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ClinicalTrials.gov 20 recruiting now early-phase tilt

Normal Physiology: early-phase trial registry

20 of 26 indexed Normal Physiology trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #627 of 28,707 conditions by registered trial count.

26 US clinical trials · 20 currently recruiting · #627 of 28,707 conditions by registered trial count

Normal Physiology: 26 US clinical trials tracked, 20 recruiting.

Normal Physiology is the subject of 26 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Neurological Disorders and Stroke (NINDS), running 7 of these trials.

Enrollment posture brief

Registry condition normal-physiology

OPEN 20 | RECR 77% | LATE 0 | EARLY 2 | RANK #627 | SPON 7

Nearest open-share peer: Firearm Injury (77% recruiting · 13 trials)

Normal Physiology (this)77%Autoimmune Diseases53.8%Cancer Survivor26.9%Anaplastic Large Cell Lympho19.2%Adult Acute Myeloid Leukemia0%
Open-enrollment share among volume-matched conditions near Normal Physiology

Normal Physiology lists 20 open slots (77% of 26 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Normal Physiology on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Normal Physiology is recruiting above its size-band peers.

    20 of 26 indexed trials (76.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Normal Physiology research.

    National Institute of Neurological Disorders and Stroke (NINDS) accounts for 7 of 26 trials (26.9%). 11 distinct sponsors appear on at least one study for this condition label.

  3. Typical Normal Physiology enrolment sits around 200 participants.

    Median target enrolment is 200 among the 26 trials that report a genuine target (sentinel values excluded). 7 of those (26.9%) plan for fewer than 100 participants.

  4. Normal Physiology splits between interventional and observational designs.

    12 interventional and 14 observational studies make up this index (46.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 12

Open and recent trials

26 total, page 1 of 1

RECRUITING 10,200 participants

Perception, Sensation, Cognition and Action in Humans

National Eye Institute (NEI)

NCT03407066

RECRUITING 10,000 participants

Clinical and Scientific Assessment of Pain and Painful Disorders

National Center for Complementary and Integrative Health (NCCIH)

NCT02707029

RECRUITING 2,378 participants

Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli

National Institute of Neurological Disorders and Stroke (NINDS)

NCT02629107

RECRUITING 2,000 participants

A Natural History Study of Metabolic Sizing in Health and Disease

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT05398783

RECRUITING 2,000 participants

NIEHS Repository of Stored Biological Samples for Future Use

National Institute of Environmental Health Sciences (NIEHS)

NCT05666739

RECRUITING 1,000 participants

Development of 3T Magnetic Resonance Research Methods for NIA Studies

National Institute on Aging (NIA)

NCT01324206

RECRUITING NA 700 participants

Sociocultural & Biobehavioral Influences on Pain Expression and Assessment

National Center for Complementary and Integrative Health (NCCIH)

NCT03258580

RECRUITING NA 620 participants

Defining Neurobiological Links Between Substance Use and Mental Illness

National Institute on Drug Abuse (NIDA)

NCT05538910

RECRUITING Early Phase 1 600 participants

Developing Transcranial Neuromodulation Protocols for Learning and Decision-Making

National Institute on Drug Abuse (NIDA)

NCT06561828

RECRUITING 550 participants

Development and Validation of Learning and Decision-Making Tasks

National Institute on Drug Abuse (NIDA)

NCT05707806

RECRUITING NA 500 participants

Neural and Psychological Mechanisms of Pain Perception

National Center for Complementary and Integrative Health (NCCIH)

NCT02446262

RECRUITING NA 200 participants

MRS Measurement of Glutamate and GABA Metabolism in Brain

National Institute of Mental Health (NIMH)

NCT00109174

RECRUITING 200 participants

Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects

National Institute of Neurological Disorders and Stroke (NINDS)

NCT05604534

RECRUITING NA 192 participants

Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT02535702

RECRUITING 150 participants

Investigating the Impact of Obesity on Pubertal Development in Girls

National Institute of Environmental Health Sciences (NIEHS)

NCT02583646

RECRUITING 150 participants

Investigational Use of Neuromuscular Ultrasound

National Institute of Neurological Disorders and Stroke (NINDS)

NCT05237973

RECRUITING NA 120 participants

The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT05545306

RECRUITING 114 participants

Influence of Brain Oscillation-Dependent TMS on Motor Function

National Institute of Neurological Disorders and Stroke (NINDS)

NCT03288220

RECRUITING NA 75 participants

Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array

National Institute of Mental Health (NIMH)

NCT04950309

RECRUITING NA 48 participants

Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms

Massachusetts General Hospital

NCT05829044

COMPLETED 359 participants

Volunteer Screening for Vaccine and Antivirals Clinical Trials

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01593709

COMPLETED NA 43 participants

Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory

National Institute of Neurological Disorders and Stroke (NINDS)

NCT04694131

COMPLETED 40 participants

Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex

National Institute of Neurological Disorders and Stroke (NINDS)

NCT04431011

COMPLETED NA 39 participants

Study of Volition: Behavioral Analysis and Clinical Neurophysiological Analysis

National Institute of Neurological Disorders and Stroke (NINDS)

NCT04344470

COMPLETED Phase 1 25 participants

Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT03326245

COMPLETED 10 participants

Studying Cell Immune Responses to a Live Flu Vaccine in Healthy Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01730144

Phase Distribution

PhaseTrial count
Phase 1 2

Named interventions

Most-linked intervention names on Normal Physiology records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

EMG Device
1 trials
Intravenous methylphenidate Drug
1 trials
Methylphenidate Pill Drug
1 trials
Placebo instructions Behavioral
1 trials
Thermal Pain Behavioral
1 trials
Instructions Behavioral
1 trials
+200% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein Dietary supplement
1 trials
+150% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat Dietary supplement
1 trials

US sites by state

Facility locations filed on Normal Physiology trials. A trial with sites in several states counts in each.

Maryland 22 trials
North Carolina 2 trials
Massachusetts 1 trials
Arizona 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Normal Physiology page

26 registered trials, 20 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Normal Physiology condition card totals 26 registered trials; most-linked intervention EMG; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.