Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05604534 · ClinicalTrials.gov registry record
Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects
A clinical trial of Normal Physiology, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Recruiting
- Registry status
- 200
- Enrollment target
- 1
- Study location
NCT05604534: Recruiting study of Normal Physiology, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT05604534 is a study of Normal Physiology that is actively recruiting participants, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 200 participants, below the 1,285-participant average among 25 other Normal Physiology trials with a reported enrollment target (84% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05604534, a study of Normal Physiology, is actively recruiting participants, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- RECRUITING
- Registry status
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: Magnetic resonance imaging (MRI), which uses strong magnets to get images of structures inside the body, is a valuable tool in modern medicine. But researchers are always looking for ways to improve this technology. To better understand how to use MRI to diagnose problems, researchers need to collect more data from scans of healthy people. Objective: To get MRI scans of healthy people to improve the measurements doctors can make from the images. Eligibility: People aged 18 years or older in good general health. Design: Participants will be screened. They will have a physical exam focused on their nervous system. They will complete questionnaires. Participants will have at least 1 MRI scan. The target of the scan may be the brain, liver, prostate, breast, or other body part. Before the scan, participants will remove any metallic objects. They will lie on a narrow table that moves into a long, narrow tube. They may have special pads placed around them to help them remain still. Participants will hear loud noises during the scan. They will get earplugs or earmuffs to wear to muffle the sound. They can communicate with the MRI technician and will have an emergency button to squeeze at any time if they want the scan to stop. The scan will take up to 2 hours. Some participants may be asked to perform tasks on a computer screen during the scan. Participants may return for up to 5 scans in 3 months. Some may have as many as 30 MRI visits per year. They may remain in the study for up to 2 years.
Primary Outcome
For a given qMRI metric (e.g. mean diffusivity, T1, T2) under investigation and a given organ (e.g. brain, peripheral nerve, prostate) under investigation: 1) Map values of the metric under investigation throughout the organ 2) Measure the variability of the measured values in repeated scans on one MRI scanner 3) Measure the variability of the measured values acquired using proposed improvements in experimental design and document that a proposed improvement (e.g., improved pulse sequence acquis
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2023-02-02 |
| Est. Completion | 2041-03-31 |
What NCT05604534 shows while recruiting
NCT05604534 is an observational study that tracks outcomes without assigning an intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, below the 1,285-participant average among 25 other Normal Physiology trials with a reported enrollment target (84% lower).
The record links to 1 condition, with Normal Physiology appearing as the primary indexed condition, and to 0 interventions.
NCT05604534 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT05604534 about?
NCT05604534 is a clinical study titled "Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects". Background: Magnetic resonance imaging (MRI), which uses strong magnets to get images of structures inside the body, is a valuable tool in modern medicine. But researchers are always looking for ways to improve this technology. To better understand how to use MRI to diagnose problems, researchers n...
What is the current status of trial NCT05604534?
This trial is currently recruiting. The enrollment target is 200 participants. The study started on 2023-02-02. Estimated completion is 2041-03-31.
What conditions does trial NCT05604534 study?
This clinical trial studies the following conditions: Normal Physiology.
Who is sponsoring clinical trial NCT05604534?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05604534 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Normal Physiology
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05604534's enrollment target sits among peer trials
200 13th of 25 higher than 12 of 25 other Normal Physiology trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Normal Physiology trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
A Natural History Study of Metabolic Sizing in Health and Disease
RECRUITING
-
Investigating the Impact of Obesity on Pubertal Development in Girls
RECRUITING
-
Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction
RECRUITING · NA
-
Influence of Brain Oscillation-Dependent TMS on Motor Function
RECRUITING
-
Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
RECRUITING · NA
-
Clinical and Scientific Assessment of Pain and Painful Disorders
RECRUITING
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00107289 · 200 participants · Phase 2
Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma
- NCT00177268 · 200 participants
Blood, Urine, and Tissue Collection for Cutaneous Lymphoma, Eczema, and Atopic Dermatitis Research
- NCT00493688 · 200 participants
A Study to Determine Whether Perioperative Energy Dynamics Correlates With Postoperative Outcomes
- NCT00568490 · 200 participants
Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI