National Eye Institute (NEI)

221 total trials 18 currently recruiting 179 completed

National Eye Institute (NEI) sponsors 221 registered US clinical trials on ClinicalTrials.gov, 18 of them currently recruiting, and 179 completed. 11 of these trials are in Phase 3-4 (later-stage) and 86 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Age-related Macular Degeneration, with 8 trials.

Trial Pipeline

221 total, page 1 of 5

RECRUITING

National Ophthalmic Genotyping and Phenotyping Network (eyeGENE (Registered Trademark)), Stage 3 - Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases

NCT06491615

RECRUITING Phase 1

Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease

NCT04289571

RECRUITING

Stargardt-like Macular Dystrophy (STDG3) Secondary to Mutations in ELOVL4

NCT04591483

RECRUITING Phase 1

Oral Metformin for Treatment of ABCA4 Retinopathy

NCT04545736

RECRUITING Phase 1

Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated With Age-Related Macular Degeneration

NCT04339764

RECRUITING

Perception, Sensation, Cognition and Action in Humans

NCT03407066

RECRUITING

Clinical and Molecular Studies in Families With Inherited Eye Disease

NCT02771236

RECRUITING

Natural History, Pathogenesis, and Outcome of Ocular Disorders

NCT02821767

RECRUITING

Natural History of Spinocerebellar Ataxia Type 7 (SCA7)

NCT02741440

RECRUITING

Rod and Cone Mediated Function in Retinal Disease

NCT02617966

RECRUITING

Genetics of Inherited Eye Disease

NCT02471287

RECRUITING

Adaptive Optics Retinal Imaging

NCT02317328

RECRUITING

Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye Conditions

NCT02077894

RECRUITING

Pathogenesis and Genetics of Microphthalmia, Anophthalmia and Uveal Coloboma (MAC)

NCT01778543

RECRUITING

National Eye Institute Biorepository for Retinal Diseases

NCT01496625

RECRUITING

Cell Collection to Study Eye Diseases

NCT01432847

RECRUITING

Genotype-Phenotype Study of Patients With Plaquenil -Induced Retinal Toxicity, With Evaluation of the ABCA4 Gene

NCT01145196

RECRUITING

Screening for Research Participants

NCT00655096

ACTIVE NOT RECRUITING NA

Training to Modify Fixational Eye Movements for Optimizing Visual Performance in People With Central Vision Loss

NCT06670989

ACTIVE NOT RECRUITING

Retrospective Case Series of Trans-scleral Cryotherapy for Retinal Hemangioblastoma

NCT04458935

ACTIVE NOT RECRUITING

Dark Adaptation in Participants With Age-Related Macular Degeneration

NCT03225131

ACTIVE NOT RECRUITING

Natural History of Eye Diseases Related to ABCA4 Mutations

NCT01736293

ACTIVE NOT RECRUITING

Study of Dark Adaptation in Age-Related Macular Degeneration

NCT01352975

ACTIVE NOT RECRUITING

Age-Related Eye Disease Study (AREDS) Follow-Up

NCT00594672

ACTIVE NOT RECRUITING

Clinical and Genetic Studies of X-Linked Juvenile Retinoschisis

NCT00055029

COMPLETED

Potential Environmental Causes of Uveal Coloboma

NCT04833361

TERMINATED

Ocular Findings and Viral Persistence in Ocular Fluids in COVID-19 Survivors

NCT04665752

COMPLETED

Biomarkers in Ocular Inflammation and Uveitis

NCT04690829

COMPLETED

Retinitis Pigmentosa Clinical Measures and Repeatability Testing of Potential Outcome Measures

NCT03845218

COMPLETED

Generation of Induced Pluripotent Stem (iPS) Cell Lines From Skin Fibroblast Cells of Participants With Age-Related Macular Degeneration

NCT03372746

COMPLETED

Age-Related Eye Disease Study 2 (AREDS2) 10-year Follow-On

NCT03367767

COMPLETED Early Phase 1

Vitamin A Palmitate Supplementation in Patients With Reticular Pseudodrusen (RPD) and Delayed Dark Adaptation

NCT03478878

COMPLETED Early Phase 1

Vitamin A Palmitate Supplementation in People With Age-Related Macular Degeneration (and Without Reticular Pseudodrusen) and Delayed Dark Adaptation

NCT03478865

COMPLETED

AMD Ryan Initiative Study (ARIS)

NCT03092492

COMPLETED

Mothers Experiences With X-linked Retinoschisis Compared to Fathers Experiences

NCT03354403

COMPLETED Phase 2

Ustekinumab (STELARA) for the Treatment of Active Sight-Threatening Uveitis (STAR Study)

NCT02911116

COMPLETED

Natural History of Geographic Atrophy Associated With Age-Related Macular Degeneration

NCT02941263

COMPLETED Phase 1

A Phase I/II Trial for Intravitreous Treatment of Severe Ocular Von Hippel-Lindau Disease Using a Combination of the PDGF Antagonist E10030 and the VEGF Antagonist Ranibizumab

NCT02859441

COMPLETED Phase 2

Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration

NCT02564978

COMPLETED

Uveitis/Intraocular Inflammatory Disease Biobank (iBank)

NCT02656381

COMPLETED

The Focal Electro-Oculogram in Macular Disease

NCT02225119

TERMINATED Phase 1

Interferon Gamma-1b Administered Topically for Macular Edema/Intraretinal Schisis Cysts in Rod-Cone Dystrophy (RCD) and Enhanced S-Cone Syndrome (ESCS)

NCT02338973

COMPLETED

People s Expectations When Enrolling in a Phase I/II RS1 Ocular Gene Transfer Clinical Trial

NCT02317354

TERMINATED

Study of Retinal Findings in People With Signs and Symptoms of Alzheimer s Disease Enrolled in 09-M-0198

NCT02226835

COMPLETED Phase 1

Study of Oral Minocycline in Treating Bilateral Cystoid Macular Edema Associated With Retinitis Pigmentosa

NCT02140164

TERMINATED Phase 2

A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) Patients

NCT01972438

COMPLETED

Intestinal Bacteria and Ocular Inflammatory Disease

NCT01859299

COMPLETED

Study of the Effects of Supplements on Eye Disease in Participants From the Age-Related Eye Disease Study

NCT01915238

COMPLETED

Color Vision as a Measure for Inherited Retinal Diseases

NCT01878032

COMPLETED Phase 1

Nitisinone for Type 1B Oculocutaneous Albinism

NCT01838655

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What the Pipeline for National Eye Institute (NEI) Shows

According to the ClinicalTrials.gov registry, National Eye Institute (NEI) is linked to 221 US clinical trials across every stage of research activity. Of those, 18 studies are currently recruiting, about 8% of the sponsor's indexed portfolio, and 179 are already marked complete, representing roughly 81% of the total.

The phase mix for National Eye Institute (NEI) reports 11 late-stage studies (Phase 3 and Phase 4 combined) and 86 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Eye Institute (NEI) is Age-related Macular Degeneration with 8 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.