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NCT02915198 · ClinicalTrials.gov registry record · Phase 4
Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes
A Phase 4 study of Atherosclerosis and Prediabetic State, sponsored by VA Office of Research and Development.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 7,410
- Enrollment target
- 20
- Study locations
NCT02915198: Recruiting Phase 4 study of Atherosclerosis and Prediabetic State, sponsored by VA Office of Research and Development.
NCT02915198 is a Phase 4 study of Atherosclerosis and Prediabetic State that is actively recruiting participants, run by VA Office of Research and Development. The registered enrollment target is 7,410 participants, above the 958-participant average among 69 other Atherosclerosis trials with a reported enrollment target (673% higher). The trial reports 20 study locations across 12 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02915198, a Phase 4 study of Atherosclerosis and Prediabetic State, is actively recruiting participants, sponsored by VA Office of Research and Development.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 7,410 participants
- Enrollment target
- 20
- Study locations
Study Summary
This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in Veterans who have pre-diabetes and heart or blood vessel problems.
Primary Outcome
The primary outcome measure is the time to first occurrence of death, non-fatal myocardial infarction or stroke, hospitalization for unstable angina with objective evidence of acute myocardial ischemia, or coronary revascularization driven by acute or progressive symptoms.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Metformin XR
Study Locations (20)
California
- VA Loma Linda Healthcare System, Loma Linda, CA - Loma Linda
- VA Long Beach Healthcare System, Long Beach, CA - Long Beach
- VA Palo Alto Health Care System, Palo Alto, CA - Palo Alto
- VA San Diego Healthcare System, San Diego, CA - San Diego
- VA Greater Los Angeles Healthcare System, West Los Angeles, CA - West Los Angeles
Florida
- Bay Pines VA Healthcare System, Pay Pines, FL - Bay Pines
- North Florida/South Georgia Veterans Health System, Gainesville, FL - Gainesville
- Miami VA Healthcare System, Miami, FL - Miami
Arizona
- Phoenix VA Health Care System, Phoenix, AZ - Phoenix
- Southern Arizona VA Health Care System, Tucson, AZ - Tucson
Illinois
- Jesse Brown VA Medical Center, Chicago, IL - Chicago
- Edward Hines Jr. VA Hospital, Hines, IL - Hines
Arkansas
- Central Arkansas VHS John L. McClellan Memorial Veterans Hospital, Little Rock, AR - Little Rock
Colorado
- Rocky Mountain Regional VA Medical Center, Aurora, CO - Aurora
Connecticut
- VA Connecticut Healthcare System West Haven Campus, West Haven, CT - West Haven
Georgia
- Atlanta VA Medical and Rehab Center, Decatur, GA - Decatur
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7,410 participants |
| Start Date | 2023-04-03 |
| Est. Completion | 2029-09-28 |
| Phase | Phase 4 |
What NCT02915198 shows while recruiting
NCT02915198 is an interventional study that assigns participants to a tested intervention. Its 7,410 participants enrollment target places it among the larger protocols in the corpus, above the 958-participant average among 69 other Atherosclerosis trials with a reported enrollment target (673% higher).
The record links to 3 conditions, with Atherosclerosis appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT02915198 names 20 study sites across 12 states, led by California, Florida, Arizona.
Frequently Asked Questions
What is clinical trial NCT02915198 about?
NCT02915198 is a clinical study titled "Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes". This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in Veterans who have pre-diabetes and heart or blood vessel problems.
What is the current status of trial NCT02915198?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 7,410 participants. The study started on 2023-04-03. Estimated completion is 2029-09-28.
What conditions does trial NCT02915198 study?
This clinical trial studies the following conditions: Atherosclerosis, Prediabetic State, Metformin.
What interventions are being tested in trial NCT02915198?
The interventions under investigation include: Placebo (DRUG), Metformin XR (DRUG).
Who is sponsoring clinical trial NCT02915198?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02915198 being conducted?
This trial has 20 study locations across Arizona, Arkansas, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Atherosclerosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02915198's enrollment target sits among peer trials
7,410 3rd of 69 higher than 67 of 69 other Atherosclerosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Atherosclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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