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Diabetes Mellitus, Type 2 clinical trials
Every US clinical trial registered for Diabetes Mellitus, Type 2 — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
328 US clinical trials · 58 currently recruiting
The research picture
Diabetes Mellitus, Type 2 has 328 registered US clinical trials, 58 of them open to new participants right now — about 18% of the total.
- 58
- recruiting participants now
- 18%
- of trials open to enrollment
- 96
- in Phase 3–4 (later-stage)
- 48
- top sponsor: Novo Nordisk A/S
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Implementing Scalable, PAtient-centered, Team-based, Technology-enabled Care for Adults With Type 2 Diabetes (iPATH)
Stanford University
NCT06251323
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
Boehringer Ingelheim
NCT07064473
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
Cleerly
NCT06112418
Blood Markers of Early Pancreas Cancer
University of Nebraska
NCT03568630
Improving Diabetes Care With Strategies For Addressing Health-Related Social Needs and Community Partnerships
Boston Medical Center
NCT07043426
Promoting Preconception Care and Diabetes Self-Management Among Reproductive-Aged Women With Diabetes
Northwestern University
NCT04976881
Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)
The University of Texas Health Science Center at San Antonio
NCT02969798
Linking Education, Produce Provision, and Community Referrals to Improve Diabetes Care (LINK)
Ohio State University
NCT05472441
Improving the Collaborative Health of Minority COVID-19 Survivor and Carepartner Dyads
University of South Carolina
NCT05370014
Healthy Communities Through CHW Initiatives
The University of Texas Medical Branch, Galveston
NCT05965869
Safer Aging With Diabetes Monitoring
Kaiser Permanente
NCT06296485
DETERMINE: Detemir vs NPH
University of California, Los Angeles
NCT05124457
Mixed Methods Study of Health-Related Social Needs in African American Adults With Chronic Kidney Disease and Type 2 Diabetes Mellitus
Medical College of Wisconsin
NCT05692388
Sleep for Health Study on the Effects of Cognitive Behavioral Therapy for Insomnia on Diabetes Risk
Kaiser Permanente
NCT06067139
Effect of Continuing Versus Holding Metformin During Hospitalizations.
University of Illinois at Chicago
NCT06296836
Family Model DSME in FBOs in the RMI
University of Arkansas
NCT05502016
Boosting Emotional Well-being and Happiness in Outpatients Living With Diabetes
Massachusetts General Hospital
NCT05420051
Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals With Type II Diabetes
Endogenex
NCT06267391
Care Navigator Support for Younger Latinx Adults With Type 2 Diabetes
Kaiser Permanente
NCT05754008
Food as Medicine for HIV and Diabetes
University of North Carolina, Chapel Hill
NCT05026723
A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes
Eli Lilly and Company
NCT07215559
Transformative Research in Diabetic Nephropathy 2.0
University of Pennsylvania
NCT07444203
Food Insecurity Reduction & Strategy Team
Stanford University
NCT06329375
Drug Interaction Potential of Pro-Inflammatory Conditions
Indiana University
NCT07360938
Strategies to Improve Well-Being and Diabetes Management
Elizabeth Scharnetzki
NCT06348238
Diabetes Learning in Virtual Environments Just in Time for Community Reentry
Louise Reagan
NCT05286892
Diabetes Toolkit at Discharge
Northwestern University
NCT05663931
Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes
University of Kansas Medical Center
NCT06478186
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
Stanford University
NCT05165706
Phenotyping Genetic Risk for Type 2 Diabetes
University of Pennsylvania
NCT04024631
MANAGe-DM: Novel Nurse Case Management to Improve Diabetes Outcomes in Formerly Incarcerated Black Men
Medical College of Wisconsin
NCT06031428
Post Prandial Individual Responses to Different Foods
Stanford University
NCT06989164
A Study of LY3938577 in Participants With Type 2 Diabetes Previously Treated With Basal Insulin
Eli Lilly and Company
NCT07215312
Gemini Study: A Prospective, Multicenter Evaluation of Performance and Safety of the Eversense Gemini System With Flash Glucose Measurement Feature
Senseonics
NCT07386340
Michigan Men's Diabetes Project III(MenDIII): Mind and Motion
University of Michigan
NCT06574035
Use of CGM in Kidney Transplant Recipients
University of California, Davis
NCT04783441
OASIS: Peer Support for T2DM in Appalachia (Peer Participant)
University of Kentucky
NCT06336122
Promoting Intergenerational Health in Rural Kentuckians With Diabetes (PIHRK'D)
The University of Texas Medical Branch, Galveston
NCT06080425
Impact of a Diabetes Education Mobile Web Application on Patients With Uncontrolled Type 2 Diabetes
The Reading Hospital and Medical Center
NCT05893927
Multiple Dose Study of MK-2828 in Participants With Type 2 Diabetes (MK-2828-003)
Merck Sharp & Dohme
NCT07089784
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)
Bettina Mittendorfer
NCT06571474
Time-Restricted Eating for Type II Diabetes: TRE-T2D
University of California, San Diego
NCT05365529
In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes
Cornell University
NCT06557317
A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006)
Merck Sharp & Dohme
NCT07242469
Continuous Glucose Metrics in Patients With Gastroparesis in Type 1 or Type 2 Diabetes
Samita Garg
NCT06046833
Effects of Semaglutide on Intracranial Blood Flow and Brain-Barrier Permeability in Type-2 Diabetes
University of Washington
NCT05780905
Project Dulce for Arab Americans With Type 2 Diabetes
Scripps Whittier Diabetes Institute
NCT05580536
Assessing the Value of Avocados on Glycemic Control in Type 2 Diabetes
Pennington Biomedical Research Center
NCT05958368
Efficacy of mHealth Apps for Health in a Low-income, Type II Diabetic, Hispanic Population
San Diego State University
NCT05279729
Trial to Assess Continuous Glucose Monitoring in Asian Americans With Type 2 Diabetes
Joslin Diabetes Center
NCT05826678
Efficacy of Using Mobile Health Applications for Health
San Diego State University
NCT05589155
Pilot-Testing Real-Time Engagement for Learning to Effectively Control Type 2 Diabetes
University of Pittsburgh
NCT07270016
Exercise and Time of Day in Type 2 Diabetes
Rutgers, The State University of New Jersey
NCT05108987
Improvement of Hyperglycemia/Diabetes in Patients to Improve Safety
Northwestern University
NCT06096311
OASIS: Peer Support for T2DM in Appalachia (Peer Coaches)
Brittany L Smalls
NCT06003634
Reversibility of Brain Glucose Transport in Type 2 Diabetes Mellitus (T2DM)
Yale University
NCT05776563
The Acute T-Rex (Timing of Resistance Exercise) Study
University of Utah
NCT06366399
SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease
University of Nebraska
NCT06480786
Comparative Effectiveness of Empagliflozin in the US
Boehringer Ingelheim
NCT03363464
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
Signos
NCT05874635
Weight Loss Clinical Decision Support
HealthPartners Institute
NCT05198765
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
Novo Nordisk A/S
NCT03811561
Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
Eli Lilly and Company
NCT06260722
Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans
Massachusetts General Hospital
NCT01762046
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both
Novo Nordisk A/S
NCT06534411
Kaiser Permanente Evaluating Nutritional Interventions in Food-Insecure High-Risk Adults Study
Kaiser Permanente
NCT06061861
A Study to Test Whether Survodutide (BI 456906) Helps People Living With Overweight or Obesity Who Also Have Diabetes to Lose Weight
Boehringer Ingelheim
NCT06066528
Integrating Abbott Point-of-Care Technologies and the Community Scientist Model to Support HbA1c Testing Per ADA
Sansum Diabetes Research Institute
NCT05000840
Biological Sample Repository for Gastrointestinal Disorders
Pichamol Jirapinyo, MD, MPH
NCT05874726
Addressing Basic Needs to Improve Diabetes Outcomes in Medicaid Beneficiaries
Washington University School of Medicine
NCT03940209
Decreasing Cardiovascular Risk for Patients With Diabetes
Michigan State University
NCT04874116
Glucose Monitoring Comparison in Primary Care
HealthPartners Institute
NCT05222815
Promoting Successful Weight Loss in Primary Care in Louisiana Using Information Technology
Pennington Biomedical Research Center
NCT05523375
Using Early Time Restricted Feeding and Timed Light Therapy to Improve Glycemic Control in Adults With Type 2 Diabetes
University of Alabama at Birmingham
NCT04155619
Evaluating Telementoring for CHW-centered Diabetes Initiatives
The University of Texas Medical Branch, Galveston
NCT04835493
A Shared Decision Making Intervention for Diabetes Prevention in Women With a History of Gestational Diabetes Mellitus
University of California, Los Angeles
NCT04897945
Food Delivery, Remote Monitoring, and Coaching-Enhanced Education for Optimized Diabetes Management (FREEDOM)
University of Alabama at Birmingham
NCT05288452
Continuous Glucose Monitoring Devices in Hospitalized Veterans With Diabetes
VA Office of Research and Development
NCT03508934
A Family Dyad-focused Diabetes Self-Management Intervention for African American Adults
Ohio State University
NCT05905575
Food As MedicinE for Diabetes
University of North Carolina, Chapel Hill
NCT04828785
The Dietary Guidelines 3 Diet Patterns Study (DG3D): Phase 2
University of South Carolina
NCT05254496
The HIV, Adipose Tissue Immunology, and Metabolism Study
Vanderbilt University Medical Center
NCT04451980
Lowering Food Insecurity and Improving Diabetes With Financial Incentives
State University of New York at Buffalo
NCT05352022
A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy
Novo Nordisk A/S
NCT06797869
Diabetes Discharge Transitional CGM Study (DDT-CGM)
Intermountain Health Care
NCT04729985
Glycemic Control After Antenatal Corticosteroids in Women With Pregestational and Gestational Diabetes
University of Alabama at Birmingham
NCT04542148
Precision Diets for Diabetes Prevention
Stanford University
NCT03919877
Mastering Diabetes Study
Ohio University
NCT04454957
Surgical or Medical Treatment
Children's Hospital Medical Center, Cincinnati
NCT04128995
Electronic Diabetes Tune-Up Group (eDTU) for African Americans
Indiana University
NCT06321029
Study of Subcutaneously Administered ENT-03 for the Treatment of Obesity and Diabetes
Metabolics Pharma
NCT05925920
Michigan Men's Diabetes Project 2
University of Michigan
NCT05370781
Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans
University of Pittsburgh
NCT02710370
Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics
Washington University School of Medicine
NCT03348280
Self-Management and Glycemic Control in Adult Haitian Immigrants With Type 2 Diabetes
New York University
NCT04949568
MN-001 in Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus, and Hypertriglyceridemia
MediciNova
NCT05464784
Short Interval Resveratrol Trial in Cardiovascular Surgery
MaineHealth
NCT03762096
ADAM17 and Vascular Function in Diabetes
University of Missouri-Columbia
NCT04557228
CGM Monitoring in T2DM Patients Undergoing Orthopaedic Replacement Surgery
Stony Brook University
NCT05666479
A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease
Janssen Research & Development
NCT03492580
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 36 |
| Phase 2 | 35 |
| Phase 3 | 70 |
| Phase 4 | 26 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Diabetes Mellitus, Type 2 Trial Landscape
ClinicalTrials.gov lists 328 US studies indexed under Diabetes Mellitus, Type 2, and 58 of those are currently open to recruitment — roughly 18% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Diabetes Mellitus, Type 2 shows 96 late-stage studies (Phase 3 and Phase 4 combined) alongside 71 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Diabetes Mellitus, Type 2 is led by Novo Nordisk A/S with 48 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Diabetes Mellitus, Type 2?
PlainTrial tracks 328 US clinical trials for Diabetes Mellitus, Type 2, of which 58 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Diabetes Mellitus, Type 2?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.