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Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
NCT04644068 · View on ClinicalTrials.gov ↗
Study Summary
This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors.
Conditions Studied
Interventions
- DRUG Carboplatin
- DRUG Paclitaxel
- DRUG Dato-DXd
- DRUG AZD5305
- DRUG T- Dxd
Study Locations (20)
Other
- Research Site — Heidelberg
- Research Site — Melbourne
- Research Site — Beijing
- Research Site — Changchun
- Research Site — Changsha
- Research Site — Chengdu
- Research Site — Chongqing
- Research Site — Guangzhou
- Research Site — Harbin
- Research Site — Jining
- Research Site — Shandong
Massachusetts
- Research Site — Boston
- Research Site — Boston
Quebec
- Research Site — Montreal
- Research Site — Montreal
New York
- Research Site — New York
Oklahoma
- Research Site — Oklahoma City
Texas
- Research Site — Houston
British Columbia
- Research Site — Vancouver
Ontario
- Research Site — Toronto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 702 participants |
| Start Date | 2020-11-12 |
| Est. Completion | 2027-05-28 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04644068
The ClinicalTrials.gov registry entry for NCT04644068 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 702 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 10 conditions, with Breast Cancer appearing as the primary indexed condition, and to 5 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04644068 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Other, Massachusetts, Quebec. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04644068 about?
NCT04644068 is a clinical study titled "Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies". This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors.
What is the current status of trial NCT04644068?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 702 participants. The study started on 2020-11-12. Estimated completion is 2027-05-28.
What conditions does trial NCT04644068 study?
This clinical trial studies the following conditions: Breast Cancer, Prostate Cancer, Colorectal Cancer, Ovarian Cancer, Pancreatic Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04644068?
The interventions under investigation include: Carboplatin (DRUG), Paclitaxel (DRUG), Dato-DXd (DRUG), AZD5305 (DRUG), T- Dxd (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04644068?
This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04644068 being conducted?
This trial has 20 study locations across Massachusetts, New York, Oklahoma, Texas, British Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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