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Cigarette Smoking
Open-data reference.
46 US clinical trials · 20 currently recruiting
Active & Recent Trials
A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse
Medical University of South Carolina
NCT06118502
The Positively Quit Trial for Smoking Cessation
University of South Florida
NCT04449458
Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit
Abramson Cancer Center at Penn Medicine
NCT07199517
Effects of Tax Proposals and Cigarette Availability on Tobacco Purchasing
Virginia Polytechnic Institute and State University
NCT07142668
E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder
NYU Langone Health
NCT05722561
Switch or Quit R01
Medical University of South Carolina
NCT06373679
The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers
Abramson Cancer Center at Penn Medicine
NCT06264154
Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers
Abramson Cancer Center at Penn Medicine
NCT06372899
Semaglutide for Post-Smoking Cessation Weight Management
The University of Texas Health Science Center, Houston
NCT06173778
Effect of Cannabis on Cigarette Use Behavior
Johns Hopkins University
NCT06609083
Beta-Adrenergic Modulation of Drug Cue Reactivity
University of Oklahoma
NCT05587361
Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing
Virginia Polytechnic Institute and State University
NCT07161050
Menthol, Inflammation, and Nicotine Transition Study
Rosalind Franklin University of Medicine and Science
NCT06232447
RTMS Targets Neural Circuits for Smoking Cessation
Medical University of South Carolina
NCT04903028
E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness
NYU Langone Health
NCT05815199
Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches
Medical University of South Carolina
NCT06678789
Smoking Cessation Intervention for American Indian Women Experiencing Intimate Partner Violence
Black Hills Center for American Indian Health
NCT06357767
Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults
University of Chicago
NCT06395415
Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use
Yale University
NCT06027840
Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures
Masonic Cancer Center, University of Minnesota
NCT06295757
Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks
University of Colorado, Denver
NCT05641974
Are Smokers Switching to Vaping at Lower Risk for Cancer? (Electronic Cigarettes and Cancer Risk)
University of Southern California
NCT03750825
The Effectiveness of Smoking Cessation Guidelines in the Emergency Department
University of Iowa
NCT00756704
Smoking Interventions for Hospital Patients
Massachusetts General Hospital
NCT01177176
Use and Harm Exposure in New Low Nicotine Cigarettes
University of Pennsylvania
NCT01202942
Smoking Study With Behavioral Therapy for Hypertensive Patients
UConn Health
NCT00879177
Reducing Tobacco Use Disparities Among Low-Income Adults
Northwestern University
NCT03077737
Resistance Training as an Aid to Smoking Cessation Treatment
Teachers College, Columbia University
NCT01951456
Cigarette Smoking Among Young Adults
University of Oklahoma
NCT04340947
Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties
University of Oklahoma
NCT05095779
Naltrexone for At-Risk and Problem Drinking in Smoking Cessation Treatment
Brown University
NCT00938886
Treatment of Smoking Among Individuals With PTSD
University of Pennsylvania
NCT00937235
Testing the ETM: Examination and Comparison of Different Methods
Virginia Polytechnic Institute and State University
NCT05946031
Text Messaging-Based Smoking Cessation Program for Homeless Youth
RAND
NCT03874585
E-cigarette Nicotine Study
University of Vermont
NCT04709471
Contingency Management and Pharmacotherapy for Smoking Cessation
UConn Health
NCT00683280
Brain Nicotine Receptor Density & Response to Nicotine Patch
Brentwood Biomedical Research Institute
NCT01526005
Semaglutide for Alcohol Use Disorder
University of North Carolina, Chapel Hill
NCT05520775
Treating Smokers With Mental Illness
University of Minnesota
NCT03822416
A Study to Assess the Pharmacokinetics of Oral Nicotine Pouches and Lozenges in Healthy Adults
British American Tobacco (Investments) Limited
NCT04755348
Contingency Management, Quitting Smoking, and ADHD
Duke University
NCT02266784
Families With Substance Use and Psychosis: A Pilot Study
Mclean Hospital
NCT04284813
New Approaches to Smoking Cessation in Heavy Drinkers
Yale University
NCT02151591
E-cigarettes for Harm Reduction in Adults With Asthma
Brown University
NCT05278065
A Study of Inhalation of 20,000 EU CCRE and Mucociliary Clearance (MCC) in Otherwise Healthy Individuals Who Are Current Cigarette Smokers
University of North Carolina, Chapel Hill
NCT00924768
Behavioral Economic Methods for Assessing Tobacco Product Abuse Liability: Study 7
Virginia Polytechnic Institute and State University
NCT03496922
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 7 |
| Phase 2 | 8 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cigarette Smoking Trial Landscape
ClinicalTrials.gov lists 46 US studies indexed under Cigarette Smoking, and 20 of those are currently open to recruitment — roughly 43% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Cigarette Smoking shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 15 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Cigarette Smoking is led by Medical University of South Carolina with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 46 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cigarette Smoking?
PlainTrial tracks 46 US clinical trials for Cigarette Smoking, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cigarette Smoking?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.