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ACTIVE NOT RECRUITING Phase 2

ADP-A2M4CD8 Monotherapy and in Combination With Nivolumab in HLA-A2+ Subjects With MAGE-A4 Positive Ovarian Cancer (SURPASS-3)

NCT05601752 · View on ClinicalTrials.gov ↗

Study Summary

This is a phase 2, open-label, randomized, non-comparative clinical trial to evaluate the clinical outcome of ADP A2M4CD8 as monotherapy and in combination treatment with nivolumab in human leukocyte antigen (HLA) A2+ subjects with recurrent ovarian cancer positive for MAGE-A4.

Conditions Studied

Interventions

  • GENETIC Autologous genetically modified ADP-A2M4CD8 cells
  • COMBINATION_PRODUCT Autologous genetically modified ADP-A2M4CD8 cells in combination with Nivolumab

Study Locations (20)

Other

  • Centre Leon-Berard — Lyon
  • Institut de Cancerologie de Strasbourg — Strasbourg
  • Institut Gustave Roussy — Villejuif
  • Vall d'Hebron Unversity Hospital — Barcelona
  • Clinica Universidad de Navarra — Madrid
  • Hospital Universitario Ramón y Cajal — Madrid
  • Hospital Universitario Fundación Jiménez Díaz — Madrid
  • Hospital Universitario 12 de Octubre — Madrid
  • Centro Oncologico Clara Campal — Madrid

Arizona

  • Honor Health — Scottsdale

California

  • City of Hope — Duarte

Georgia

  • Augusta University — Augusta

Michigan

  • Karmanos Cancer Institute — Detroit

New Jersey

  • Rutgers Cancer Institute of NJ — New Brunswick

Ohio

  • Cleveland Clinic Foundation — Cleveland

Oklahoma

  • University of Oklahoma Health Sciences Center — Oklahoma City

Trial Details

FieldValue
Enrollment Target 66 participants
Start Date 2023-06-26
Est. Completion 2026-08-12
Phase Phase 2

Sponsor

USWM CT

7 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05601752

The ClinicalTrials.gov registry entry for NCT05601752 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 66 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is USWM CT, which has 7 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Ovarian Cancer appearing as the primary indexed condition, and to 2 interventions — of which Autologous genetically modified ADP-A2M4CD8 cells is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05601752 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Other, Arizona, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05601752 about?

NCT05601752 is a clinical study titled "ADP-A2M4CD8 Monotherapy and in Combination With Nivolumab in HLA-A2+ Subjects With MAGE-A4 Positive Ovarian Cancer (SURPASS-3)". This is a phase 2, open-label, randomized, non-comparative clinical trial to evaluate the clinical outcome of ADP A2M4CD8 as monotherapy and in combination treatment with nivolumab in human leukocyte antigen (HLA) A2+ subjects with recurrent ovarian cancer positive for MAGE-A4.

What is the current status of trial NCT05601752?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 66 participants. The study started on 2023-06-26. Estimated completion is 2026-08-12.

What conditions does trial NCT05601752 study?

This clinical trial studies the following conditions: Ovarian Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05601752?

The interventions under investigation include: Autologous genetically modified ADP-A2M4CD8 cells (GENETIC), Autologous genetically modified ADP-A2M4CD8 cells in combination with Nivolumab (COMBINATION_PRODUCT). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05601752?

This trial is sponsored by USWM CT, which has 7 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05601752 being conducted?

This trial has 20 study locations across Arizona, California, Georgia, Michigan, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial