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ACTIVE NOT RECRUITING Phase 1

MAGE-A4ᶜ¹º³²T for Multi-Tumor

NCT03132922 · View on ClinicalTrials.gov ↗

Study Summary

This study will investigate the safety and tolerability of MAGE-A4ᶜ¹º³²T cell therapy in subjects who have the appropriate HLA-A2 tissue marker and whose urinary bladder, melanoma, head and neck, ovarian, non-small cell lung, esophageal, gastric, synovial sarcoma, or myxoid/round call liposarcoma (MRCLS) tumor has the MAGE-A4 protein expressed. This study will take a subject's T cells and give them a T cell receptor protein that recognizes and attacks the tumors. This study has a substudy component that will investigate the safety and tolerability of MAGE-A4c1032T cell therapy in combination with low dose radiation in up to 10 subjects.

Interventions

  • GENETIC Autologous genetically modified MAGE-A4ᶜ¹º³²T cells
  • RADIATION Autologous genetically modified MAGE-A4c1032T cells combined with low dose radiation

Study Locations (11)

Florida

  • University of Miami — Miami
  • Moffitt Cancer Center — Tampa

Missouri

  • Washington University School of Medicine — St Louis
  • Washington University — St Louis

New York

  • Roswell Park Cancer Institute — Buffalo

North Carolina

  • Duke University Medical Center, Duke Cancer Institute — Durham

Ohio

  • Ohio State University Wexner Medical Center — Columbus

Pennsylvania

  • Fox Chase Cancer Center — Philadelphia

Tennessee

  • Tennessee Oncology - Sarah Cannon Research Institute — Nashville

Texas

  • M.D. Anderson Cancer Center — Houston

Trial Details

FieldValue
Enrollment Target 71 participants
Start Date 2017-05-15
Est. Completion 2032-09
Phase Phase 1

Sponsor

Adaptimmune

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03132922

The ClinicalTrials.gov registry entry for NCT03132922 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 71 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Adaptimmune, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Ovarian Cancer appearing as the primary indexed condition, and to 2 interventions — of which Autologous genetically modified MAGE-A4ᶜ¹º³²T cells is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03132922 reports 11 study locations spanning 9 distinct geographic areas — top geographies include Florida, Missouri, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03132922 about?

NCT03132922 is a clinical study titled "MAGE-A4ᶜ¹º³²T for Multi-Tumor". This study will investigate the safety and tolerability of MAGE-A4ᶜ¹º³²T cell therapy in subjects who have the appropriate HLA-A2 tissue marker and whose urinary bladder, melanoma, head and neck, ovarian, non-small cell lung, esophageal, gastric, synovial sarcoma, or myxoid/round call liposarcoma (M...

What is the current status of trial NCT03132922?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 71 participants. The study started on 2017-05-15. Estimated completion is 2032-09.

What conditions does trial NCT03132922 study?

This clinical trial studies the following conditions: Ovarian Cancer, Melanoma, Head and Neck Cancer, Gastric Cancer, Non-Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03132922?

The interventions under investigation include: Autologous genetically modified MAGE-A4ᶜ¹º³²T cells (GENETIC), Autologous genetically modified MAGE-A4c1032T cells combined with low dose radiation (RADIATION). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03132922?

This trial is sponsored by Adaptimmune, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03132922 being conducted?

This trial has 11 study locations across Florida, Missouri, New York, North Carolina, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial