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ClinicalTrials.gov 58 recruiting now official registry

Diabetes Mellitus, Type 2 clinical trials

Every US clinical trial registered for Diabetes Mellitus, Type 2 — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

328 US clinical trials · 58 currently recruiting

The research picture

Diabetes Mellitus, Type 2 has 328 registered US clinical trials, 58 of them open to new participants right now — about 18% of the total.

58
recruiting participants now
18%
of trials open to enrollment
96
in Phase 3–4 (later-stage)
48
top sponsor: Novo Nordisk A/S

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 119,680 participants

Implementing Scalable, PAtient-centered, Team-based, Technology-enabled Care for Adults With Type 2 Diabetes (iPATH)

Stanford University

NCT06251323

RECRUITING Phase 3 11,800 participants

EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

Boehringer Ingelheim

NCT07064473

RECRUITING NA 7,500 participants

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

Cleerly

NCT06112418

RECRUITING 1,250 participants

Blood Markers of Early Pancreas Cancer

University of Nebraska

NCT03568630

RECRUITING NA 900 participants

Improving Diabetes Care With Strategies For Addressing Health-Related Social Needs and Community Partnerships

Boston Medical Center

NCT07043426

RECRUITING NA 840 participants

Promoting Preconception Care and Diabetes Self-Management Among Reproductive-Aged Women With Diabetes

Northwestern University

NCT04976881

RECRUITING NA 700 participants

Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)

The University of Texas Health Science Center at San Antonio

NCT02969798

RECRUITING NA 568 participants

Linking Education, Produce Provision, and Community Referrals to Improve Diabetes Care (LINK)

Ohio State University

NCT05472441

RECRUITING NA 500 participants

Improving the Collaborative Health of Minority COVID-19 Survivor and Carepartner Dyads

University of South Carolina

NCT05370014

RECRUITING NA 400 participants

Healthy Communities Through CHW Initiatives

The University of Texas Medical Branch, Galveston

NCT05965869

RECRUITING NA 360 participants

Safer Aging With Diabetes Monitoring

Kaiser Permanente

NCT06296485

RECRUITING Phase 2 336 participants

DETERMINE: Detemir vs NPH

University of California, Los Angeles

NCT05124457

RECRUITING 330 participants

Mixed Methods Study of Health-Related Social Needs in African American Adults With Chronic Kidney Disease and Type 2 Diabetes Mellitus

Medical College of Wisconsin

NCT05692388

RECRUITING NA 300 participants

Sleep for Health Study on the Effects of Cognitive Behavioral Therapy for Insomnia on Diabetes Risk

Kaiser Permanente

NCT06067139

RECRUITING Phase 4 300 participants

Effect of Continuing Versus Holding Metformin During Hospitalizations.

University of Illinois at Chicago

NCT06296836

RECRUITING NA 288 participants

Family Model DSME in FBOs in the RMI

University of Arkansas

NCT05502016

RECRUITING NA 280 participants

Boosting Emotional Well-being and Happiness in Outpatients Living With Diabetes

Massachusetts General Hospital

NCT05420051

RECRUITING NA 264 participants

Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals With Type II Diabetes

Endogenex

NCT06267391

RECRUITING NA 204 participants

Care Navigator Support for Younger Latinx Adults With Type 2 Diabetes

Kaiser Permanente

NCT05754008

RECRUITING NA 200 participants

Food as Medicine for HIV and Diabetes

University of North Carolina, Chapel Hill

NCT05026723

RECRUITING Phase 2 200 participants

A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

Eli Lilly and Company

NCT07215559

RECRUITING 200 participants

Transformative Research in Diabetic Nephropathy 2.0

University of Pennsylvania

NCT07444203

RECRUITING NA 160 participants

Food Insecurity Reduction & Strategy Team

Stanford University

NCT06329375

RECRUITING 150 participants

Drug Interaction Potential of Pro-Inflammatory Conditions

Indiana University

NCT07360938

RECRUITING NA 150 participants

Strategies to Improve Well-Being and Diabetes Management

Elizabeth Scharnetzki

NCT06348238

RECRUITING NA 128 participants

Diabetes Learning in Virtual Environments Just in Time for Community Reentry

Louise Reagan

NCT05286892

RECRUITING NA 120 participants

Diabetes Toolkit at Discharge

Northwestern University

NCT05663931

RECRUITING Phase 4 120 participants

Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes

University of Kansas Medical Center

NCT06478186

RECRUITING NA 110 participants

Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance

Stanford University

NCT05165706

RECRUITING NA 100 participants

Phenotyping Genetic Risk for Type 2 Diabetes

University of Pennsylvania

NCT04024631

RECRUITING Phase 2 100 participants

MANAGe-DM: Novel Nurse Case Management to Improve Diabetes Outcomes in Formerly Incarcerated Black Men

Medical College of Wisconsin

NCT06031428

RECRUITING NA 100 participants

Post Prandial Individual Responses to Different Foods

Stanford University

NCT06989164

RECRUITING Phase 2 100 participants

A Study of LY3938577 in Participants With Type 2 Diabetes Previously Treated With Basal Insulin

Eli Lilly and Company

NCT07215312

RECRUITING NA 80 participants

Gemini Study: A Prospective, Multicenter Evaluation of Performance and Safety of the Eversense Gemini System With Flash Glucose Measurement Feature

Senseonics

NCT07386340

RECRUITING NA 80 participants

Michigan Men's Diabetes Project III(MenDIII): Mind and Motion

University of Michigan

NCT06574035

RECRUITING NA 80 participants

Use of CGM in Kidney Transplant Recipients

University of California, Davis

NCT04783441

RECRUITING NA 76 participants

OASIS: Peer Support for T2DM in Appalachia (Peer Participant)

University of Kentucky

NCT06336122

RECRUITING NA 75 participants

Promoting Intergenerational Health in Rural Kentuckians With Diabetes (PIHRK'D)

The University of Texas Medical Branch, Galveston

NCT06080425

RECRUITING NA 65 participants

Impact of a Diabetes Education Mobile Web Application on Patients With Uncontrolled Type 2 Diabetes

The Reading Hospital and Medical Center

NCT05893927

RECRUITING Phase 1 64 participants

Multiple Dose Study of MK-2828 in Participants With Type 2 Diabetes (MK-2828-003)

Merck Sharp & Dohme

NCT07089784

RECRUITING 60 participants

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

Bettina Mittendorfer

NCT06571474

RECRUITING NA 60 participants

Time-Restricted Eating for Type II Diabetes: TRE-T2D

University of California, San Diego

NCT05365529

RECRUITING NA 60 participants

In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes

Cornell University

NCT06557317

RECRUITING Phase 1 52 participants

A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006)

Merck Sharp & Dohme

NCT07242469

RECRUITING NA 50 participants

Continuous Glucose Metrics in Patients With Gastroparesis in Type 1 or Type 2 Diabetes

Samita Garg

NCT06046833

RECRUITING Phase 4 50 participants

Effects of Semaglutide on Intracranial Blood Flow and Brain-Barrier Permeability in Type-2 Diabetes

University of Washington

NCT05780905

RECRUITING NA 48 participants

Project Dulce for Arab Americans With Type 2 Diabetes

Scripps Whittier Diabetes Institute

NCT05580536

RECRUITING NA 48 participants

Assessing the Value of Avocados on Glycemic Control in Type 2 Diabetes

Pennington Biomedical Research Center

NCT05958368

RECRUITING NA 45 participants

Efficacy of mHealth Apps for Health in a Low-income, Type II Diabetic, Hispanic Population

San Diego State University

NCT05279729

RECRUITING NA 30 participants

Trial to Assess Continuous Glucose Monitoring in Asian Americans With Type 2 Diabetes

Joslin Diabetes Center

NCT05826678

RECRUITING NA 30 participants

Efficacy of Using Mobile Health Applications for Health

San Diego State University

NCT05589155

RECRUITING NA 30 participants

Pilot-Testing Real-Time Engagement for Learning to Effectively Control Type 2 Diabetes

University of Pittsburgh

NCT07270016

RECRUITING NA 30 participants

Exercise and Time of Day in Type 2 Diabetes

Rutgers, The State University of New Jersey

NCT05108987

RECRUITING 30 participants

Improvement of Hyperglycemia/Diabetes in Patients to Improve Safety

Northwestern University

NCT06096311

RECRUITING NA 25 participants

OASIS: Peer Support for T2DM in Appalachia (Peer Coaches)

Brittany L Smalls

NCT06003634

RECRUITING NA 24 participants

Reversibility of Brain Glucose Transport in Type 2 Diabetes Mellitus (T2DM)

Yale University

NCT05776563

RECRUITING NA 20 participants

The Acute T-Rex (Timing of Resistance Exercise) Study

University of Utah

NCT06366399

RECRUITING NA 15 participants

SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease

University of Nebraska

NCT06480786

ACTIVE NOT RECRUITING 230,000 participants

Comparative Effectiveness of Empagliflozin in the US

Boehringer Ingelheim

NCT03363464

ACTIVE NOT RECRUITING NA 20,000 participants

Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)

Signos

NCT05874635

ACTIVE NOT RECRUITING NA 10,120 participants

Weight Loss Clinical Decision Support

HealthPartners Institute

NCT05198765

ACTIVE NOT RECRUITING Phase 3 1,500 participants

A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes

Novo Nordisk A/S

NCT03811561

ACTIVE NOT RECRUITING Phase 3 1,250 participants

Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)

Eli Lilly and Company

NCT06260722

ACTIVE NOT RECRUITING Phase 1 1,033 participants

Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans

Massachusetts General Hospital

NCT01762046

ACTIVE NOT RECRUITING Phase 3 1,023 participants

A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both

Novo Nordisk A/S

NCT06534411

ACTIVE NOT RECRUITING NA 1,007 participants

Kaiser Permanente Evaluating Nutritional Interventions in Food-Insecure High-Risk Adults Study

Kaiser Permanente

NCT06061861

ACTIVE NOT RECRUITING Phase 3 755 participants

A Study to Test Whether Survodutide (BI 456906) Helps People Living With Overweight or Obesity Who Also Have Diabetes to Lose Weight

Boehringer Ingelheim

NCT06066528

ACTIVE NOT RECRUITING 750 participants

Integrating Abbott Point-of-Care Technologies and the Community Scientist Model to Support HbA1c Testing Per ADA

Sansum Diabetes Research Institute

NCT05000840

ACTIVE NOT RECRUITING 500 participants

Biological Sample Repository for Gastrointestinal Disorders

Pichamol Jirapinyo, MD, MPH

NCT05874726

ACTIVE NOT RECRUITING Phase 2 473 participants

Addressing Basic Needs to Improve Diabetes Outcomes in Medicaid Beneficiaries

Washington University School of Medicine

NCT03940209

ACTIVE NOT RECRUITING NA 378 participants

Decreasing Cardiovascular Risk for Patients With Diabetes

Michigan State University

NCT04874116

ACTIVE NOT RECRUITING NA 360 participants

Glucose Monitoring Comparison in Primary Care

HealthPartners Institute

NCT05222815

ACTIVE NOT RECRUITING NA 352 participants

Promoting Successful Weight Loss in Primary Care in Louisiana Using Information Technology

Pennington Biomedical Research Center

NCT05523375

ACTIVE NOT RECRUITING NA 344 participants

Using Early Time Restricted Feeding and Timed Light Therapy to Improve Glycemic Control in Adults With Type 2 Diabetes

University of Alabama at Birmingham

NCT04155619

ACTIVE NOT RECRUITING NA 320 participants

Evaluating Telementoring for CHW-centered Diabetes Initiatives

The University of Texas Medical Branch, Galveston

NCT04835493

ACTIVE NOT RECRUITING NA 310 participants

A Shared Decision Making Intervention for Diabetes Prevention in Women With a History of Gestational Diabetes Mellitus

University of California, Los Angeles

NCT04897945

ACTIVE NOT RECRUITING NA 304 participants

Food Delivery, Remote Monitoring, and Coaching-Enhanced Education for Optimized Diabetes Management (FREEDOM)

University of Alabama at Birmingham

NCT05288452

ACTIVE NOT RECRUITING NA 218 participants

Continuous Glucose Monitoring Devices in Hospitalized Veterans With Diabetes

VA Office of Research and Development

NCT03508934

ACTIVE NOT RECRUITING Phase 1 208 participants

A Family Dyad-focused Diabetes Self-Management Intervention for African American Adults

Ohio State University

NCT05905575

ACTIVE NOT RECRUITING NA 200 participants

Food As MedicinE for Diabetes

University of North Carolina, Chapel Hill

NCT04828785

ACTIVE NOT RECRUITING NA 198 participants

The Dietary Guidelines 3 Diet Patterns Study (DG3D): Phase 2

University of South Carolina

NCT05254496

ACTIVE NOT RECRUITING 172 participants

The HIV, Adipose Tissue Immunology, and Metabolism Study

Vanderbilt University Medical Center

NCT04451980

ACTIVE NOT RECRUITING NA 150 participants

Lowering Food Insecurity and Improving Diabetes With Financial Incentives

State University of New York at Buffalo

NCT05352022

ACTIVE NOT RECRUITING Phase 2 142 participants

A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy

Novo Nordisk A/S

NCT06797869

ACTIVE NOT RECRUITING NA 120 participants

Diabetes Discharge Transitional CGM Study (DDT-CGM)

Intermountain Health Care

NCT04729985

ACTIVE NOT RECRUITING Phase 2 120 participants

Glycemic Control After Antenatal Corticosteroids in Women With Pregestational and Gestational Diabetes

University of Alabama at Birmingham

NCT04542148

ACTIVE NOT RECRUITING NA 100 participants

Precision Diets for Diabetes Prevention

Stanford University

NCT03919877

ACTIVE NOT RECRUITING NA 100 participants

Mastering Diabetes Study

Ohio University

NCT04454957

ACTIVE NOT RECRUITING Phase 4 88 participants

Surgical or Medical Treatment

Children's Hospital Medical Center, Cincinnati

NCT04128995

ACTIVE NOT RECRUITING NA 60 participants

Electronic Diabetes Tune-Up Group (eDTU) for African Americans

Indiana University

NCT06321029

ACTIVE NOT RECRUITING Phase 1 49 participants

Study of Subcutaneously Administered ENT-03 for the Treatment of Obesity and Diabetes

Metabolics Pharma

NCT05925920

ACTIVE NOT RECRUITING NA 48 participants

Michigan Men's Diabetes Project 2

University of Michigan

NCT05370781

ACTIVE NOT RECRUITING 46 participants

Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans

University of Pittsburgh

NCT02710370

ACTIVE NOT RECRUITING 40 participants

Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics

Washington University School of Medicine

NCT03348280

ACTIVE NOT RECRUITING NA 40 participants

Self-Management and Glycemic Control in Adult Haitian Immigrants With Type 2 Diabetes

New York University

NCT04949568

ACTIVE NOT RECRUITING Phase 2 40 participants

MN-001 in Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus, and Hypertriglyceridemia

MediciNova

NCT05464784

ACTIVE NOT RECRUITING NA 40 participants

Short Interval Resveratrol Trial in Cardiovascular Surgery

MaineHealth

NCT03762096

ACTIVE NOT RECRUITING NA 36 participants

ADAM17 and Vascular Function in Diabetes

University of Missouri-Columbia

NCT04557228

ACTIVE NOT RECRUITING 32 participants

CGM Monitoring in T2DM Patients Undergoing Orthopaedic Replacement Surgery

Stony Brook University

NCT05666479

COMPLETED 714,582 participants

A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease

Janssen Research & Development

NCT03492580

Phase Distribution

PhaseTrial count
Phase 1 36
Phase 2 35
Phase 3 70
Phase 4 26

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diabetes Mellitus, Type 2 Trial Landscape

ClinicalTrials.gov lists 328 US studies indexed under Diabetes Mellitus, Type 2, and 58 of those are currently open to recruitment — roughly 18% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Diabetes Mellitus, Type 2 shows 96 late-stage studies (Phase 3 and Phase 4 combined) alongside 71 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Diabetes Mellitus, Type 2 is led by Novo Nordisk A/S with 48 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diabetes Mellitus, Type 2?

PlainTrial tracks 328 US clinical trials for Diabetes Mellitus, Type 2, of which 58 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diabetes Mellitus, Type 2?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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