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ACTIVE NOT RECRUITING Phase 1

P-MUC1C-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Advanced or Metastatic Solid Tumors

NCT05239143 · View on ClinicalTrials.gov ↗

Study Summary

A Phase 1, open label, dose escalation and expanded cohort study of P-MUC1C-ALLO1 in adult subjects with advanced or metastatic epithelial derived solid tumors, including but not limited to the tumor types listed below.

Interventions

  • DRUG Rimiducid
  • BIOLOGICAL P-MUC1C-ALLO1 CAR-T cells

Study Locations (14)

California

  • University of California, Irvine Medical Center — Irvine
  • Cedars Sinai Medical Center — Los Angeles
  • University of California, San Diego — San Diego
  • University of California, San Francisco — San Francisco

Kansas

  • University of Kansas Cancer Center — Westwood
  • Cancer Center of Kansas — Wichita

Texas

  • MD Anderson Cancer Center — Houston
  • NEXT Oncology — San Antonio

Colorado

  • Sarah Cannon Research Institute at HealthONE — Denver

Iowa

  • University of Iowa Hospitals and Clinics — Iowa City

Maryland

  • University of Maryland Cancer Center — Baltimore

Massachusetts

  • Dana Farber Cancer Institute — Boston

Nebraska

  • University of Nebraska Medical Center — Omaha

Trial Details

FieldValue
Enrollment Target 180 participants
Start Date 2022-02-15
Est. Completion 2039-04
Phase Phase 1

Sponsor

Poseida Therapeutics

4 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05239143

The ClinicalTrials.gov registry entry for NCT05239143 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Poseida Therapeutics, which has 4 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 9 conditions, with Breast Cancer appearing as the primary indexed condition, and to 2 interventions — of which Rimiducid is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05239143 reports 14 study locations spanning 9 distinct geographic areas — top geographies include California, Kansas, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05239143 about?

NCT05239143 is a clinical study titled "P-MUC1C-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Advanced or Metastatic Solid Tumors". A Phase 1, open label, dose escalation and expanded cohort study of P-MUC1C-ALLO1 in adult subjects with advanced or metastatic epithelial derived solid tumors, including but not limited to the tumor types listed below.

What is the current status of trial NCT05239143?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 180 participants. The study started on 2022-02-15. Estimated completion is 2039-04.

What conditions does trial NCT05239143 study?

This clinical trial studies the following conditions: Breast Cancer, Colorectal Cancer, Ovarian Cancer, Pancreatic Cancer, Gastric Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05239143?

The interventions under investigation include: Rimiducid (DRUG), P-MUC1C-ALLO1 CAR-T cells (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05239143?

This trial is sponsored by Poseida Therapeutics, which has 4 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05239143 being conducted?

This trial has 14 study locations across California, Colorado, Iowa, Kansas, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial