively recruiting participants, sponsored by The Cleveland Clinic.

RECRUITING
Registry status
200 participants
Enrollment target
1
Study location

Study Summary

This project aims to validate sex-specific biologic signatures associated with aortic valve disease developed in a large multicenter CMR registry, using unsupervised phenomapping. The aim to use standard and advanced CMR techniques (MRF, DTI, chemical exchange transfer, and radiomics analysis) is to determine advanced CMR predictors of reverse remodeling following aortic valve surgery and develop sex-specific thresholds for risk. Infrastructure developed by this study will enable development of an innovative, scalable, sex-specific precision medicine cardiovascular imaging pipeline to determine overall risk and treatment response.

Conditions Studied

Aortic Stenosis Mitral Regurgitation Aortic Regurgitation

Interventions

  • DIAGNOSTIC_TEST CMR
  • OTHER Quality of Life Questionnaire

Study Locations (1)

Ohio

  • Cleveland Clinic - Cleveland

Trial Details

FieldValue
Enrollment Target 200 participants
Start Date 2024-12-10
Est. Completion 2030-12-31

Sponsor

The Cleveland Clinic

688 total trials

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What the Registry Record Tells You About NCT06780241

The ClinicalTrials.gov registry entry for NCT06780241 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,355-participant average among 26 other Aortic Stenosis trials with a reported enrollment target (85% lower). The listed sponsor is The Cleveland Clinic, which has 688 total studies on file at ClinicalTrials.gov.

The record links to 3 conditions, with Aortic Stenosis appearing as the primary indexed condition, and to 2 interventions - of which CMR is the first listed.

NCT06780241 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.

Frequently Asked Questions

What is clinical trial NCT06780241 about?

NCT06780241 is a clinical study titled "Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease". This project aims to validate sex-specific biologic signatures associated with aortic valve disease developed in a large multicenter CMR registry, using unsupervised phenomapping. The aim to use standard and advanced CMR techniques (MRF, DTI, chemical exchange transfer, and radiomics analysis) is t...

What is the current status of trial NCT06780241?

This trial is currently recruiting. The enrollment target is 200 participants. The study started on 2024-12-10. Estimated completion is 2030-12-31.

What conditions does trial NCT06780241 study?

This clinical trial studies the following conditions: Aortic Stenosis, Mitral Regurgitation, Aortic Regurgitation.

What interventions are being tested in trial NCT06780241?

The interventions under investigation include: CMR (DIAGNOSTIC_TEST), Quality of Life Questionnaire (OTHER).

Who is sponsoring clinical trial NCT06780241?

This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06780241 being conducted?

This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.