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NCT02446262 · ClinicalTrials.gov registry record · NA
Neural and Psychological Mechanisms of Pain Perception
A NA study of Pain and Healthy Volunteers, sponsored by National Center for Complementary and Integrative Health (NCCIH).
- Recruiting
- Registry status
- NA
- Development phase
- 500
- Enrollment target
- 1
- Study location
NCT02446262: Recruiting NA study of Pain and Healthy Volunteers, sponsored by National Center for Complementary and Integrative Health (NCCIH).
NCT02446262 is a NA study of Pain and Healthy Volunteers that is actively recruiting participants, run by National Center for Complementary and Integrative Health (NCCIH). The registered enrollment target is 500 participants, above the 303-participant average among 374 other Pain trials with a reported enrollment target (65% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02446262, a NA study of Pain and Healthy Volunteers, is actively recruiting participants, sponsored by National Center for Complementary and Integrative Health (NCCIH).
- RECRUITING
- Registry status
- NA
- Development phase
- 500 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: \- Painful stimuli cause changes in a network of brain regions called the "Pain Matrix." But most of these regions respond to many other stimuli, not just pain. Researchers want to understand how different factors influence pain. They want to test what happens when people expect different levels of pain and receive treatments that can modify pain. They want to see if these factors influence decisions about pain and how the body responds to it. They also want to compare pain with responses like taste and vision. Objectives: \- To better understand how pain and emotions are processed and influenced by psychological factors. Eligibility: \- Healthy volunteers ages 18-50. Design: * This study requires 1 to 2 clinic visits that last 1 to 3 hours. * Participants will be screened with medical history and physical exam. * Some participants will have one or more magnetic resonance imaging (MRI) scans of their brain. For MRI, participants will lie on a table that slides in and out of a cylinder. The scanner makes loud knocking noises. They will get earplugs. * Participants heart activity will be recorded with electrocardiogram. Their pulse, sweating, and breathing will be monitored. * Some participants will take a taste test. Others may perform simple tasks. Others may receive pain in their arm, leg, or hand. The pain will come from heat or electric shocks. Others may judge pain using a topical pain-relieving cream. Some of these tests may be given during MRI. * Participants will fill out questionnaires. * The study will last 3 years.
Primary Outcome
In behavioral and fMRI experiments, we measure autonomic responses in anticipation and response to painful and non-painful stimuli using non-invasive measures.
Conditions Studied
Interventions
- BEHAVIORAL Attention
- BEHAVIORAL Instructions
- BEHAVIORAL Thermal Pain
- BEHAVIORAL Placebo instructions
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 500 participants |
| Start Date | 2015-06-11 |
| Est. Completion | 2027-02-20 |
| Phase | NA |
What NCT02446262 shows while recruiting
NCT02446262 is an interventional study that assigns participants to a tested intervention. The registered 500 participants enrollment target is mid-sized for trials with a published cap, above the 303-participant average among 374 other Pain trials with a reported enrollment target (65% higher).
The record links to 3 conditions, with Pain appearing as the primary indexed condition, and to 4 interventions - of which Attention is the first listed.
NCT02446262 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT02446262 about?
NCT02446262 is a clinical study titled "Neural and Psychological Mechanisms of Pain Perception". Background: \- Painful stimuli cause changes in a network of brain regions called the "Pain Matrix." But most of these regions respond to many other stimuli, not just pain. Researchers want to understand how different factors influence pain. They want to test what happens when people expect differe...
What is the current status of trial NCT02446262?
This trial is currently recruiting. It is a NA study. The enrollment target is 500 participants. The study started on 2015-06-11. Estimated completion is 2027-02-20.
What conditions does trial NCT02446262 study?
This clinical trial studies the following conditions: Pain, Healthy Volunteers, Normal Physiology.
What interventions are being tested in trial NCT02446262?
The interventions under investigation include: Attention (BEHAVIORAL), Instructions (BEHAVIORAL), Thermal Pain (BEHAVIORAL), Placebo instructions (BEHAVIORAL).
Who is sponsoring clinical trial NCT02446262?
This trial is sponsored by National Center for Complementary and Integrative Health (NCCIH), which has 203 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02446262 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02446262's enrollment target sits among peer trials
500 30th of 374 higher than 342 of 374 other Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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