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NCT06946368 · ClinicalTrials.gov registry record · NA

Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery

A NA study of Total Knee Arthroplasty, sponsored by The Cleveland Clinic.

Recruiting
Registry status
NA
Development phase
60
Enrollment target
1
Study location

NCT06946368 is a NA study of Total Knee Arthroplasty that is actively recruiting participants, run by The Cleveland Clinic. The registered enrollment target is 60 participants, below the 293-participant average among 29 other Total Knee Arthroplasty trials with a reported enrollment target (80% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06946368, a NA study of Total Knee Arthroplasty, is actively recruiting participants, sponsored by The Cleveland Clinic.

RECRUITING
Registry status
NA
Development phase
60 participants
Enrollment target
1
Study location

Study Summary

Intra-articular Posteromedial Surgeon Administered (IPSA) Block in this study describes a new type of medical procedure where a surgeon provides anesthetic medication directly into a specific area inside a knee joint to numb the pain during knee surgery. Intra-articular refers to inside of knee joint, posteromedial refers to the back and inner side of a knee joint, and surgeon administered means a surgeon is performing the procedure. Patients You will be randomly assigned to one of these three treatment groups: Group 1: Patients in this group will receive IPSA block and Local Infiltration Analgesia (LIA). IPSA block is a pain numbing medication given by surgeon and injected inside the back and inner side of the knee joint. Local Infiltration Analgesia is a pain numbing medication injection given by the surgeon around the surgical knee area. The medications used in the procedure will be EXPAREL, and Bupivacaine HCL. Group 2 (Control): Patients in this group will receive Adductor Canal Block (ACB) and Local Infiltration Analgesia (LIA). ACB is a pain numbing injection given by anesthesiologist near the adductor canal, a passage in the mid-thigh that contains nerves connecting the knee region. Local Infiltration Analgesia is a pain numbing medication injection given by the surgeon around the surgical knee area. The medications used in the procedure will be EXPAREL, and Bupivacaine HCL. Group 3: Patients in this group will receive Local Infiltration Analgesia (LIA). Local Infiltration Analgesia is a pain numbing medication injection given by the surgeon around the surgical knee area. The medications used in the procedure will be EXPAREL, and Bupivacaine HCL. The study will evaluate; * How effective the pain relief is after surgery. * How much extra pain medication you need. * Your satisfaction with pain management and recovery * Any side effects.

Conditions Studied

Total Knee Arthroplasty

Interventions

  • PROCEDURE Intra-articular Posteromedial Surgeon Administered (IPSA) Block of EXPAREL
  • PROCEDURE Adductor Canal Block (ACB) and Local Local Infiltration Analgesia of EXPAREL
  • PROCEDURE Local Infiltration Analgesia (LIA) of EXPAREL

Study Locations (1)

Ohio

  • Cleveland Clinic Lutheran Hospital - Cleveland

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2025-08-18
Est. Completion 2026-12-11
Phase NA

Sponsor

The Cleveland Clinic

688 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06946368

The ClinicalTrials.gov registry entry for NCT06946368 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 293-participant average among 29 other Total Knee Arthroplasty trials with a reported enrollment target (80% lower). The listed sponsor is The Cleveland Clinic, which has 688 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Total Knee Arthroplasty appearing as the primary indexed condition, and to 3 interventions - of which Intra-articular Posteromedial Surgeon Administered (IPSA) Block of EXPAREL is the first listed.

NCT06946368 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.

Frequently Asked Questions

What is clinical trial NCT06946368 about?

NCT06946368 is a clinical study titled "Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery". Intra-articular Posteromedial Surgeon Administered (IPSA) Block in this study describes a new type of medical procedure where a surgeon provides anesthetic medication directly into a specific area inside a knee joint to numb the pain during knee surgery. Intra-articular refers to inside of knee join...

What is the current status of trial NCT06946368?

This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2025-08-18. Estimated completion is 2026-12-11.

What conditions does trial NCT06946368 study?

This clinical trial studies the following conditions: Total Knee Arthroplasty.

What interventions are being tested in trial NCT06946368?

The interventions under investigation include: Intra-articular Posteromedial Surgeon Administered (IPSA) Block of EXPAREL (PROCEDURE), Adductor Canal Block (ACB) and Local Local Infiltration Analgesia of EXPAREL (PROCEDURE), Local Infiltration Analgesia (LIA) of EXPAREL (PROCEDURE).

Who is sponsoring clinical trial NCT06946368?

This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06946368 being conducted?

This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.