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ClinicalTrials.gov 147 recruiting now official registry

Ovarian Cancer clinical trials

147 of 338 indexed Ovarian Cancer trials are currently recruiting.

338 US clinical trials · 147 currently recruiting

Ovarian Cancer is the subject of 338 registered US clinical trials on ClinicalTrials.gov, 147 of them currently open to new participants. 28 are in Phase 3-4 (later-stage) and 230 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 31 of these trials.

The research picture

Ovarian Cancer has 338 registered US clinical trials, 147 of them open to new participants right now, about 43% of the total.

147
recruiting participants now
43%
of trials open to enrollment
28
in Phase 3–4 (later-stage)
31
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 1143Phase 287Phase 325Phase 43

Active & Recent Trials

338 total, page 4 of 7

ACTIVE NOT RECRUITING 1,315 participants

Estrogen, Diet, Genetics and Endometrial Cancer

Memorial Sloan Kettering Cancer Center

NCT00587886

ACTIVE NOT RECRUITING 1,047 participants

Evaluating an Alternative Clinical Genetics Cancer Care Delivery Model: A Pilot Study of Patient Outcomes

Memorial Sloan Kettering Cancer Center

NCT02917798

ACTIVE NOT RECRUITING 1,000 participants

Tempus Priority Study: A Pan-tumor Observational Study

Tempus AI

NCT05179824

ACTIVE NOT RECRUITING Phase 1 914 participants

Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

Exelixis

NCT03170960

ACTIVE NOT RECRUITING Phase 1 840 participants

A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid Tumors

TScan Therapeutics

NCT05973487

ACTIVE NOT RECRUITING NA 797 participants

Trial on Radical Upfront Surgery in Advanced Ovarian Cancer

AGO Study Group

NCT02828618

ACTIVE NOT RECRUITING Phase 1 733 participants

Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC

OncoC4

NCT04140526

ACTIVE NOT RECRUITING Phase 1 702 participants

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

AstraZeneca

NCT04644068

ACTIVE NOT RECRUITING Phase 3 643 participants

Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).

Merck Sharp & Dohme

NCT05116189

ACTIVE NOT RECRUITING Phase 3 615 participants

Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery

CanariaBio

NCT04498117

ACTIVE NOT RECRUITING Phase 2 534 participants

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)

Hoffmann-La Roche

NCT02568267

ACTIVE NOT RECRUITING Phase 1 499 participants

Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer

Agenus

NCT03860272

ACTIVE NOT RECRUITING Phase 1 409 participants

Depression Treatment and Screening in Ovarian Cancer Patients

M.D. Anderson Cancer Center

NCT00515372

ACTIVE NOT RECRUITING NA 326 participants

Living WELL: A Web-Based Program for Ovarian Cancer Survivors

Susan Lutgendorf

NCT04533763

ACTIVE NOT RECRUITING Phase 1 288 participants

Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression

BicycleTx Limited

NCT04180371

ACTIVE NOT RECRUITING 240 participants

Biobehavioral and Sociodemographic Characteristics of Long Term Survivors of Ovarian Cancer

M.D. Anderson Cancer Center

NCT02043158

ACTIVE NOT RECRUITING Phase 2 225 participants

A Study of Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS Mutation

Verastem

NCT04625270

ACTIVE NOT RECRUITING Phase 3 220 participants

Randomized Study Comparing Two Dosing Schedules for Hypofractionated Image-Guided Radiation Therapy

Memorial Sloan Kettering Cancer Center

NCT01223248

ACTIVE NOT RECRUITING Phase 3 185 participants

Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Olaparib

AstraZeneca

NCT04421963

ACTIVE NOT RECRUITING Phase 2 184 participants

Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors

ImmunoVaccine Technologies, Inc. (IMV Inc.)

NCT03836352

ACTIVE NOT RECRUITING Phase 1 180 participants

P-MUC1C-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Advanced or Metastatic Solid Tumors

Poseida Therapeutics

NCT05239143

ACTIVE NOT RECRUITING Phase 2 176 participants

A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors

Hoffmann-La Roche

NCT04931342

ACTIVE NOT RECRUITING Phase 2 170 participants

A Study of XmAb20717 (Vudalimab)in Patients With Selected Advanced Gynecologic and Genitourinary Malignancies

Xencor

NCT05032040

ACTIVE NOT RECRUITING Phase 2 162 participants

Study to Compare the Efficacy and Safety of Olaparib When Given in Combination With Carboplatin and Paclitaxel, Compared With Carboplatin and Paclitaxel in Patients With Advanced Ovarian Cancer

AstraZeneca

NCT01081951

ACTIVE NOT RECRUITING Phase 2 154 participants

PF-07104091 as a Single Agent and in Combination Therapy

Pfizer

NCT04553133

ACTIVE NOT RECRUITING Phase 1 138 participants

A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors

Toray Industries

NCT03872947

ACTIVE NOT RECRUITING Phase 1 120 participants

ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)

Uswm CT

NCT04044859

ACTIVE NOT RECRUITING Phase 1 110 participants

COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies

Compugen

NCT04354246

ACTIVE NOT RECRUITING 100 participants

Diet, Hepcidin, and Chemotherapy RDI

George Washington University

NCT06483997

ACTIVE NOT RECRUITING Phase 1 97 participants

A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants with Advanced Unresectable or Metastatic Solid Tumors

NextCure

NCT05572684

ACTIVE NOT RECRUITING Phase 2 92 participants

A Trial of Vigil for Participants With Ovarian Cancer

Gradalis

NCT02346747

ACTIVE NOT RECRUITING 78 participants

Assessing the Time Demands of Cancer

Masonic Cancer Center, University of Minnesota

NCT05708703

ACTIVE NOT RECRUITING Phase 2 75 participants

Juice Plus+ and Juice Plus+ Complete in Ovarian Cancer

M.D. Anderson Cancer Center

NCT01439659

ACTIVE NOT RECRUITING Phase 2 73 participants

A Phase II Study Of Nivolumab/ Bevacizumab/Rucaparib

Dana-Farber Cancer Institute

NCT02873962

ACTIVE NOT RECRUITING Phase 1 71 participants

MAGE-A4ᶜ¹º³²T for Multi-Tumor

Adaptimmune

NCT03132922

ACTIVE NOT RECRUITING Phase 3 68 participants

Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing

Pfizer

NCT05059522

ACTIVE NOT RECRUITING Phase 2 66 participants

ADP-A2M4CD8 Monotherapy and in Combination With Nivolumab in HLA-A2+ Subjects With MAGE-A4 Positive Ovarian Cancer (SURPASS-3)

Uswm CT

NCT05601752

ACTIVE NOT RECRUITING Phase 2 63 participants

Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302)

EMD Serono Research & Development Institute

NCT06433219

ACTIVE NOT RECRUITING 60 participants

Diagnostic Utility of Culdocentesis in Patients With a Suspicious Adnexal Mass

Southern Illinois University

NCT02109367

ACTIVE NOT RECRUITING Phase 2 58 participants

ONC-392 and Pembrolizumab in Platinum Resistant Ovarian Cancer

OncoC4

NCT05446298

ACTIVE NOT RECRUITING Phase 1 57 participants

Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer

TCR2 Therapeutics

NCT03907852

ACTIVE NOT RECRUITING Phase 1 50 participants

PARP-inhibition and CTLA-4 Blockade in BRCA-deficient Ovarian Cancer

New Mexico Cancer Research Alliance

NCT02571725

ACTIVE NOT RECRUITING Phase 2 46 participants

BrUOG 354 Nivolumab +/- Ipilimumab for Ovarian and Extra-renal Clear Cell Carcinomas

Brown University

NCT03355976

ACTIVE NOT RECRUITING Phase 1 45 participants

A Phase 1 Clinical Study of NXP800 in Subjects With Advanced Cancers and Expansion in Subjects With Ovarian Cancer

Nuvectis Pharma

NCT05226507

ACTIVE NOT RECRUITING 43 participants

Assessment of Paclitaxel-Induced Neuropathy

University of Chicago

NCT01953159

ACTIVE NOT RECRUITING Phase 1 40 participants

Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers

Arcus Biosciences

NCT05891171

ACTIVE NOT RECRUITING Phase 2 35 participants

Bevacizumab in Ovarian Cancer Patients With Disease at Second-Look Surgery

M.D. Anderson Cancer Center

NCT02884648

ACTIVE NOT RECRUITING NA 30 participants

Journey Ahead: Enhancing Coping and Communication for Women Diagnosed With Gynecological Cancer

Rutgers, The State University of New Jersey

NCT05220033

ACTIVE NOT RECRUITING 24 participants

Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer

Abramson Cancer Center at Penn Medicine

NCT06436248

ACTIVE NOT RECRUITING Phase 2 23 participants

Vaccination of Patients With Ovarian Cancer With Dendritic Cell/Tumor Fusions With Granulocyte Macrophage Colony-stimulating Factor (GM-CSF) and Imiquimod

Beth Israel Deaconess Medical Center

NCT00799110

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Phase Distribution

PhaseTrial count
Phase 1 143
Phase 2 87
Phase 3 25
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Ovarian Cancer Trial Landscape

338 indexed Ovarian Cancer studies · 147 recruiting (43%).

Phase mix: 28 late (III/IV) vs 230 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (31 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Ovarian Cancer?

PlainTrial tracks 338 US clinical trials for Ovarian Cancer, of which 147 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Ovarian Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.