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ACTIVE NOT RECRUITING Phase 1

Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer

NCT03907852 · View on ClinicalTrials.gov ↗

Study Summary

Gavocabtagene autoleucel (gavo-cel; TC-210) is a novel cell therapy that consists of autologous genetically engineered T cells expressing a single-domain antibody that recognizes human Mesothelin, fused to the CD3-epsilon subunit which, upon expression, is incorporated into the endogenous T cell receptor (TCR) complex. This Phase 1/2 study aims to establish the recommended Phase 2 dose (RP2D) and subsequently evaluate the efficacy of gavo-cel, with and without immuno-oncology agents, in patients with advanced mesothelin-expressing cancers, with overall response rate and disease control rate as the primary Phase 2 endpoints.

Interventions

  • DRUG Nivolumab
  • DRUG Ipilimumab
  • DRUG fludarabine
  • DRUG cyclophosphamide
  • BIOLOGICAL gavo-cel

Study Locations (11)

New York

  • Columbia University Medical Center — New York
  • Memorial Sloan Kettering Cancer Center — New York

California

  • University of California, San Francisco — San Francisco

Florida

  • University of Miami Sylvester Cancer Center — Miami

Illinois

  • University of Chicago Medical Center — Chicago

Maryland

  • National Cancer Institute — Bethesda

North Carolina

  • Duke University — Durham

Pennsylvania

  • University of Pennsylvania — Philadelphia

Tennessee

  • SCRI Oncology Partners — Nashville

Trial Details

FieldValue
Enrollment Target 57 participants
Start Date 2019-04-15
Est. Completion 2028-11-02
Phase Phase 1

Sponsor

TCR2 Therapeutics

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03907852

The ClinicalTrials.gov registry entry for NCT03907852 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 57 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is TCR2 Therapeutics, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Ovarian Cancer appearing as the primary indexed condition, and to 5 interventions — of which Nivolumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03907852 reports 11 study locations spanning 10 distinct geographic areas — top geographies include New York, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03907852 about?

NCT03907852 is a clinical study titled "Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer". Gavocabtagene autoleucel (gavo-cel; TC-210) is a novel cell therapy that consists of autologous genetically engineered T cells expressing a single-domain antibody that recognizes human Mesothelin, fused to the CD3-epsilon subunit which, upon expression, is incorporated into the endogenous T cell rec...

What is the current status of trial NCT03907852?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 57 participants. The study started on 2019-04-15. Estimated completion is 2028-11-02.

What conditions does trial NCT03907852 study?

This clinical trial studies the following conditions: Ovarian Cancer, Non Small Cell Lung Cancer, Cholangiocarcinoma, Mesothelioma, Non Small Cell Lung Cancer Metastatic. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03907852?

The interventions under investigation include: Nivolumab (DRUG), Ipilimumab (DRUG), fludarabine (DRUG), cyclophosphamide (DRUG), gavo-cel (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03907852?

This trial is sponsored by TCR2 Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03907852 being conducted?

This trial has 11 study locations across California, Florida, Illinois, Maryland, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial