National Eye Institute (NEI)
Trial Pipeline
National Ophthalmic Genotyping and Phenotyping Network (eyeGENE (Registered Trademark)), Stage 3 - Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases
NCT06491615
Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease
NCT04289571
Stargardt-like Macular Dystrophy (STDG3) Secondary to Mutations in ELOVL4
NCT04591483
Oral Metformin for Treatment of ABCA4 Retinopathy
NCT04545736
Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated With Age-Related Macular Degeneration
NCT04339764
Perception, Sensation, Cognition and Action in Humans
NCT03407066
Clinical and Molecular Studies in Families With Inherited Eye Disease
NCT02771236
Natural History, Pathogenesis, and Outcome of Ocular Disorders
NCT02821767
Natural History of Spinocerebellar Ataxia Type 7 (SCA7)
NCT02741440
Rod and Cone Mediated Function in Retinal Disease
NCT02617966
Genetics of Inherited Eye Disease
NCT02471287
Adaptive Optics Retinal Imaging
NCT02317328
Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye Conditions
NCT02077894
Pathogenesis and Genetics of Microphthalmia, Anophthalmia and Uveal Coloboma (MAC)
NCT01778543
National Eye Institute Biorepository for Retinal Diseases
NCT01496625
Cell Collection to Study Eye Diseases
NCT01432847
Genotype-Phenotype Study of Patients With Plaquenil -Induced Retinal Toxicity, With Evaluation of the ABCA4 Gene
NCT01145196
Screening for Research Participants
NCT00655096
Training to Modify Fixational Eye Movements for Optimizing Visual Performance in People With Central Vision Loss
NCT06670989
Retrospective Case Series of Trans-scleral Cryotherapy for Retinal Hemangioblastoma
NCT04458935
Dark Adaptation in Participants With Age-Related Macular Degeneration
NCT03225131
Natural History of Eye Diseases Related to ABCA4 Mutations
NCT01736293
Study of Dark Adaptation in Age-Related Macular Degeneration
NCT01352975
Age-Related Eye Disease Study (AREDS) Follow-Up
NCT00594672
Clinical and Genetic Studies of X-Linked Juvenile Retinoschisis
NCT00055029
Potential Environmental Causes of Uveal Coloboma
NCT04833361
Mothers Experiences With X-linked Retinoschisis Compared to Fathers Experiences
NCT03354403
Ustekinumab (STELARA) for the Treatment of Active Sight-Threatening Uveitis (STAR Study)
NCT02911116
The Focal Electro-Oculogram in Macular Disease
NCT02225119
Intestinal Bacteria and Ocular Inflammatory Disease
NCT01859299
Study of the Effects of Supplements on Eye Disease in Participants From the Age-Related Eye Disease Study
NCT01915238
Optiquel® as Corticosteroid-sparing Therapy for Chronic Noninfectious Uveitis
NCT01195948
Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti
NCT00876434
Pilot Study of the Evaluation of Subconjunctival Sirolimus in the Treatment of Bilateral GA Associated With AMD
NCT00766649
Validation of Computerized Vision-Targeted Quality-of-Life Questionnaires
NCT00678860
High Speed Indocyanine Green Angiography Findings in Ranibizumab Treatment for Wet Age-related Macular Degeneration
NCT00656903
Genetics and Markers of Degenerative and Inflammatory Eye Diseases
NCT00647439
Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure
NCT00471731
Injected Ranibizumab to Treat Macular Telangiectasia With New Blood Vessel Formation
NCT00457067
Clinical and Genetic Studies in Families With Myopia and Related Diseases
NCT00272376
Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia
NCT00265590
Molecular Genetics of Retinal Degenerations
NCT00231010
Triamcinolone Acetonide Injections to Treat Diabetic Macular Edema
NCT00231023
Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis
NCT00130637
Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study
NCT00116090
Steroid Injections vs. Standard Treatment for Macular Edema Due to Retinal Blood Vessel Blockage
NCT00106132
Intravitreal v. Sub-tenon Injections of Triamcinolone Acetonide for Macular Edema in Retinal Disorders
NCT00101764
Triamcinolone Acetonide Plus Laser Therapy to Treat Age-Related Macular Degeneration
NCT00100009
Immune Indicators of Uveitis
NCT00089739
Efficacy of Elevated CD4 Counts on CMV Retinitis
NCT00091884
Evaluation and Treatment of Eye Complications of Vaccinia Vaccination
NCT00081835
Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases
NCT00076271
Studies in Families With Corneal Dystrophy or Other Inherited Corneal Diseases
NCT00357435
Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa
NCT00065455
Immune Responses to Antigens in Non-infectious Eye Inflammatory Diseases
NCT00357071
Clinical and Genetic Studies of Families With Congenital or Hereditary Cataracts
NCT00056771
EYE001 to Treat Retinal Tumors in Patients With Von Hippel-Lindau Syndrome
NCT00056199
Biological Markers in Retinal Vasculitis
NCT00050492
Identification and Treatment of Feeder Vessels in Macular Degeneration
NCT00018070
Genetic Study of Age-Related Macular Degeneration
NCT00357578
Eye Muscle Surgery to Treat Congenital Nystagmus
NCT00001866
Amblyopia (Lazy Eye) Treatment Study
NCT00001864
Screening for Studies on Nystagmus and Strabismus
NCT00001861
Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops
NCT00001731
Test of QLS Device to Detect Early Cataracts
NCT00001617
Cataract Surgery to Obtain Human Lens Material for the Study of Nuclear Cataracts
NCT00001613
The Effects of Light Reduction on Retinopathy of Prematurity (Light-ROP)
NCT00000156
Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) - Outcome Study of Cryotherapy for Retinopathy of Prematurity
NCT00000133
Visual Stimulus and Eye Movement
NCT00001172
Pigment Dispersion Syndrome With and Without Glaucoma
NCT00001152
Visual Function and Ocular Pigmentation in Albinism
NCT00001153
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 42 |
| Phase 2 | 6 |
| Phase 3 | 4 |
Therapeutic Areas
What the Pipeline for National Eye Institute (NEI) Shows
According to the ClinicalTrials.gov registry, National Eye Institute (NEI) is linked to 214 US clinical trials across every stage of research activity. Of those, 161 studies are currently recruiting — about 75% of the sponsor's indexed portfolio — and 46 are already marked complete, representing roughly 21% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
The phase mix for National Eye Institute (NEI) reports 4 late-stage studies (Phase 3 and Phase 4 combined) and 48 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
The top therapeutic focus area indexed for National Eye Institute (NEI) is Age-Related Macular Degeneration with 7 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology — how this data is sourced, computed, and verified.