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ClinicalTrials.gov 63 recruiting now official registry

Diabetes Mellitus, Type 2 clinical trials

63 of 351 indexed Diabetes Mellitus, Type 2 trials are currently recruiting.

351 US clinical trials · 63 currently recruiting

Diabetes Mellitus, Type 2 is the subject of 351 registered US clinical trials on ClinicalTrials.gov, 63 of them currently open to new participants. 100 are in Phase 3-4 (later-stage) and 80 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 48 of these trials.

The research picture

Diabetes Mellitus, Type 2 has 351 registered US clinical trials, 63 of them open to new participants right now, about 18% of the total.

63
recruiting participants now
18%
of trials open to enrollment
100
in Phase 3–4 (later-stage)
48
top sponsor: Novo Nordisk A/S
Phase 142Phase 238Phase 374Phase 426

Active & Recent Trials

351 total, page 1 of 8

RECRUITING NA 119,680 participants

Implementing Scalable, PAtient-centered, Team-based, Technology-enabled Care for Adults With Type 2 Diabetes (iPATH)

Stanford University

NCT06251323

RECRUITING Phase 3 11,800 participants

EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

Boehringer Ingelheim

NCT07064473

RECRUITING NA 7,500 participants

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

Cleerly

NCT06112418

RECRUITING 1,250 participants

Blood Markers of Early Pancreas Cancer

University of Nebraska

NCT03568630

RECRUITING NA 900 participants

Improving Diabetes Care With Strategies For Addressing Health-Related Social Needs and Community Partnerships

Boston Medical Center

NCT07043426

RECRUITING NA 840 participants

Promoting Preconception Care and Diabetes Self-Management Among Reproductive-Aged Women With Diabetes

Northwestern University

NCT04976881

RECRUITING NA 700 participants

Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)

The University of Texas Health Science Center at San Antonio

NCT02969798

RECRUITING NA 568 participants

Linking Education, Produce Provision, and Community Referrals to Improve Diabetes Care (LINK)

Ohio State University

NCT05472441

RECRUITING NA 500 participants

Improving the Collaborative Health of Minority COVID-19 Survivor and Carepartner Dyads

University of South Carolina

NCT05370014

RECRUITING NA 400 participants

Healthy Communities Through CHW Initiatives

The University of Texas Medical Branch, Galveston

NCT05965869

RECRUITING NA 360 participants

Safer Aging With Diabetes Monitoring

Kaiser Permanente

NCT06296485

RECRUITING Phase 2 336 participants

DETERMINE: Detemir vs NPH

University of California, Los Angeles

NCT05124457

RECRUITING 330 participants

Mixed Methods Study of Health-Related Social Needs in African American Adults With Chronic Kidney Disease and Type 2 Diabetes Mellitus

Medical College of Wisconsin

NCT05692388

RECRUITING NA 318 participants

Increasing CGM Use Among Patients With T2D

San Diego State University

NCT06638099

RECRUITING NA 300 participants

Sleep for Health Study on the Effects of Cognitive Behavioral Therapy for Insomnia on Diabetes Risk

Kaiser Permanente

NCT06067139

RECRUITING Phase 4 300 participants

Effect of Continuing Versus Holding Metformin During Hospitalizations.

University of Illinois at Chicago

NCT06296836

RECRUITING NA 288 participants

Family Model DSME in FBOs in the RMI

University of Arkansas

NCT05502016

RECRUITING NA 280 participants

Boosting Emotional Well-being and Happiness in Outpatients Living With Diabetes

Massachusetts General Hospital

NCT05420051

RECRUITING NA 264 participants

Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals With Type II Diabetes

Endogenex

NCT06267391

RECRUITING NA 240 participants

Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery

University of Colorado, Denver

NCT07011147

RECRUITING NA 204 participants

Care Navigator Support for Younger Latinx Adults With Type 2 Diabetes

Kaiser Permanente

NCT05754008

RECRUITING NA 200 participants

Food as Medicine for HIV and Diabetes

University of North Carolina, Chapel Hill

NCT05026723

RECRUITING Phase 2 200 participants

A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

Eli Lilly and Company

NCT07215559

RECRUITING 200 participants

Transformative Research in Diabetic Nephropathy 2.0

University of Pennsylvania

NCT07444203

RECRUITING 189 participants

PRimary IndividualiZed Evaluation of Cardiovascular Events in Patients With Diabetes Mellitus Using hemoTAG

Aventusoft

NCT06567795

RECRUITING NA 160 participants

Food Insecurity Reduction & Strategy Team

Stanford University

NCT06329375

RECRUITING 150 participants

Drug Interaction Potential of Pro-Inflammatory Conditions

Indiana University

NCT07360938

RECRUITING NA 150 participants

Strategies to Improve Well-Being and Diabetes Management

Elizabeth Scharnetzki

NCT06348238

RECRUITING NA 128 participants

Diabetes Learning in Virtual Environments Just in Time for Community Reentry

Louise Reagan

NCT05286892

RECRUITING NA 120 participants

Diabetes Toolkit at Discharge

Northwestern University

NCT05663931

RECRUITING Phase 4 120 participants

Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes

University of Kansas Medical Center

NCT06478186

RECRUITING NA 120 participants

HOPE Intervention for Fitness

University of California, Irvine

NCT07114822

RECRUITING NA 110 participants

Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance

Stanford University

NCT05165706

RECRUITING NA 100 participants

Phenotyping Genetic Risk for Type 2 Diabetes

University of Pennsylvania

NCT04024631

RECRUITING Phase 2 100 participants

MANAGe-DM: Novel Nurse Case Management to Improve Diabetes Outcomes in Formerly Incarcerated Black Men

Medical College of Wisconsin

NCT06031428

RECRUITING NA 100 participants

Post Prandial Individual Responses to Different Foods

Stanford University

NCT06989164

RECRUITING Phase 2 100 participants

A Study of LY3938577 in Participants With Type 2 Diabetes Previously Treated With Basal Insulin

Eli Lilly and Company

NCT07215312

RECRUITING NA 90 participants

Effects of High-Resistance Inspiratory Muscle Strength Training on Cardiorenal and Vascular Function in Youth and Young Adults With Type 2 Diabetes

Seattle Children's Hospital

NCT06936670

RECRUITING NA 80 participants

Gemini Study: A Prospective, Multicenter Evaluation of Performance and Safety of the Eversense Gemini System With Flash Glucose Measurement Feature

Senseonics

NCT07386340

RECRUITING NA 80 participants

Michigan Men's Diabetes Project III(MenDIII): Mind and Motion

University of Michigan

NCT06574035

RECRUITING NA 80 participants

Use of CGM in Kidney Transplant Recipients

University of California, Davis

NCT04783441

RECRUITING NA 76 participants

OASIS: Peer Support for T2DM in Appalachia (Peer Participant)

University of Kentucky

NCT06336122

RECRUITING NA 75 participants

Promoting Intergenerational Health in Rural Kentuckians With Diabetes (PIHRK'D)

The University of Texas Medical Branch, Galveston

NCT06080425

RECRUITING NA 65 participants

Impact of a Diabetes Education Mobile Web Application on Patients With Uncontrolled Type 2 Diabetes

The Reading Hospital and Medical Center

NCT05893927

RECRUITING Phase 1 64 participants

Multiple Dose Study of MK-2828 in Participants With Type 2 Diabetes (MK-2828-003)

Merck Sharp & Dohme

NCT07089784

RECRUITING 60 participants

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

Bettina Mittendorfer

NCT06571474

RECRUITING NA 60 participants

Time-Restricted Eating for Type II Diabetes: TRE-T2D

University of California, San Diego

NCT05365529

RECRUITING NA 60 participants

In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes

Cornell University

NCT06557317

RECRUITING Phase 1 52 participants

A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006)

Merck Sharp & Dohme

NCT07242469

RECRUITING NA 50 participants

Continuous Glucose Metrics in Patients With Gastroparesis in Type 1 or Type 2 Diabetes

Samita Garg

NCT06046833

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Phase Distribution

PhaseTrial count
Phase 1 42
Phase 2 38
Phase 3 74
Phase 4 26

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diabetes Mellitus, Type 2 Trial Landscape

351 indexed Diabetes Mellitus, Type 2 studies · 63 recruiting (18%).

Phase mix: 100 late (III/IV) vs 80 early (I/II).

Top sponsor: Novo Nordisk A/S (48 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diabetes Mellitus, Type 2?

PlainTrial tracks 351 US clinical trials for Diabetes Mellitus, Type 2, of which 63 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diabetes Mellitus, Type 2?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.