Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 1

A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors

NCT03872947 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of this study is to establish the safety and the recommended dose of TRK-950 in combination with FOLFIRI, Gemcitabine / Cisplatin, Gemcitabine / Carboplatin, Ramucirumab / Paclitaxel, PD1 inhibitors (Nivolumab or Pembrolizumab), and Imiquimod Cream, Bevacizumab, Gemcitabine / Carboplatin / Bevacizumab, Pegylated liposomal doxorubicin (PLD), Carboplatin / PLD / Bevacizumab and Paclitaxel for selected advanced solid tumors.

Interventions

  • DRUG Leucovorin
  • DRUG Irinotecan
  • BIOLOGICAL TRK-950

Study Locations (14)

Arizona

  • HonorHealth Research Institute — Scottsdale
  • AOA-HOPE — Tucson

California

  • USC Norris Comprehensive Cancer Center — Los Angeles
  • HOAG Memorial Hospital Presbyterian — Newport

Oregon

  • Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute and Research Center) — Eugene
  • Northwest Cancer Specialists — Portland

Texas

  • Texas Oncology, P.A. Baylor Charles A. Sammons Cancer Center — Dallas
  • Texas Oncology - Downtown Fort Worth Cancer Center — Fort Worth

Louisiana

  • Ochsner Clinic Foundation — New Orleans

New Jersey

  • Atlantic Health System — Morristown

New York

  • Perlmutter Cancer Center at NYU Langone — New York

Virginia

  • Virginia Cancer Specialists, PC — Leesburg

Trial Details

FieldValue
Enrollment Target 138 participants
Start Date 2019-04-26
Est. Completion 2026-06
Phase Phase 1

Sponsor

Toray Industries

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03872947

The ClinicalTrials.gov registry entry for NCT03872947 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 138 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Toray Industries, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Colorectal Cancer appearing as the primary indexed condition, and to 3 interventions — of which Leucovorin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03872947 reports 14 study locations spanning 10 distinct geographic areas — top geographies include Arizona, California, Oregon. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03872947 about?

NCT03872947 is a clinical study titled "A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors". The main purpose of this study is to establish the safety and the recommended dose of TRK-950 in combination with FOLFIRI, Gemcitabine / Cisplatin, Gemcitabine / Carboplatin, Ramucirumab / Paclitaxel, PD1 inhibitors (Nivolumab or Pembrolizumab), and Imiquimod Cream, Bevacizumab, Gemcitabine / Carbop...

What is the current status of trial NCT03872947?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 138 participants. The study started on 2019-04-26. Estimated completion is 2026-06.

What conditions does trial NCT03872947 study?

This clinical trial studies the following conditions: Colorectal Cancer, Ovarian Cancer, Melanoma, Solid Tumor, Bladder Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03872947?

The interventions under investigation include: Leucovorin (DRUG), Irinotecan (DRUG), TRK-950 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03872947?

This trial is sponsored by Toray Industries, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03872947 being conducted?

This trial has 14 study locations across Arizona, California, Louisiana, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial