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NCT00880178 · ClinicalTrials.gov registry record
Plaque Inflammation and Dysfunctional HDL in AIM-HIGH
A clinical trial of Cardiovascular Diseases and Heart Diseases, sponsored by University of Washington.
- Completed
- Registry status
- 324
- Enrollment target
- 20
- Study locations
NCT00880178: Completed study of Cardiovascular Diseases and Heart Diseases, sponsored by University of Washington.
NCT00880178 is a study of Cardiovascular Diseases and Heart Diseases that has completed, run by University of Washington. The registered enrollment target is 324 participants, below the 26,973-participant average among 300 other Cardiovascular Diseases trials with a reported enrollment target (99% lower). The trial reports 20 study locations across 11 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00880178, a study of Cardiovascular Diseases and Heart Diseases, has completed, sponsored by University of Washington.
- COMPLETED
- Registry status
- 324 participants
- Enrollment target
- 20
- Study locations
Study Summary
Coronary heart disease (CHD) is a serious health concern that affects millions of people in the United States. It is usually caused by atherosclerosis-a condition that occurs when fatty material and plaque build up on the walls of the arteries that supply blood and oxygen to the heart, causing the arteries to narrow. As the arteries narrow, blood flow to the heart can slow down or stop, which can cause chest pain, shortness of breath, heart attack, or heart failure. Another component of CHD events involves inflammatory changes that result in structural breakdown of atherosclerotic plaques. Adding niacin to statin medications may be an effective way to block inflammation in the atherosclerotic plaques. This study will examine magnetic resonance imaging (MRI) images and blood samples of participants in the AIM-HIGH study who are taking niacin plus statins or statins alone to determine the effect of these medications on inflammation in atherosclerotic plaques.
Conditions Studied
Interventions
- DRUG Simvastatin
- DRUG Simvastatin and Extended-Release niacin
Study Locations (20)
North Carolina
- Duke University - Durham
- Wake Forest University, Geriatrics - Greensboro
- Wake Forest University, Cardiology - Winston-Salem
- Wake Forest University, Endocrinology - Winston-Salem
Minnesota
- University of Minnesota - Minneapolis
- HealthPartners Riverside Clinic - Minneapolis
- Mayo Clinic - Rochester
Pennsylvania
- Philadelphia VA Medical Center - Philadelphia
- Pennsylvania Cardiology Associates - Philadelphia
- Cardiology Consultants of Philadelphia - Philadelphia
Texas
- Baylor College of Medicine - Houston
- Kelsey Research Foundation - Houston
- Methodist Hospital - Houston
Alabama
- Cardiovascular Associates - Birmingham
Arizona
- Cardiovascular Consultants - Phoenix
California
- Long Beach VA Medical Center - Long Beach
Delaware
- Christiana Care Health Services - Newark
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 324 participants |
| Start Date | 2008-05 |
| Est. Completion | 2011-09 |
What the finished NCT00880178 record still lists
NCT00880178 is an observational study that tracks outcomes without assigning an intervention. The registered 324 participants enrollment target is mid-sized for trials with a published cap, below the 26,973-participant average among 300 other Cardiovascular Diseases trials with a reported enrollment target (99% lower).
The record links to 5 conditions, with Cardiovascular Diseases appearing as the primary indexed condition, and to 2 interventions - of which Simvastatin is the first listed.
NCT00880178 names 20 study sites across 11 states, led by North Carolina, Minnesota, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT00880178 about?
NCT00880178 is a clinical study titled "Plaque Inflammation and Dysfunctional HDL in AIM-HIGH". Coronary heart disease (CHD) is a serious health concern that affects millions of people in the United States. It is usually caused by atherosclerosis-a condition that occurs when fatty material and plaque build up on the walls of the arteries that supply blood and oxygen to the heart, causing the a...
What is the current status of trial NCT00880178?
This trial is currently completed. The enrollment target is 324 participants. The study started on 2008-05. Estimated completion is 2011-09.
What conditions does trial NCT00880178 study?
This clinical trial studies the following conditions: Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Myocardial Infarction, Coronary Disease.
What interventions are being tested in trial NCT00880178?
The interventions under investigation include: Simvastatin (DRUG), Simvastatin and Extended-Release niacin (DRUG).
Who is sponsoring clinical trial NCT00880178?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00880178 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Delaware, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00880178's enrollment target sits among peer trials
324 119th of 300 higher than 182 of 300 other Cardiovascular Diseases trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cardiovascular Diseases trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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