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ACTIVE NOT RECRUITING Phase 3

Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing

NCT05059522 · View on ClinicalTrials.gov ↗

Study Summary

This Master Protocol for Avelumab Continuation Sub-Studies is to provide continued treatment access, safety follow-up, and when applicable, overall survival follow-up for eligible participants who continue to derive a benefit from study intervention in the Pfizer-sponsored Avelumab parent studies.

Interventions

  • DRUG Pemetrexed
  • DRUG Talazoparib
  • DRUG Axitinib
  • DRUG Avelumab
  • DRUG Lorlatanib

Study Locations (20)

New York

  • MSK Commack — Commack
  • MSK Westchester — Harrison
  • Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street). — New York
  • Memorial Sloan Kettering Cancer Center 53rd street. — New York
  • Memorial Sloan Kettering Cancer Center — New York
  • MSK Nassau — Uniondale

Arkansas

  • Highlands Oncology Group, PA — Fayetteville
  • Highlands Oncology Group, PA — Rogers
  • Highlands Oncology Group, PA — Springdale

New Jersey

  • MSK Basking Ridge — Basking Ridge
  • MSK Monmouth — Middletown
  • MSK Bergen — Montvale

New South Wales

  • Macquarie University — North Ryde
  • Mater Hospital Sydney — Wollstonecraft
  • Melanoma Institute Australia — Wollstonecraft

California

  • UCLA Hematology/Oncology — Los Angeles

Florida

  • Moffitt Cancer Center — Tampa

Pennsylvania

  • Hospital of the University of Pennsylvania — Philadelphia

Texas

  • The University of Texas MD Anderson Cancer Center — Houston

Trial Details

FieldValue
Enrollment Target 68 participants
Start Date 2021-09-29
Est. Completion 2026-09-30
Phase Phase 3

Sponsor

Pfizer

769 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05059522

The ClinicalTrials.gov registry entry for NCT05059522 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 68 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 5 conditions, with Ovarian Cancer appearing as the primary indexed condition, and to 5 interventions — of which Pemetrexed is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05059522 reports 20 study locations spanning 9 distinct geographic areas — top geographies include New York, Arkansas, New Jersey. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05059522 about?

NCT05059522 is a clinical study titled "Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing". This Master Protocol for Avelumab Continuation Sub-Studies is to provide continued treatment access, safety follow-up, and when applicable, overall survival follow-up for eligible participants who continue to derive a benefit from study intervention in the Pfizer-sponsored Avelumab parent studies.

What is the current status of trial NCT05059522?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 68 participants. The study started on 2021-09-29. Estimated completion is 2026-09-30.

What conditions does trial NCT05059522 study?

This clinical trial studies the following conditions: Ovarian Cancer, Solid Tumors, NSCLC, Urothelial Cancer, Advanced Malignancies. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05059522?

The interventions under investigation include: Pemetrexed (DRUG), Talazoparib (DRUG), Axitinib (DRUG), Avelumab (DRUG), Lorlatanib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05059522?

This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05059522 being conducted?

This trial has 20 study locations across Arkansas, California, Florida, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial