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NCT04694131 · ClinicalTrials.gov registry record · NA
Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory
A NA study of Normal Physiology, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Completed
- Registry status
- NA
- Development phase
- 43
- Enrollment target
- 1
- Study location
NCT04694131: Completed NA study of Normal Physiology, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT04694131 is a NA study of Normal Physiology that has completed, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 43 participants, below the 1,291-participant average among 25 other Normal Physiology trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04694131, a NA study of Normal Physiology, has completed, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- COMPLETED
- Registry status
- NA
- Development phase
- 43 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: Transcranial magnetic stimulation (TMS) of the brain has been used to change the activity and connections in the brain to improve memory. Researchers are interested in how these brain changes cause memory improvements and how activity at the time of stimulation may change the effects of TMS. Objective: To learn how brain stimulation can be used to improve memory. Eligibility: Healthy adults ages 18-40 Design: Participants will be screened with a medical record review. Participants will have 3 study visits. At visit 1, participants will have a physical exam and will talk about their health. They will have magnetic resonance imaging (MRI). The MRI scanner is a metal cylinder surrounded by a strong magnetic field. During the MRI, participants will lie on a table that can slide in and out of the scanner. A coil will be placed over the head. Participants will be asked to keep their eyes focused on a small cross on a computer screen inside the scanner. The scanner makes loud noises. Participants will get earplugs. At visits 2 and 3, participants will have TMS and perform tasks. For TMS, a wire coil encased in plastic is held on the scalp. When the coil is triggered, a brief electrical current passes through the coil and creates a magnetic pulse that stimulates the brain. During TMS, an electroencephalogram (EEG) will record brain activity. For the EEG, a cloth cap with electrodes is fitted on the participant s head. Participants will complete a memory task and a spatial processing task. They will also complete surveys about their mental state. Participation will last 2-3 weeks.
Primary Outcome
Participants completed a memory task with simultaneous EEG acquisition and transcranial magnetic stimulation (TMS) delivered to either a memory-relevant parietal lobe target or a vertex control site. Participants were shown a series of objects in one of four quadrants on the screen, with TMS delivered either prior to or concurrent with the trial onset. They were instructed to remember the object and the location. This outcome measure examines the accuracy of memory for the item and the location
Conditions Studied
Interventions
- DEVICE TMS
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 43 participants |
| Start Date | 2021-07-09 |
| Est. Completion | 2023-02-24 |
| Phase | NA |
What the finished NCT04694131 record still lists
NCT04694131 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 43 participants, a relatively small participant target, below the 1,291-participant average among 25 other Normal Physiology trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Normal Physiology appearing as the primary indexed condition, and to 1 intervention - of which TMS is the first listed.
NCT04694131 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT04694131 about?
NCT04694131 is a clinical study titled "Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory". Background: Transcranial magnetic stimulation (TMS) of the brain has been used to change the activity and connections in the brain to improve memory. Researchers are interested in how these brain changes cause memory improvements and how activity at the time of stimulation may change the effects of...
What is the current status of trial NCT04694131?
This trial is currently completed. It is a NA study. The enrollment target is 43 participants. The study started on 2021-07-09. Estimated completion is 2023-02-24.
What conditions does trial NCT04694131 study?
This clinical trial studies the following conditions: Normal Physiology.
What interventions are being tested in trial NCT04694131?
The interventions under investigation include: TMS (DEVICE).
Who is sponsoring clinical trial NCT04694131?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04694131 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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