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Cigarette Smoking: early-phase trial registry
20 of 46 indexed Cigarette Smoking trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #312 of 28,707 conditions by registered trial count.
46 US clinical trials · 20 currently recruiting · #312 of 28,707 conditions by registered trial count
Cigarette Smoking: 46 US clinical trials tracked, 20 recruiting.
Cigarette Smoking is the subject of 46 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Medical University of South Carolina, running 4 of these trials.
Enrollment posture brief
Registry condition cigarette-smoking
OPEN 20 | RECR 43% | LATE 2 | EARLY 15 | RANK #312 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Diet Habit (43% recruiting · 23 trials)
Cigarette Smoking lists 20 open slots (43% of 46 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Cigarette Smoking on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Cigarette Smoking is recruiting above its size-band peers.
20 of 46 indexed trials (43.5%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Cigarette Smoking trials is spread across many organizations.
Medical University of South Carolina accounts for 4 of 46 trials (8.7%). 30 distinct sponsors appear on at least one study for this condition label.
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Typical Cigarette Smoking enrolment sits around 87 participants.
Median target enrolment is 87 among the 46 trials that report a genuine target (sentinel values excluded). 24 of those (52.2%) plan for fewer than 100 participants.
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Cigarette Smoking research is mostly interventional.
45 interventional and 1 observational studies make up this index (97.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
46 total, page 1 of 1
A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse
Medical University of South Carolina
NCT06118502
The Positively Quit Trial for Smoking Cessation
University of South Florida
NCT04449458
Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit
Abramson Cancer Center at Penn Medicine
NCT07199517
Effects of Tax Proposals and Cigarette Availability on Tobacco Purchasing
Virginia Polytechnic Institute and State University
NCT07142668
E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder
NYU Langone Health
NCT05722561
Switch or Quit R01
Medical University of South Carolina
NCT06373679
The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers
Abramson Cancer Center at Penn Medicine
NCT06264154
Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers
Abramson Cancer Center at Penn Medicine
NCT06372899
Semaglutide for Post-Smoking Cessation Weight Management
The University of Texas Health Science Center, Houston
NCT06173778
Effect of Cannabis on Cigarette Use Behavior
Johns Hopkins University
NCT06609083
Beta-Adrenergic Modulation of Drug Cue Reactivity
University of Oklahoma
NCT05587361
Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing
Virginia Polytechnic Institute and State University
NCT07161050
Menthol, Inflammation, and Nicotine Transition Study
Rosalind Franklin University of Medicine and Science
NCT06232447
RTMS Targets Neural Circuits for Smoking Cessation
Medical University of South Carolina
NCT04903028
E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness
NYU Langone Health
NCT05815199
Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches
Medical University of South Carolina
NCT06678789
Smoking Cessation Intervention for American Indian Women Experiencing Intimate Partner Violence
Black Hills Center for American Indian Health
NCT06357767
Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults
University of Chicago
NCT06395415
Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use
Yale University
NCT06027840
Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures
Masonic Cancer Center, University of Minnesota
NCT06295757
Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks
University of Colorado, Denver
NCT05641974
Are Smokers Switching to Vaping at Lower Risk for Cancer? (Electronic Cigarettes and Cancer Risk)
University of Southern California
NCT03750825
The Effectiveness of Smoking Cessation Guidelines in the Emergency Department
University of Iowa
NCT00756704
Smoking Interventions for Hospital Patients
Massachusetts General Hospital
NCT01177176
Use and Harm Exposure in New Low Nicotine Cigarettes
University of Pennsylvania
NCT01202942
Smoking Study With Behavioral Therapy for Hypertensive Patients
UConn Health
NCT00879177
Reducing Tobacco Use Disparities Among Low-Income Adults
Northwestern University
NCT03077737
Resistance Training as an Aid to Smoking Cessation Treatment
Teachers College, Columbia University
NCT01951456
Cigarette Smoking Among Young Adults
University of Oklahoma
NCT04340947
Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties
University of Oklahoma
NCT05095779
Naltrexone for At-Risk and Problem Drinking in Smoking Cessation Treatment
Brown University
NCT00938886
Treatment of Smoking Among Individuals With PTSD
University of Pennsylvania
NCT00937235
Testing the ETM: Examination and Comparison of Different Methods
Virginia Polytechnic Institute and State University
NCT05946031
Text Messaging-Based Smoking Cessation Program for Homeless Youth
RAND
NCT03874585
E-cigarette Nicotine Study
University of Vermont
NCT04709471
Contingency Management and Pharmacotherapy for Smoking Cessation
UConn Health
NCT00683280
Brain Nicotine Receptor Density & Response to Nicotine Patch
Brentwood Biomedical Research Institute
NCT01526005
Semaglutide for Alcohol Use Disorder
University of North Carolina, Chapel Hill
NCT05520775
Treating Smokers With Mental Illness
University of Minnesota
NCT03822416
A Study to Assess the Pharmacokinetics of Oral Nicotine Pouches and Lozenges in Healthy Adults
British American Tobacco (Investments) Limited
NCT04755348
Contingency Management, Quitting Smoking, and ADHD
Duke University
NCT02266784
Families With Substance Use and Psychosis: A Pilot Study
Mclean Hospital
NCT04284813
New Approaches to Smoking Cessation in Heavy Drinkers
Yale University
NCT02151591
E-cigarettes for Harm Reduction in Adults With Asthma
Brown University
NCT05278065
A Study of Inhalation of 20,000 EU CCRE and Mucociliary Clearance (MCC) in Otherwise Healthy Individuals Who Are Current Cigarette Smokers
University of North Carolina, Chapel Hill
NCT00924768
Behavioral Economic Methods for Assessing Tobacco Product Abuse Liability: Study 7
Virginia Polytechnic Institute and State University
NCT03496922
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 8 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Cigarette Smoking records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Cigarette Smoking trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Cigarette Smoking page
46 registered trials, 20 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 20 Cigarette Smoking trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Medical University of South Carolina sponsors the most Cigarette Smoking trials on record, review their full trial history before evaluating a specific study. See Medical University of South Carolina's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Cigarette Smoking condition card totals 46 registered trials; most-linked intervention Varenicline; top US site state Pennsylvania. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.