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NCT02224339 · ClinicalTrials.gov registry record
New Technologies to Determine Carotid Plaque Vulnerability
A clinical trial of Atherosclerosis and Carotid Artery Plaque, sponsored by Mayo Clinic.
- Completed
- Registry status
- 216
- Enrollment target
- 1
- Study location
NCT02224339: Completed study of Atherosclerosis and Carotid Artery Plaque, sponsored by Mayo Clinic.
NCT02224339 is a study of Atherosclerosis and Carotid Artery Plaque that has completed, run by Mayo Clinic. The registered enrollment target is 216 participants, below the 1,063-participant average among 69 other Atherosclerosis trials with a reported enrollment target (80% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02224339, a study of Atherosclerosis and Carotid Artery Plaque, has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- 216 participants
- Enrollment target
- 1
- Study location
Study Summary
Hypothesis: Identification of vulnerable atherosclerotic plaques (with or without neovascularization) using carotid CEUS is an independent predictor of MACE (over clinical risk factors, stress echo wall motion results, and carotid ultrasound two-dimensional speckle tracking strain indices). Primary Aims: 1. Evaluate the diagnostic role of carotid CEUS and two-dimensional speckle tracking strain imaging for detection of carotid plaque: * To determine the feasibility and safety of Carotid CEUS and Two-dimensional speckle tracking strain imaging SE . * To determine if carotid CEUS and two-dimensional speckle tracking strain imaging findings are associated with coronary angiographic results in those patients undergoing clinically indicated cardiac catheterization. * To determine the diagnostic accuracy of CEUS in identifying a vulnerable atherosclerotic plaque and neovascularization compared to carotid MRI, in a subset of patients. 2. Evaluate the prognostic role of carotid CEUS and two-dimensional speckle tracking strain imaging for prediction of MACE: * To determine if plaque identification (with or without neovascularization) on Carotid CEUS SE can improve the overall prediction of MACE over stress echo results alone * To determine if Carotid ultrasound two-dimensional speckle tracking strain indices can improve the overall prediction of MACE over stress echo results alone. * To determine if the detection of plaque neovascularization by Carotid CEUS is an independent predictor of MACE (over clinical risk factors, stress echo wall motion results, and carotid ultrasound two-dimensional speckle tracking strain indices).
Primary Outcome
The primary endpoint is the cumulative incidence of cardiac death during the 24 months followup from the SE and carotid imaging (strain and CEUS).
Conditions Studied
Study Locations (1)
Minnesota
- Mayo Clinic - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 216 participants |
| Start Date | 2014-09 |
| Est. Completion | 2019-01 |
What the finished NCT02224339 record still lists
NCT02224339 is an observational study that tracks outcomes without assigning an intervention. The registered 216 participants enrollment target is mid-sized for trials with a published cap, below the 1,063-participant average among 69 other Atherosclerosis trials with a reported enrollment target (80% lower).
The record links to 2 conditions, with Atherosclerosis appearing as the primary indexed condition, and to 0 interventions.
NCT02224339 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT02224339 about?
NCT02224339 is a clinical study titled "New Technologies to Determine Carotid Plaque Vulnerability". Hypothesis: Identification of vulnerable atherosclerotic plaques (with or without neovascularization) using carotid CEUS is an independent predictor of MACE (over clinical risk factors, stress echo wall motion results, and carotid ultrasound two-dimensional speckle tracking strain indices). Primary...
What is the current status of trial NCT02224339?
This trial is currently completed. The enrollment target is 216 participants. The study started on 2014-09. Estimated completion is 2019-01.
What conditions does trial NCT02224339 study?
This clinical trial studies the following conditions: Atherosclerosis, Carotid Artery Plaque.
Who is sponsoring clinical trial NCT02224339?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02224339 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Atherosclerosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02224339's enrollment target sits among peer trials
216 35th of 69 higher than 35 of 69 other Atherosclerosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Atherosclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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