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ACTIVE NOT RECRUITING Phase 2

A Study of XmAb20717 (Vudalimab)in Patients With Selected Advanced Gynecologic and Genitourinary Malignancies

NCT05032040 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase 2, multicenter, two-stage, open-label, parallel-group study designed to evaluate the efficacy and safety of vudalimab (XmAb20717) in patients with selected advanced gynecologic and genitourinary malignancies.

Interventions

  • BIOLOGICAL vudalimab

Study Locations (17)

California

  • UCSD Moores Cancer Center — La Jolla
  • Valkyrie Clinical Trials — Los Angeles
  • UCLA Medical Center — Los Angeles
  • Kaiser Permanente Medical Group — Riverside
  • UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco

New York

  • NYU Langone Health — New York
  • Columbia University Medical Center — New York

Arizona

  • Arizona Oncology Associates, PC - NAHOA — Prescott

Colorado

  • Rocky Mountain Cancer Centers — Aurora

Delaware

  • Medical Oncology Hematology Consultants, PA — Newark

Florida

  • Moffitt Cancer Center — Tampa

Georgia

  • Winship Cancer Institute, Emory University — Atlanta

Michigan

  • Karmanos Cancer Institute — Detroit

Trial Details

FieldValue
Enrollment Target 170 participants
Start Date 2022-07-21
Est. Completion 2025-12-30
Phase Phase 2

Sponsor

Xencor

7 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05032040

The ClinicalTrials.gov registry entry for NCT05032040 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 170 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Xencor, which has 7 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 5 conditions, with Ovarian Cancer appearing as the primary indexed condition, and to 1 intervention — of which vudalimab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05032040 reports 17 study locations spanning 12 distinct geographic areas — top geographies include California, New York, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05032040 about?

NCT05032040 is a clinical study titled "A Study of XmAb20717 (Vudalimab)in Patients With Selected Advanced Gynecologic and Genitourinary Malignancies". This is a Phase 2, multicenter, two-stage, open-label, parallel-group study designed to evaluate the efficacy and safety of vudalimab (XmAb20717) in patients with selected advanced gynecologic and genitourinary malignancies.

What is the current status of trial NCT05032040?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 170 participants. The study started on 2022-07-21. Estimated completion is 2025-12-30.

What conditions does trial NCT05032040 study?

This clinical trial studies the following conditions: Ovarian Cancer, Endometrial Cancer, Cervical Carcinoma, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Clear Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05032040?

The interventions under investigation include: vudalimab (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05032040?

This trial is sponsored by Xencor, which has 7 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05032040 being conducted?

This trial has 17 study locations across Arizona, California, Colorado, Delaware, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial