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NCT03258580 · ClinicalTrials.gov registry record · NA

Sociocultural & Biobehavioral Influences on Pain Expression and Assessment

A NA study of Pain and Healthy Volunteers, sponsored by National Center for Complementary and Integrative Health (NCCIH).

Recruiting
Registry status
NA
Development phase
700
Enrollment target
1
Study location

NCT03258580: Recruiting NA study of Pain and Healthy Volunteers, sponsored by National Center for Complementary and Integrative Health (NCCIH).

NCT03258580 is a NA study of Pain and Healthy Volunteers that is actively recruiting participants, run by National Center for Complementary and Integrative Health (NCCIH). The registered enrollment target is 700 participants, above the 302-participant average among 374 other Pain trials with a reported enrollment target (132% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT03258580, a NA study of Pain and Healthy Volunteers, is actively recruiting participants, sponsored by National Center for Complementary and Integrative Health (NCCIH).

RECRUITING
Registry status
NA
Development phase
700 participants
Enrollment target
1
Study location

Study Summary

Objective The current proposal investigates behavioral, psychophysiological, and social processes that may help explain biases and disparate outcomes in pain. Health disparities, or health outcomes that adversely affect disadvantaged populations, are pervasive and apparent in many diseases and symptoms, including pain. Pain is the number one reason individuals seek medical treatment. Health disparities in pain encompass both differences in pain experience and treatment for pain. For instance, research indicates that Black individuals report increased pain and have reduced pain tolerance relative to White individuals, yet doctors are less likely to treat minority patients pain and underestimate their pain experience. This project aims to address this systemic discrepancy by focusing on interpersonal processes that may contribute to these disparities, including socially-relevant responses to pain (i.e. pain expression) and pain assessment (e.g. visual attention). The proposed research aims to determine whether the study of pain expressions and their assessment can yield insights on how social factors shape pain and its treatment. Further, we test the efficacy of potential interventions designed to improve accuracy and reduce biases in pain assessment. If successful, this work will form the foundation of a new research program that will link the field of pain research with the field of social neuroscience, and forge new insights on the critical problem of health disparities in pain. Study population We will accrue up to 700 total healthy volunteers to target 240 completers Design Our overall aim is to understand how social factors influence the assessment and management of pain, and to gain insight into psychosocial processes that may underlie health disparities in pain. We propose a series of studies designed to test these links. First, we will measure pain perception and physiological responses to painful stimuli in a diverse group of individuals to test for soc

Primary Outcome

We measure facial responses to painful stimuli in substudy 1 and eye position in substudy 2 and 3.

Interventions

  • DEVICE Medoc thermal stimulator
  • DEVICE Electric shock stimulator
  • DEVICE Cold water bath
  • BEHAVIORAL Pain assessment performance feedback

Study Locations (1)

Maryland

  • National Institutes of Health Clinical Center - Bethesda

Trial Details

FieldValue
Enrollment Target 700 participants
Start Date 2018-05-09
Est. Completion 2027-05-30
Phase NA

What NCT03258580 shows while recruiting

NCT03258580 is an interventional study that assigns participants to a tested intervention. The registered 700 participants enrollment target is mid-sized for trials with a published cap, above the 302-participant average among 374 other Pain trials with a reported enrollment target (132% higher).

The record links to 3 conditions, with Pain appearing as the primary indexed condition, and to 4 interventions - of which Medoc thermal stimulator is the first listed.

NCT03258580 reports a single indexed study location in Maryland.

Frequently Asked Questions

What is clinical trial NCT03258580 about?

NCT03258580 is a clinical study titled "Sociocultural & Biobehavioral Influences on Pain Expression and Assessment". Objective The current proposal investigates behavioral, psychophysiological, and social processes that may help explain biases and disparate outcomes in pain. Health disparities, or health outcomes that adversely affect disadvantaged populations, are pervasive and apparent in many diseases and symp...

What is the current status of trial NCT03258580?

This trial is currently recruiting. It is a NA study. The enrollment target is 700 participants. The study started on 2018-05-09. Estimated completion is 2027-05-30.

What conditions does trial NCT03258580 study?

This clinical trial studies the following conditions: Pain, Healthy Volunteers, Normal Physiology.

What interventions are being tested in trial NCT03258580?

The interventions under investigation include: Medoc thermal stimulator (DEVICE), Electric shock stimulator (DEVICE), Cold water bath (DEVICE), Pain assessment performance feedback (BEHAVIORAL).

Who is sponsoring clinical trial NCT03258580?

This trial is sponsored by National Center for Complementary and Integrative Health (NCCIH), which has 203 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT03258580 being conducted?

This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Similar trials for Pain

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT03258580's enrollment target sits among peer trials

700 20th of 374 higher than 355 of 374 other Pain trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Source: ClinicalTrials.gov NCT03258580, the US trial registry maintained by the National Library of Medicine. NCT03258580 (mid enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.