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Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302)
NCT06433219 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to measure the effect and safety of treatment with tuvusertib combined with either niraparib or lartesertib in participants with epithelial ovarian cancer and to assess any differences between tuvusertib monotherapy and combination therapy. The participants will previously have progressed while treated with a poly ADP ribose polymerase (PARP) inhibitor. The primary objectives of this study are to assess the effect of the treatment in terms of overall response, i.e. whether the tumor disappears, shrinks, remains unchanged, or gets worse and safety in terms of adverse events.
Conditions Studied
Interventions
- DRUG Niraparib
- DRUG Tuvusertib (M1774)
- DRUG Lartesertib (M4076)
Study Locations (20)
Other
- Chris O'Brien Lifehouse — Camperdown
- St George Private Hospital — Kogarah
- Liverpool Hospital - PARENT — Liverpool
- Cliniques Universitaires Saint-Luc - STL — Brussels
- UZ Leuven — Leuven
- Ålborg Universitets Hospital - PARENT — Aalborg
- Rigshospitalet — Copenhagen
- Sjaellands Universitetshospital - other — Odense
- ICO - Site Paul Papin - service d'oncologie medicale — Angers
- Centre Francois Baclesse - Service d'Oncologie Medicale — Caen
- Centre Oscar Lambret - service de cancerologie gynecologique — Lille
New York
- Memorial Sloan Kettering Cancer Center — New York
- Icahn School of Medicine at Mount Sinai PRIME - Mount Sinai - PRIME — New York
Virginia
- Next Oncology - Virginia — Fairfax
- Virginia Cancer Specialists, PC — Fairfax
Arkansas
- University of Arkansas for Medical Sciences — Little Rock
California
- University of California San Francisco - UCSF Medical Center — San Francisco
Georgia
- Centricity Research Cancer Center - DBA CRRI John B. Amos Cancer Center Research — Columbus
Illinois
- University of Chicago Comprehensive Cancer Center at Silver Cross - Carolyn J. Czerkies Pavilion — Chicago
Michigan
- University of Michigan Rogel Cancer Center — Ann Arbor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 63 participants |
| Start Date | 2024-10-30 |
| Est. Completion | 2026-06-26 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06433219
The ClinicalTrials.gov registry entry for NCT06433219 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 63 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is EMD Serono Research & Development Institute, which has 51 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Ovarian Cancer appearing as the primary indexed condition, and to 3 interventions — of which Niraparib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06433219 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Other, New York, Virginia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06433219 about?
NCT06433219 is a clinical study titled "Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302)". The purpose of this study is to measure the effect and safety of treatment with tuvusertib combined with either niraparib or lartesertib in participants with epithelial ovarian cancer and to assess any differences between tuvusertib monotherapy and combination therapy. The participants will previous...
What is the current status of trial NCT06433219?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 63 participants. The study started on 2024-10-30. Estimated completion is 2026-06-26.
What conditions does trial NCT06433219 study?
This clinical trial studies the following conditions: Ovarian Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06433219?
The interventions under investigation include: Niraparib (DRUG), Tuvusertib (M1774) (DRUG), Lartesertib (M4076) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06433219?
This trial is sponsored by EMD Serono Research & Development Institute, which has 51 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06433219 being conducted?
This trial has 20 study locations across Arkansas, California, Georgia, Illinois, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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