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NCT05470218 · ClinicalTrials.gov registry record · NA
Leucine, MTOR and Athero
A NA study of Atherosclerosis, sponsored by University of Missouri-Columbia.
- Active
- Registry status
- NA
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT05470218 is a NA study of Atherosclerosis that is active but no longer recruiting, run by University of Missouri-Columbia. The registered enrollment target is 10 participants, below the 1,066-participant average among 69 other Atherosclerosis trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05470218, a NA study of Atherosclerosis, is active but no longer recruiting, sponsored by University of Missouri-Columbia.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
High protein low carbohydrate diets have become popular in recent years to help facilitate weight loss. It is controversial if these diets are associated with an increased risk of cardiovascular disease. Recent work in mice has implicated monocytes/macrophages and mTOR signaling as the culprit cell type driving the increased cardiovascular risk with high protein diets. We aim to build on this preclinical research by evaluating the effects of liquid meals with different protein and leucine (a potent mTOR activator) contents on circulating human monocytes and platelets. Study participants will be given either a low protein liquid meal, a high protein liquid meal, or a low protein liquid meal with additional leucine. Blood will be collected from study participants just just prior to and for several hours after ingestion of the meals. Activation of amino acid-dependent signaling pathways (particularly mTOR) and downstream sequelae will be evaluated in the isolated monocytes and platelets.
Conditions Studied
Interventions
- OTHER Meal
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2022-07-12 |
| Est. Completion | 2026-08-14 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05470218
The ClinicalTrials.gov registry entry for NCT05470218 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 10 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,066-participant average among 69 other Atherosclerosis trials with a reported enrollment target (99% lower). The listed sponsor is University of Missouri-Columbia, which has 291 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Atherosclerosis appearing as the primary indexed condition, and to 1 intervention - of which Meal is the first listed.
NCT05470218 reports 1 study location spanning 1 distinct geographic area - top geographies include Missouri.
Frequently Asked Questions
What is clinical trial NCT05470218 about?
NCT05470218 is a clinical study titled "Leucine, MTOR and Athero". High protein low carbohydrate diets have become popular in recent years to help facilitate weight loss. It is controversial if these diets are associated with an increased risk of cardiovascular disease. Recent work in mice has implicated monocytes/macrophages and mTOR signaling as the culprit cell ...
What is the current status of trial NCT05470218?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 10 participants. The study started on 2022-07-12. Estimated completion is 2026-08-14.
What conditions does trial NCT05470218 study?
This clinical trial studies the following conditions: Atherosclerosis.
What interventions are being tested in trial NCT05470218?
The interventions under investigation include: Meal (OTHER).
Who is sponsoring clinical trial NCT05470218?
This trial is sponsored by University of Missouri-Columbia, which has 291 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05470218 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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