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NCT04354246 · ClinicalTrials.gov registry record · Phase 1
COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies
A Phase 1 study of Multiple Myeloma and Lung Cancer, sponsored by Compugen.
- Active
- Registry status
- Phase 1
- Development phase
- 110
- Enrollment target
- 9
- Study locations
NCT04354246: Active Phase 1 study of Multiple Myeloma and Lung Cancer, sponsored by Compugen.
NCT04354246 is a Phase 1 study of Multiple Myeloma and Lung Cancer that is active but no longer recruiting, run by Compugen. The registered enrollment target is 110 participants, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (80% lower). The trial reports 9 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04354246, a Phase 1 study of Multiple Myeloma and Lung Cancer, is active but no longer recruiting, sponsored by Compugen.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 110 participants
- Enrollment target
- 9
- Study locations
Study Summary
Phase 1 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary antitumor activity of COM902 as monotherapy and in combination with COM701 in subjects with advanced malignancies.
Primary Outcome
Incidence of subjects with Adverse Events (AEs) as per CTCAE v5.0 and Dose-Limiting Toxicities (DLTs).
Conditions Studied
Interventions
- DRUG Dose escalation: COM902 monotherapy.
- COMBINATION_PRODUCT Evaluation of safety/tolerability: COM902 in combination with COM701 (both at the RDFE)
- DRUG Cohort expansion: COM902 (RDFE) monotherapy.
- DRUG Cohort expansion: COM902 in combination with COM701 (both at the RDFE).
- COMBINATION_PRODUCT Cohort expansion: Triplet combination of COM902 + COM701 + Pembrolizumab.
Study Locations (9)
Texas
- Mary Crowley Cancer Research - Dallas
- MD Anderson Cancer Center. - Houston
- The START Center for Cancer Care. - San Antonio
Florida
- Florida Cancer Specialists - Sarasota
Massachusetts
- Massachusetts General Hospital. - Boston
Michigan
- START Midwest. - Grand Rapids
Ohio
- The Ohio State University Comprehensive Cancer Center. - Columbus
Tennessee
- The University of Tennessee WEST Cancer Center. - Memphis
Wisconsin
- Froedtert & Medical College of Wisconsin - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 110 participants |
| Start Date | 2020-03-31 |
| Est. Completion | 2025-12-30 |
| Phase | Phase 1 |
What the registry record for NCT04354246 still lists
NCT04354246 is an interventional study that assigns participants to a tested intervention. The registered 110 participants enrollment target is mid-sized for trials with a published cap, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (80% lower).
The record links to 9 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 5 interventions - of which Dose escalation: COM902 monotherapy. is the first listed.
NCT04354246 lists 9 locations in 7 states (Texas, Florida, Massachusetts).
Frequently Asked Questions
What is clinical trial NCT04354246 about?
NCT04354246 is a clinical study titled "COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies". Phase 1 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary antitumor activity of COM902 as monotherapy and in combination with COM701 in subjects with advanced malignancies.
What is the current status of trial NCT04354246?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 110 participants. The study started on 2020-03-31. Estimated completion is 2025-12-30.
What conditions does trial NCT04354246 study?
This clinical trial studies the following conditions: Multiple Myeloma, Lung Cancer, Ovarian Cancer, Advanced Cancer, Colon Cancer.
What interventions are being tested in trial NCT04354246?
The interventions under investigation include: Dose escalation: COM902 monotherapy. (DRUG), Evaluation of safety/tolerability: COM902 in combination with COM701 (both at the RDFE) (COMBINATION_PRODUCT), Cohort expansion: COM902 (RDFE) monotherapy. (DRUG), Cohort expansion: COM902 in combination with COM701 (both at the RDFE). (DRUG), Cohort expansion: Triplet combination of COM902 + COM701 + Pembrolizumab. (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT04354246?
This trial is sponsored by Compugen, which has 5 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04354246 being conducted?
This trial has 9 study locations across Florida, Massachusetts, Michigan, Ohio, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04354246's enrollment target sits among peer trials
110 158th of 438 higher than 280 of 438 other Multiple Myeloma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple Myeloma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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