National Eye Institute (NEI)

214 total trials 161 currently recruiting 46 completed

Trial Pipeline

RECRUITING

National Ophthalmic Genotyping and Phenotyping Network (eyeGENE (Registered Trademark)), Stage 3 - Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases

NCT06491615

RECRUITING Phase 1

Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease

NCT04289571

RECRUITING

Stargardt-like Macular Dystrophy (STDG3) Secondary to Mutations in ELOVL4

NCT04591483

RECRUITING Phase 1

Oral Metformin for Treatment of ABCA4 Retinopathy

NCT04545736

RECRUITING Phase 1

Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated With Age-Related Macular Degeneration

NCT04339764

RECRUITING

Perception, Sensation, Cognition and Action in Humans

NCT03407066

RECRUITING

Clinical and Molecular Studies in Families With Inherited Eye Disease

NCT02771236

RECRUITING

Natural History, Pathogenesis, and Outcome of Ocular Disorders

NCT02821767

RECRUITING

Natural History of Spinocerebellar Ataxia Type 7 (SCA7)

NCT02741440

RECRUITING

Rod and Cone Mediated Function in Retinal Disease

NCT02617966

RECRUITING

Genetics of Inherited Eye Disease

NCT02471287

RECRUITING

Adaptive Optics Retinal Imaging

NCT02317328

RECRUITING

Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye Conditions

NCT02077894

RECRUITING

Pathogenesis and Genetics of Microphthalmia, Anophthalmia and Uveal Coloboma (MAC)

NCT01778543

RECRUITING

National Eye Institute Biorepository for Retinal Diseases

NCT01496625

RECRUITING

Cell Collection to Study Eye Diseases

NCT01432847

RECRUITING

Genotype-Phenotype Study of Patients With Plaquenil -Induced Retinal Toxicity, With Evaluation of the ABCA4 Gene

NCT01145196

RECRUITING

Screening for Research Participants

NCT00655096

ACTIVE NOT RECRUITING NA

Training to Modify Fixational Eye Movements for Optimizing Visual Performance in People With Central Vision Loss

NCT06670989

ACTIVE NOT RECRUITING

Retrospective Case Series of Trans-scleral Cryotherapy for Retinal Hemangioblastoma

NCT04458935

ACTIVE NOT RECRUITING

Dark Adaptation in Participants With Age-Related Macular Degeneration

NCT03225131

ACTIVE NOT RECRUITING

Natural History of Eye Diseases Related to ABCA4 Mutations

NCT01736293

ACTIVE NOT RECRUITING

Study of Dark Adaptation in Age-Related Macular Degeneration

NCT01352975

ACTIVE NOT RECRUITING

Age-Related Eye Disease Study (AREDS) Follow-Up

NCT00594672

ACTIVE NOT RECRUITING

Clinical and Genetic Studies of X-Linked Juvenile Retinoschisis

NCT00055029

COMPLETED

Potential Environmental Causes of Uveal Coloboma

NCT04833361

COMPLETED

Mothers Experiences With X-linked Retinoschisis Compared to Fathers Experiences

NCT03354403

COMPLETED Phase 2

Ustekinumab (STELARA) for the Treatment of Active Sight-Threatening Uveitis (STAR Study)

NCT02911116

COMPLETED

The Focal Electro-Oculogram in Macular Disease

NCT02225119

COMPLETED

Intestinal Bacteria and Ocular Inflammatory Disease

NCT01859299

COMPLETED

Study of the Effects of Supplements on Eye Disease in Participants From the Age-Related Eye Disease Study

NCT01915238

COMPLETED Phase 1

Optiquel® as Corticosteroid-sparing Therapy for Chronic Noninfectious Uveitis

NCT01195948

COMPLETED Phase 1

Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti

NCT00876434

COMPLETED Phase 1

Pilot Study of the Evaluation of Subconjunctival Sirolimus in the Treatment of Bilateral GA Associated With AMD

NCT00766649

COMPLETED

Validation of Computerized Vision-Targeted Quality-of-Life Questionnaires

NCT00678860

COMPLETED

High Speed Indocyanine Green Angiography Findings in Ranibizumab Treatment for Wet Age-related Macular Degeneration

NCT00656903

COMPLETED

Genetics and Markers of Degenerative and Inflammatory Eye Diseases

NCT00647439

COMPLETED

Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure

NCT00471731

COMPLETED Phase 1

Injected Ranibizumab to Treat Macular Telangiectasia With New Blood Vessel Formation

NCT00457067

COMPLETED

Clinical and Genetic Studies in Families With Myopia and Related Diseases

NCT00272376

COMPLETED

Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia

NCT00265590

COMPLETED

Molecular Genetics of Retinal Degenerations

NCT00231010

COMPLETED Phase 2

Triamcinolone Acetonide Injections to Treat Diabetic Macular Edema

NCT00231023

COMPLETED Phase 2

Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis

NCT00130637

COMPLETED

Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study

NCT00116090

COMPLETED Phase 3

Steroid Injections vs. Standard Treatment for Macular Edema Due to Retinal Blood Vessel Blockage

NCT00106132

COMPLETED Phase 1

Intravitreal v. Sub-tenon Injections of Triamcinolone Acetonide for Macular Edema in Retinal Disorders

NCT00101764

COMPLETED Phase 3

Triamcinolone Acetonide Plus Laser Therapy to Treat Age-Related Macular Degeneration

NCT00100009

COMPLETED

Immune Indicators of Uveitis

NCT00089739

COMPLETED

Efficacy of Elevated CD4 Counts on CMV Retinitis

NCT00091884

COMPLETED Phase 2

Evaluation and Treatment of Eye Complications of Vaccinia Vaccination

NCT00081835

COMPLETED

Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases

NCT00076271

COMPLETED

Studies in Families With Corneal Dystrophy or Other Inherited Corneal Diseases

NCT00357435

COMPLETED Phase 1

Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa

NCT00065455

COMPLETED

Immune Responses to Antigens in Non-infectious Eye Inflammatory Diseases

NCT00357071

COMPLETED

Clinical and Genetic Studies of Families With Congenital or Hereditary Cataracts

NCT00056771

COMPLETED Phase 1

EYE001 to Treat Retinal Tumors in Patients With Von Hippel-Lindau Syndrome

NCT00056199

COMPLETED

Biological Markers in Retinal Vasculitis

NCT00050492

COMPLETED Phase 1

Identification and Treatment of Feeder Vessels in Macular Degeneration

NCT00018070

COMPLETED

Genetic Study of Age-Related Macular Degeneration

NCT00357578

COMPLETED Phase 2

Eye Muscle Surgery to Treat Congenital Nystagmus

NCT00001866

COMPLETED Phase 3

Amblyopia (Lazy Eye) Treatment Study

NCT00001864

COMPLETED

Screening for Studies on Nystagmus and Strabismus

NCT00001861

COMPLETED Phase 2

Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops

NCT00001731

COMPLETED

Test of QLS Device to Detect Early Cataracts

NCT00001617

COMPLETED

Cataract Surgery to Obtain Human Lens Material for the Study of Nuclear Cataracts

NCT00001613

COMPLETED Phase 3

The Effects of Light Reduction on Retinopathy of Prematurity (Light-ROP)

NCT00000156

COMPLETED NA

Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) - Outcome Study of Cryotherapy for Retinopathy of Prematurity

NCT00000133

COMPLETED

Visual Stimulus and Eye Movement

NCT00001172

COMPLETED

Pigment Dispersion Syndrome With and Without Glaucoma

NCT00001152

COMPLETED

Visual Function and Ocular Pigmentation in Albinism

NCT00001153

What the Pipeline for National Eye Institute (NEI) Shows

According to the ClinicalTrials.gov registry, National Eye Institute (NEI) is linked to 214 US clinical trials across every stage of research activity. Of those, 161 studies are currently recruiting — about 75% of the sponsor's indexed portfolio — and 46 are already marked complete, representing roughly 21% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

The phase mix for National Eye Institute (NEI) reports 4 late-stage studies (Phase 3 and Phase 4 combined) and 48 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

The top therapeutic focus area indexed for National Eye Institute (NEI) is Age-Related Macular Degeneration with 7 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial